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Entry version 44 (07 Oct 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

DExD/H-box 60 like

Gene

DDX60L

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DExD/H-box 60 likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX60LImported
Synonyms:DDX60Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:49403, DDX60L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6Y6U2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000024062, Expressed in oviduct epithelium and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6Y6U2, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini778 – 945Helicase ATP-bindingInterPro annotationAdd BLAST168
Domaini1236 – 1378Helicase C-terminalInterPro annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 602DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1174 – 1201Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi582 – 601PolyampholyteSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157188

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6Y6U2

TreeFam database of animal gene trees

More...
TreeFami
TF314846

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F6Y6U2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQNNLLFLG LEDHVIFFRK MAKLILSEMP KAKYSSLLND FVESNFFVID
60 70 80 90 100
GDSLLVTCLC DKSFKQGQDL HFFYLVECYL VDLMSNGGQF AIVFFKEAEC
110 120 130 140 150
AYFDFPELLS LRTTLILHLQ HNTNIDVLTE FSGCSSLDWK LFLEEHYPYF
160 170 180 190 200
LVVSEEGLND GQTSFFNFLI IQSWAMGVNV VLSSGQECDI LRFHAYIMQS
210 220 230 240 250
TDRNKKFSKE NETVIQSAYE SLMQHLEERK ILALASHFRR LRWKVMMEEA
260 270 280 290 300
CQTISLLQQL WLEALDIRRV VCVTSCSLAL RMYHRFLGNK ENTASGRETI
310 320 330 340 350
THQVSSNYLP LREAEDLCRL HCLCMAFQLH LPLSQRACSR VIISPWIENV
360 370 380 390 400
CTFLKMKKWC DYFILRNLNL FEGWNLNLNH LSDLCDEHLL KNIAFYYETE
410 420 430 440 450
NTQELHLNLG DSIKRDYTHL WNFVSHLVKE FDVGKPFPLR TTARPFLGKK
460 470 480 490 500
LLPIQDVSLG KIPKVGFIPM TSAIIDKFVG DVMKDLPILK SDAPAVTSLL
510 520 530 540 550
KQKERDELLH WHAHRPLSND YDKTRCLFYE NSRDLPVFNV KKNQSYPQFY
560 570 580 590 600
GKSLESVSSK VIVTQTIQPK EDSWGAKSEI SQQDAKSEKV TRKKKSSLLK
610 620 630 640 650
QDQKEQQQWN DLLFSVEKEL KENLNSGIRK LEDFLKSCKS NSVKIQVEMV
660 670 680 690 700
GLSACFKAWK EHCRDEGRIS KDLSIAVQMM KRIHSLLERY PEILEEDHKF
710 720 730 740 750
IAKCLKYLGF NNLANSLDPT LVTGDDEKRK KKNKYAIDIG PARFQLQYMG
760 770 780 790 800
HYLIRDERND PDPRVQDFIP DTWQREVLDV VDNNESAVIV APTSSGKTYA
810 820 830 840 850
SYYCMEKVLK ESDEGVVVYV APTKVLVGQV AATVQNRFIK KLPPGSALCG
860 870 880 890 900
TFTRDYHYNT LNCQVLITEP ACFEVLLLDP HCQKWVKRLR YVIFDEVHCL
910 920 930 940 950
GGETGGKFWE HLLVMIRCPF LVLSATISNP KLLTEWLQSV KQYWRQEDKM
960 970 980 990 1000
MEEKFISEVK SDQCLNFLKD NLHRDQSYEV RLVLYGERYN DLEKHICSVK
1010 1020 1030 1040 1050
DNDICFDHFH PCAALTTDHI EKYGFPSDLT LSPQDSVQLY DTMVQVWETW
1060 1070 1080 1090 1100
PRAQELSPEE FVLFKNKIVI KKLDARKYEE NLKAELTRWI KNGKVKKAKR
1110 1120 1130 1140 1150
VLKKLSPNLV SSSDDMVKMF PLLVEKLRQM DKLPAIFFCF KSVDVEERAK
1160 1170 1180 1190 1200
SVCAFLENPE RKSCSQTDQC HSYAHDINKK LTKAENKVKR LKKTFGKDKE
1210 1220 1230 1240 1250
ESRKLKLKLT YGAEYVNILN NLKEFLKIPE ECLYADVNAL HTETLEVVFK
1260 1270 1280 1290 1300
RVQLTRKGAE LKALAQRGIG YHHDFMYFKE REFVEILFAE GFITVVTATG
1310 1320 1330 1340 1350
TLALGIHMPC KSVVLAQDSV YLDALNYRQM SGRAGRRGQD LLGDVYFFDI
1360 1370 1380 1390 1400
PMPKIEKLIK SKVPELRGQF PLSITLVLRL MLLASKGDDP EDAMAKVMSV
1410 1420 1430 1440 1450
LKHSLLSFKQ PRAMQMLKLY FLFSFQFLMK EGYLNQKGNP TGFAGLVSHL
1460 1470 1480 1490 1500
HYHEPSNLVF VSFLVSGLFH NLCQPTKKGS KCFSQDVMEK LVLVLANLFG
1510 1520 1530 1540 1550
RRHFPAKFQD TTVKFHQSKV FLEDLPEDFN AALDEYNMKV TEDFASFLLI
1560 1570 1580 1590 1600
VSKLADMKQE YQLPLSKINF AGNECKGSQL VPHLMNCKEG RAAVSPFVCL
1610 1620 1630 1640 1650
SGNSDDDLLQ PATPSHVILR TMGIDHSRAP VLWSQRFDNQ GRRMPLNAYA
1660 1670 1680 1690 1700
LDFYKHGSLI GLVQDNRMNE GEAYLLLKDF ALTIQAISIS LRELCENEED
1710 1720
NVVLAFEQLS ETFFEKLNKV
Length:1,720
Mass (Da):198,549
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF06C00EF2297E52E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5Q2R9A0A5F5Q2R9_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,742Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PG82A0A5F5PG82_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,740Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PLF4A0A5F5PLF4_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GVD9A0A3Q2GVD9_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I573A0A3Q2I573_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YRA8F6YRA8_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PI75A0A5F5PI75_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PZU0A0A5F5PZU0_HORSE
DExD/H-box 60 like
DDX60L DDX60
1,739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000025859; ENSECAP00000021533; ENSECAG00000024062

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6Y6U2

Genome annotation databases

EnsembliENSECAT00000025859; ENSECAP00000021533; ENSECAG00000024062

Organism-specific databases

VGNCiVGNC:49403, DDX60L

Phylogenomic databases

GeneTreeiENSGT00940000157188
HOGENOMiCLU_002305_0_0_1
InParanoidiF6Y6U2
TreeFamiTF314846

Gene expression databases

BgeeiENSECAG00000024062, Expressed in oviduct epithelium and 20 other tissues
ExpressionAtlasiF6Y6U2, baseline

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Y6U2_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Y6U2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 44 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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