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Protein

V-type proton ATPase subunit a

Gene

atp6v0a4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-XTR-1222556 ROS, RNS production in phagocytes
R-XTR-77387 Insulin receptor recycling
R-XTR-917977 Transferrin endocytosis and recycling
R-XTR-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:atp6v0a4Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493197 atp6v0a4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei304 – 333HelicalUniRule annotationAdd BLAST30
Transmembranei353 – 372HelicalUniRule annotationAdd BLAST20
Transmembranei451 – 472HelicalUniRule annotationAdd BLAST22
Transmembranei478 – 502HelicalUniRule annotationAdd BLAST25
Transmembranei547 – 568HelicalUniRule annotationAdd BLAST22
Transmembranei674 – 696HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSXETG00000011571 Expressed in 6 organ(s), highest expression level in mesonephros
ExpressionAtlasiF6Y932 baseline

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004941

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629 PTHR11629, 2 hits
PfamiView protein in Pfam
PF01496 V_ATPase_I, 3 hits
PIRSFiPIRSF001293 ATP6V0A1, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F6Y932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLFRSEEM SLTQLILQVE AGYCCIAELG ELGLVQFRDL NASVNSFQRR
60 70 80 90 100
FVNEVRRCEN MERILPLIES LAQQVQGVLM LVNQAPVXPY PDPTIPYRAP
110 120 130 140 150
HNNILGQHRA GLEPPRRGWL RSVSVLYMGP CVLQAEANLP DDFFSEDTSS
160 170 180 190 200
LLELRTIPSA AAAGKLGFTA GVINRERMAT FERLLWRVCR GNIYLKYTEL
210 220 230 240 250
DTALEDPVTK EEVKKNVFII FYQGDQLKLK IKKICDGSVT GILCQMKKIS
260 270 280 290 300
NSKXTIAPIL TNISSKLDPP TFNRTNKFTS GFQNIVNAYG VGSYREMNPT
310 320 330 340 350
PYTIITFPFL FAVMFGDCGH GSVMLGFALW MVLNEKQLLA SKTDNEIWNT
360 370 380 390 400
FFGGRYLILL MSIFSIYTGF IYNDCFSKSF DIFGSSWRVR PMFINKTWND
410 420 430 440 450
NLVHQGLQLQ LDPAVPGVYS GNPYPFGIDP IWNIAQNKLT FLNSYKMKMS
460 470 480 490 500
VVMGITQMVF GVMLGLLNHI NFKRPINIIL QFIPEMIFII CLFGYLVFMI
510 520 530 540 550
IFKWCKYDVH SSQGAPSILI HFINMFLFNY SDPTNAPLYE HQKEVQTFLV
560 570 580 590 600
IFALIAVPWM LLIKPFVLRA NHLKAQRMGV INFWKLQSSS GPEDHAELTD
610 620 630 640 650
VENAHANHKS KKEFDFGDIF VHQAIHTIEY CLGCISNTAS YLRLWALSLA
660 670 680 690 700
HAQLSEVLWT MVMHQGLSIG GYGGLIGVFI IFAAFAVLTV AILLVMEGLS
710 720 730 740
AFLHALRLHW VEFQNKFYAG TGHLFSPFSF QSILEGTDNE
Length:740
Mass (Da):83,856
Last modified:July 27, 2011 - v1
Checksum:i642EA059C5C4D229
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7DPH0F7DPH0_XENTR
V-type proton ATPase subunit a
atp6v0a4
838Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01102827 Genomic DNA No translation available.
AAMC01102828 Genomic DNA No translation available.
AAMC01102829 Genomic DNA No translation available.
AAMC01102830 Genomic DNA No translation available.
AAMC01102831 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000064393; ENSXETP00000062258; ENSXETG00000011571

Entry informationi

Entry nameiF6Y932_XENTR
AccessioniPrimary (citable) accession number: F6Y932
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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