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UniProtKB - F6YB97 (F6YB97_HORSE)

Entry version 53 (07 Oct 2020)
Sequence version 3 (11 Dec 2019)
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Protein

zf-C2H2_12 domain-containing protein

Gene

LOC100062625

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
zf-C2H2_12 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100062625Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6YB97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000021592, Expressed in endometrium and 21 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 488zf-C2H2_12InterPro annotationAdd BLAST62

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162266

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_310345_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6YB97

Identification of Orthologs from Complete Genome Data

More...OMAi		HHCAKVL

Database of Orthologous Groups

More...OrthoDBi		788135at2759

TreeFam database of animal gene trees

More...TreeFami		TF352524

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.1460.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR042224, GTF2IRD2
IPR012337, RNaseH-like_sf
IPR040647, SPIN-DOC_Znf-C2H2

The PANTHER Classification System

More...PANTHERi		PTHR47831, PTHR47831, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02946, GTF2I, 2 hits
PF18658, zf-C2H2_12, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117773, SSF117773, 2 hits
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51139, GTF2I, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6YB97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVAVSTLS VENESTESRM VVTFLVSALE SMCKELAKSK AEVACIAVYE 
        60         70         80         90        100
TDVFVVGTDR GRAFVNARAD LQKDFAKYCI AAGLPEVKPP RPANGMPMES 
       110        120        130        140        150
GETEILRKAV EDYFCLCYGK ALGTTVMVPV PYEKMQRDQA AVRVQGLPEG 
       160        170        180        190        200
VTFQHPENYD LATLKWILEK KAGISFVINR PFLGPANQLG GPVVVTDAER 
       210        220        230        240        250
SMTSPSESCG SINVKTEPME DSGISVKAAA VSVKKESDDP NYYRYNMQES 
       260        270        280        290        300
HHSSGSSEVI EMELPMEDST QLVPPETSED PEAEVKTEGN IISSRLTDSA 
       310        320        330        340        350
AGVEDLNIVQ VPVPDNEKER LPSIEKIKQL REQVNDLFSR KFGEAIGVDF 
       360        370        380        390        400
PVKVPYRKIA FNPGCVVIDG MPPGVVFKAP GYLEISSMRR ILDAAEFIKF 
       410        420        430        440        450
TVLRPLPGLE LSNVGKRKID QEGRVFQEKW ERAYFFVDVQ NIPTCLICKQ 
       460        470        480        490        500
SMSVSKEYNL RRHYQTNHSK HYDQYTEKMR DEKLHELKKG LRKYLLGSSE 
       510        520        530        540        550
IVCPEQHQGF ANVSPAEAAA VQPVEDVAGH LWEKLREKIK SFVAYSVAID 
       560        570        580        590        600
EITDINNTTQ LAIFIRGVDE NFDVSEELLD TVPMTGTKSG NEIFLRVEKS 
       610        620        630        640        650
LKKFNIDWSK LVSVASTGTP AMVDANDGLV TKLKSKVAMV GKGSDLKSMC 
       660        670        680        690        700
CILHPESLCA QKLKMDHVMS VVVSSVNWIC SRGVNHSEFT TLLYELDSQY 
       710        720        730        740        750
GSLLYCTEIK WLSRGLVLKR FFESLEEIDS FMSSRGKPLP QLSSQDWIKD 
       760        770        780        790        800
LAFLVDMTTH LNTLNISLQG HSQIVTQMYD LIRAFLAKLC LWETHLARNN 
       810        820        830        840        850
LAHFPTLKSV SRNESDGLNY IPKIVELKTE FQKRLSEFKL YESELTLFSS 
       860        870        880        890        900
PFSMKIESVP EALQMEVIDL QCNTVLKTKY DKVGIPEFYR YLWSSYPRYK 
       910        920        930        940 
THCAKILSMF GSTYICEQLF SIMKLSKTKF CSQLKDSQWD SVLHITA
Length:947
Mass (Da):106,506
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED033BAB1753EF16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2KSC2A0A3Q2KSC2_HORSE
Uncharacterized protein
LOC100062625
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_001494185.1, XM_001494135.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000023208; ENSECAP00000019210; ENSECAG00000021592

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100062625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecb:100062625

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_001494185.1, XM_001494135.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6YB97

Genome annotation databases

EnsembliENSECAT00000023208; ENSECAP00000019210; ENSECAG00000021592
GeneIDi100062625
KEGGiecb:100062625

Phylogenomic databases

GeneTreeiENSGT00940000162266
HOGENOMiCLU_310345_0_0_1
InParanoidiF6YB97
OMAiHHCAKVL
OrthoDBi788135at2759
TreeFamiTF352524

Gene expression databases

BgeeiENSECAG00000021592, Expressed in endometrium and 21 other tissues

Family and domain databases

Gene3Di3.90.1460.10, 2 hits
InterProiView protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR042224, GTF2IRD2
IPR012337, RNaseH-like_sf
IPR040647, SPIN-DOC_Znf-C2H2
PANTHERiPTHR47831, PTHR47831, 1 hit
PfamiView protein in Pfam
PF02946, GTF2I, 2 hits
PF18658, zf-C2H2_12, 1 hit
SUPFAMiSSF117773, SSF117773, 2 hits
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS51139, GTF2I, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6YB97_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6YB97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 53 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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