UniProtKB - F6Y6J5 (F6Y6J5_HORSE)
Protein
Submitted name:
Collagen type IV alpha 6 chain
Gene
COL4A6
Organism
Equus caballus (Horse)
Status
Functioni
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.ARBA annotation
GO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
GO - Biological processi
- collagen-activated tyrosine kinase receptor signaling pathway Source: GO_Central
- extracellular matrix organization Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Collagen type IV alpha 6 chainImported |
Gene namesi | Name:COL4A6Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:16743, COL4A6 |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- collagen type IV trimer Source: GO_Central
- extracellular matrix Source: GO_Central
- extracellular space Source: GO_Central
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5023928604 | 22 – 1631 | Sequence analysisAdd BLAST | 1610 |
Proteomic databases
PaxDbi | F6Y6J5 |
PRIDEi | F6Y6J5 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000021274, Expressed in synovial membrane of synovial joint and 17 other tissues |
ExpressionAtlasi | F6Y6J5, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1407 – 1631 | Collagen IV NC1InterPro annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 58 – 242 | DisorderedSequence analysisAdd BLAST | 185 | |
Regioni | 483 – 641 | DisorderedSequence analysisAdd BLAST | 159 | |
Regioni | 668 – 697 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 735 – 862 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 914 – 1088 | DisorderedSequence analysisAdd BLAST | 175 | |
Regioni | 1135 – 1154 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1166 – 1398 | DisorderedSequence analysisAdd BLAST | 233 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 214 | Pro-richSequence analysisAdd BLAST | 21 |
Keywords - Domaini
CollagenARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000153991 |
HOGENOMi | CLU_002023_1_0_1 |
InParanoidi | F6Y6J5 |
TreeFami | TF344135 |
Family and domain databases
Gene3Di | 2.170.240.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR001442, Collagen_IV_NC IPR036954, Collagen_IV_NC_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01413, C4, 2 hits PF01391, Collagen, 18 hits |
SMARTi | View protein in SMART SM00111, C4, 2 hits |
SUPFAMi | SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS51403, NC1_IV, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
F6Y6J5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHPGLWLLLV TLCLTEELAG AGEKKSYGKL CGGQDCSGGC KCFPEKGARG
60 70 80 90 100
RPGPIGIQGP TGPQGFAGPS GLSGLKGERG SPGPLGPYGP KGDKGPMGVP
110 120 130 140 150
GFLGINGIPG HPGQPGPRGP PGLDGCNGTQ GAVGFPGPDG YPGLLGPPGL
160 170 180 190 200
PGQKGSKGEP VFAQGSFKGM KGDPGLPGLD GVTGPQGAPG SPGAVGPIGP
210 220 230 240 250
PGAQGPPGPP GFPGPDGNMG LGFQGEKGAK GDVGLPGPAG PPPSTGELEF
260 270 280 290 300
MGFPKGKKGS KGEPGLQGFP GKAGLPGLPG FGITGEKGEK GIPGLPGPRG
310 320 330 340 350
PMGLEGVPGP PGSQGKKGAS GFPGLNGFPG IKGEKGGIGL PGPDVFIDRD
360 370 380 390 400
GAVISGYPGD PGMPGLPGLK GDEGIQGPPG PSGIPGLPAL PGVPGALGPQ
410 420 430 440 450
GVPGMKGDQG NPGRTTIGAV GLPGRDGLPG LPGLPGPPGP AFETGTLQNT
460 470 480 490 500
EPGFPGLRGE RGPKGNPGLK GVKGDSGFCA CDGGVPNTGP PGEPGLPGPP
510 520 530 540 550
GLMGLPGLKG IRGDPGSGGA RGLSGARGLF GTQGPAGPKG EKGEPTVSTG
560 570 580 590 600
LGMPGDQGDP GPQGLPGETG APGKDGIPGL PGLPGLLGDD GQGFPGEKGL
610 620 630 640 650
PGLPGDKGHS GPTGPPGIGL PGSPGPRGLP GDQGLDGLPG QQGLPGLPGI
660 670 680 690 700
TLPCIIPGPY GPSGFPGTPG FPGPKGARGL PGTPGQPGLH GNKGEPGSPG
710 720 730 740 750
LVHLPELPGF PGPRGEKGLP GFPGLPGKDG LPGKVGSPGL PGSKGAPGDI
760 770 780 790 800
FGAEDGAPGE QGLQGLPGDR GFPGDSGFPG PKGLLGKSGL LGPKGERGRP
810 820 830 840 850
GIPGLMGQPG LPGAGGLFGI KGKPGLPGAP GFPGTSGHPG KKGPRGETGP
860 870 880 890 900
PASAGKRGLP GLKGFPGAPG LIGFLGNSGL PGVTGLPGLP GLKGGKGSVG
910 920 930 940 950
LIGFPGMPGL PGIPGASGLK GVPGSPGRVG PSGRTGSPGE KGDRGDPGPV
960 970 980 990 1000
GLPSPRLPML NLQFKGDRGS RGSAGSNGFP GPRGDKGVAG RPGPPGLPGP
1010 1020 1030 1040 1050
PGFPSTIKGL IGRPGLPGPT GLRGLPGLKG SPGITGFPGI PGESGSQGLN
1060 1070 1080 1090 1100
GAPGLPGASG LPGSKGDHGQ TLGISGTPGP KGQPGETGFE GVKGKAGLVG
1110 1120 1130 1140 1150
DVGFPGNKGE DGKVGLSGDV GLPGSPGLPG IAGMRGNPGL PGTPGHPGAT
1160 1170 1180 1190 1200
GPLGPPGLVG IKGPSITGVP GPAGLPGPKG EKGPPGISMG APGKPGMKGQ
1210 1220 1230 1240 1250
KGDRGFPGLQ GSAGLPGAPG LSLPSVIAGQ PGDPGRPGLD GERGRPGPQG
1260 1270 1280 1290 1300
PRGPPGPSSD QGDPGDPGFP GIPGPQGPKG DQGIPGFSGL PGELGLKGFS
1310 1320 1330 1340 1350
GPRGAPGQTP IAEAIQVPPG PMGLPGIDGI PGLTGDPGLQ GPVGLQGSKG
1360 1370 1380 1390 1400
LPGIPGKDGP SGLPGPPGAL GDPGLPGLQG PPGFEGAPGK QGPFGRAGMP
1410 1420 1430 1440 1450
GQSVRVGYTL VKHSQSEQVP LCPIGMSQLW VGYSLLFVEG QEKAHNQDLG
1460 1470 1480 1490 1500
FAGSCLPRFS TMPFIYCNIN EVCHYAGRND KSYWLSTTAP IPMMPVGQTQ
1510 1520 1530 1540 1550
IPQYISRCSV CEAPSQAIAV HSQDITIPRC PLGWRSLWIG YSFLMHTAAG
1560 1570 1580 1590 1600
AEGGGQSLVS PGSCLEDFRA TPFIECSGAR GTCHYFANKY SFWLTTVEER
1610 1620 1630
QQFREEPVSE TLKAGQLHTR VSRCQVCMKS L
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5Q253 | A0A5F5Q253_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,708 | Annotation score: | ||
A0A3Q2KUY0 | A0A3Q2KUY0_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,597 | Annotation score: | ||
A0A5F5PFE8 | A0A5F5PFE8_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,654 | Annotation score: | ||
A0A5F5PFJ0 | A0A5F5PFJ0_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,690 | Annotation score: | ||
A0A5F5PFV4 | A0A5F5PFV4_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,684 | Annotation score: | ||
A0A5F5PJI4 | A0A5F5PJI4_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,651 | Annotation score: | ||
A0A5F5Q288 | A0A5F5Q288_HORSE | Collagen type IV alpha 6 chain | COL4A6 | 1,654 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000023228; ENSECAP00000019225; ENSECAG00000021274 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6Y6J5 |
PRIDEi | F6Y6J5 |
Genome annotation databases
Ensembli | ENSECAT00000023228; ENSECAP00000019225; ENSECAG00000021274 |
Organism-specific databases
VGNCi | VGNC:16743, COL4A6 |
Phylogenomic databases
GeneTreei | ENSGT00940000153991 |
HOGENOMi | CLU_002023_1_0_1 |
InParanoidi | F6Y6J5 |
TreeFami | TF344135 |
Gene expression databases
Bgeei | ENSECAG00000021274, Expressed in synovial membrane of synovial joint and 17 other tissues |
ExpressionAtlasi | F6Y6J5, baseline |
Family and domain databases
Gene3Di | 2.170.240.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR001442, Collagen_IV_NC IPR036954, Collagen_IV_NC_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01413, C4, 2 hits PF01391, Collagen, 18 hits |
SMARTi | View protein in SMART SM00111, C4, 2 hits |
SUPFAMi | SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS51403, NC1_IV, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6Y6J5_HORSE | |
Accessioni | F6Y6J5Primary (citable) accession number: F6Y6J5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | October 7, 2020 | |
This is version 61 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |