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UniProtKB - F6YCR7 (RHX13_MOUSE)
Protein
Homeobox protein Rhox13
Gene
Rhox13
Organism
Mus musculus (Mouse)
Status
Functioni
Probable transcription factor.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 148 – 207 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- cellular response to retinoic acid Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Rhox13CuratedAlternative name(s): Reproductive homeobox protein 13Imported |
Gene namesi | Name:Rhox13Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920864, Rhox13 |
VEuPathDBi | HostDB:ENSMUSG00000050197 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation1 Publication
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000435030 | 1 – 232 | Homeobox protein Rhox13Add BLAST | 232 |
Proteomic databases
PaxDbi | F6YCR7 |
PRIDEi | F6YCR7 |
ProteomicsDBi | 253282 |
Expressioni
Developmental stagei
In adult testis, expressed in differentiating spermatagonia and preleptotene spermatocytes, but not during other stages of spermatogenesis (at protein level). Detected in testis from 13.5 days post coitum (dpc) onwards. Detected in ovary from 13.5 dpc, but levels gradually decline and are undetectable by 3 days post partum (dpp).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000050197, Expressed in testis and 33 other tissues |
Genevisiblei | F6YCR7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000117271 |
Miscellaneous databases
RNActi | F6YCR7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 114 | DisorderedSequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 70 – 104 | Acidic residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the paired-like homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000163385 |
HOGENOMi | CLU_1194575_0_0_1 |
InParanoidi | F6YCR7 |
OMAi | IRQMCKE |
OrthoDBi | 1270742at2759 |
PhylomeDBi | F6YCR7 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F6YCR7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHGVPFDHN YYIVECKEET NAEAQAGAMA ATSTEEAPGA VEVAQAAVAS
60 70 80 90 100
SHDSGGAIGC ATVKESESDS ESESDSESES DSSDSSDESD DDSSTSDEDT
110 120 130 140 150
SDPEEAAAPS VAAVAAAAAP PTVPAAAAIQ IPGPYRYRPP RRHVRRRRRG
160 170 180 190 200
PPFHFAQWQV EEMESLFEET QYPDLLTRGE LARTLNVPEV KVKVWFTNRR
210 220 230
AKQRKIERRE MLRNIPPGAE DFIFITDFEE PS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | Y → D in BAC25170 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL512346 Genomic DNA No translation available. AK007253 mRNA Translation: BAC25170.1 |
CCDSi | CCDS57754.1 |
RefSeqi | NP_001171931.1, NM_001185002.1 |
Genome annotation databases
Ensembli | ENSMUST00000152730; ENSMUSP00000117271; ENSMUSG00000050197 |
GeneIDi | 73614 |
KEGGi | mmu:73614 |
UCSCi | uc009szo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL512346 Genomic DNA No translation available. AK007253 mRNA Translation: BAC25170.1 |
CCDSi | CCDS57754.1 |
RefSeqi | NP_001171931.1, NM_001185002.1 |
3D structure databases
SMRi | F6YCR7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000117271 |
Proteomic databases
PaxDbi | F6YCR7 |
PRIDEi | F6YCR7 |
ProteomicsDBi | 253282 |
Genome annotation databases
Ensembli | ENSMUST00000152730; ENSMUSP00000117271; ENSMUSG00000050197 |
GeneIDi | 73614 |
KEGGi | mmu:73614 |
UCSCi | uc009szo.2, mouse |
Organism-specific databases
CTDi | 73614 |
MGIi | MGI:1920864, Rhox13 |
VEuPathDBi | HostDB:ENSMUSG00000050197 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000163385 |
HOGENOMi | CLU_1194575_0_0_1 |
InParanoidi | F6YCR7 |
OMAi | IRQMCKE |
OrthoDBi | 1270742at2759 |
PhylomeDBi | F6YCR7 |
Miscellaneous databases
BioGRID-ORCSi | 73614, 2 hits in 63 CRISPR screens |
PROi | PR:F6YCR7 |
RNActi | F6YCR7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050197, Expressed in testis and 33 other tissues |
Genevisiblei | F6YCR7, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHX13_MOUSE | |
Accessioni | F6YCR7Primary (citable) accession number: F6YCR7 Secondary accession number(s): Q8C1Q7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 9, 2015 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families