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Protein

Mast/stem cell growth factor receptor

Gene

KIT

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi564MagnesiumUniRule annotation1
Binding sitei619ATPUniRule annotation1
Binding sitei792ATPUniRule annotation1
Metal bindingi793MagnesiumUniRule annotation1
Metal bindingi806MagnesiumUniRule annotation1
Sitei932Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi592 – 599ATPUniRule annotation8
Nucleotide bindingi667 – 673ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mast/stem cell growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:KITImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei521 – 544HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501521908926 – 972Mast/stem cell growth factor receptorUniRule annotationAdd BLAST947

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF6YAJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 308Ig-likeInterPro annotationAdd BLAST97
Domaini585 – 933Protein kinaseInterPro annotationAdd BLAST349

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
OMAiPTFKQIV
OrthoDBiEOG091G01TL
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR027263 SCGF_receptor
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF500951 SCGF_recepter, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

F6YAJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PEEASPPFID PAKSELIVSV
60 70 80 90 100
GDEIRLFCND PGFVKWTFEV LDQMNENKQK EWIMQKAEAT NTGKYTCTNK
110 120 130 140 150
HGLSSSIYVF VRDPDKLFLV DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG
160 170 180 190 200
CQGKPIPKDL RFVPDPKAGI TIKNVKRAYH RLCLHCSADR KGQSKLSEKF
210 220 230 240 250
ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS SVYSSWKKEN
260 270 280 290 300
SPTKLQEKYN SWHQGDFNYE RQATLTISSV RVNDSGVFMC YASNTFGSAN
310 320 330 340 350
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PRPEHQQWIY
360 370 380 390 400
MNRTFTDKWE DYPKSENESN IRYVSELHLT RLKDTEGGTY TFLVSNSDVS
410 420 430 440 450
ASIAFTVYVN TKPEILTYDR LMNGMLQCVA AGFPEPTIDW YFCPGTEQRC
460 470 480 490 500
SAPVLPVDVQ IQNTSGPPFG KLVVQSSIDS SAFKHNGTVE CKAYNDVGKT
510 520 530 540 550
SAYFNFAFKE QIQPHTLFTP LLIGFVVVAG MMCIIVMILT YKYLQKPMYE
560 570 580 590 600
VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV
610 620 630 640 650
EATAYGLIKS DTAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV
660 670 680 690 700
NLLGACTIGG PTLVITEYCC YGDLLNFLRR KRDSFICSKQ EDHAEAALYK
710 720 730 740 750
NLLHSKESSC SDSTNEYMDM KPGVSYVVPT KAEKRRSARV GSYIERDVTP
760 770 780 790 800
AIMEDDELAL DLEDLLSFSY QVAKGMAFLA SKNCIHRDLA ARNILLTHGR
810 820 830 840 850
ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC VYTFESDVWS
860 870 880 890 900
YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMLSPEH APAEMYDIMK
910 920 930 940 950
TCWDADPLKR PTFKQIVQLI EKQISESTNH IYSNLTNCSP SQQKPVVDHS
960 970
VRINSVGSTA SSSQPLLVRD DV
Length:972
Mass (Da):109,664
Last modified:June 20, 2018 - v2
Checksum:i9B0539366BA964BD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q76II0KIT_CALJA
Mast/stem cell growth factor recept...
KIT
972Annotation score:
A0A2R8M5Y1A0A2R8M5Y1_CALJA
Mast/stem cell growth factor recept...
KIT
1,002Annotation score:

Genome annotation databases

EnsembliENSCJAT00000036036; ENSCJAP00000034112; ENSCJAG00000018396

Similar proteinsi

Entry informationi

Entry nameiF6YAJ6_CALJA
AccessioniPrimary (citable) accession number: F6YAJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: July 18, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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