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Entry version 52 (05 Jun 2019)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Collagen type XVIII alpha 1 chain

Gene

COL18A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-1442490 Collagen degradation
R-CFA-1592389 Activation of Matrix Metalloproteinases
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000157 Laminin interactions
R-CFA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XVIII alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL18A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 31

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:49781 COL18A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500334574523 – 1500Sequence analysisAdd BLAST1478

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6Y3U7

PRoteomics IDEntifications database

More...
PRIDEi
F6Y3U7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000011817 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 412LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 116DisorderedSequence analysisAdd BLAST78
Regioni136 – 254DisorderedSequence analysisAdd BLAST119
Regioni414 – 1185DisorderedSequence analysisAdd BLAST772
Regioni1280 – 1317DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 74PolarSequence analysisAdd BLAST17
Compositional biasi136 – 154PolarSequence analysisAdd BLAST19
Compositional biasi156 – 170Pro-richSequence analysisAdd BLAST15
Compositional biasi469 – 483PolyampholyteSequence analysisAdd BLAST15
Compositional biasi529 – 570Pro-richSequence analysisAdd BLAST42
Compositional biasi615 – 632Pro-richSequence analysisAdd BLAST18
Compositional biasi660 – 674Pro-richSequence analysisAdd BLAST15
Compositional biasi758 – 778Pro-richSequence analysisAdd BLAST21
Compositional biasi1009 – 1026Pro-richSequence analysisAdd BLAST18
Compositional biasi1078 – 1093PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1135 – 1178Pro-richSequence analysisAdd BLAST44

Keywords - Domaini

CollagenSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158212

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQWTRFA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR010363 DUF959_COL18_N
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 8 hits
PF06121 DUF959, 1 hit
PF06482 Endostatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6Y3U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARHPGRCLL LLLLLTCCPA AAQVDLLSLN WLWSTRTAGP TAEPVSEAPG
60 70 80 90 100
SPHVQPRDET GTPVTPQPGP TEQGNAPASP EPPLRGLETD EHAASAAPSA
110 120 130 140 150
PPAGPDPKEE KEENIAGVGA KILNVAQGIR SFVQLWDDTT RPESSSTAGT
160 170 180 190 200
PAPVTPTSPL ALPGPSRPPP ENGTALWLGS TDAPRVEAST LPAPTRLPPS
210 220 230 240 250
LDRPRAALRE PSGPPPSPES RGSEVGLLQL LGEPPPQQVT QVDDPDVGPA
260 270 280 290 300
FVFGPDANSG QVARYHVPSP FFRDFSLLMH VRPATEGPGV LFAITDAAQA
310 320 330 340 350
VVSVGVKLSG VRDGQQHVQL LYTEPGAART RTAASFRLPA FTGQWTRLAL
360 370 380 390 400
SVDGATVALF VDCELFQRVP LERSPGGLQL EPGAGLFVAQ AGGADPDKFQ
410 420 430 440 450
GMIAELRVRG DPHVSPLHCL EEDDDDSGGV SGDFGSGLED DREPSGLLPK
460 470 480 490 500
AELPEAPPVT SPPLTGGRDV EDSRMEEIEE EATASPLGAR TLPGSATVTA
510 520 530 540 550
ESALALGAAC RSPGIPGPAG ASGGCSRRPQ PVPSPPRPQA PTGPAAHNPE
560 570 580 590 600
AWPGPGPQGP PGPPGPPGKD GTPGRDGEPG DPGEDGRPGD PGPQGFPGTP
610 620 630 640 650
GDVGPKGEKG DPGVGPRGPP GPQGPPGPPG PSFRHDKLTF IDMEGSGFGG
660 670 680 690 700
DLESLRGPRG FPGPPGPPGV PGLPGEPGRF GMNSSDVPGP AGLPGVPGRD
710 720 730 740 750
GPPGLPGAPG AVGSPTRACP PGGVGSRGSR GDAGAPGPKG SKGDPGPIGV
760 770 780 790 800
PGESGLAGPP GPAGPPGPPG PPGPPGPGLA AGFVDMEGSG EPFWSTAHGA
810 820 830 840 850
SGPQGPPGLP GVKGDPGIVG PPGAKGEVGA DGPPGFPGLP GREGTAGAQG
860 870 880 890 900
PKGEKGTQGE KGEPGRDGVG QPGLPGPPGP PGPVVYVSEQ ERAATGVPGP
910 920 930 940 950
EGRPGHAGFP GPAGPKGDLG SKGQRGPPGP KGEKGEPGPA FSPDGSMLAP
960 970 980 990 1000
AQKGAKGEPG FRGPPGPYGR PGHKGEIGFP GRPGRPGMNG LKGEKGEPGQ
1010 1020 1030 1040 1050
ASAGFGMTGP PGPPGPPGPP GPPGTPVYDS NAFMEPGHPG PPGLPGEXGP
1060 1070 1080 1090 1100
SGPKGDKGDL PPGPPGQLPF DLLQLGAEMK GEKGDRGDAG QKGERGEPGG
1110 1120 1130 1140 1150
GGFFGSSVPG PPGPPGYPGI PVSLGSGPQG PGTPARPSGR APPGPPGPPG
1160 1170 1180 1190 1200
PPSFPGPYRQ TISVPGPPGP PGPPGPPGTM GTSSGVRIWA TYQTMLDKVP
1210 1220 1230 1240 1250
DVPEGWLMFV AEREELYVRV RNGFRKVLLE ARVPLPRGTD NEVAALQPPV
1260 1270 1280 1290 1300
VQLHEGNPYP RREPTHATAR PWRADDILAS PPRLLDPQPY PGAPHHGSYV
1310 1320 1330 1340 1350
HFQPARPTGG PVHTHTHTHQ DFQPVLHLVA LNSPQPGGMR GIRGADFQCF
1360 1370 1380 1390 1400
QQARAAGLAG TFRAFLSSRL QDLYSIVRRA DRTGVPVVNL RDEVLFPSWE
1410 1420 1430 1440 1450
ALFSGSEGQL KPGARIFSFD GRDVLQHPAE RRRGVWPGGA PSGRRLTDSY
1460 1470 1480 1490 1500
CETWPLEAPA ATGQASSLLA GRLLEQEAAS CRHAFVVLCI ENSVMTSFSK
Length:1,500
Mass (Da):151,746
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA366D1393317AF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9P8D3J9P8D3_CANLF
Collagen type XVIII alpha 1 chain
COL18A1
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03016646 Genomic DNA No translation available.
AAEX03016647 Genomic DNA No translation available.
AAEX03016648 Genomic DNA No translation available.
AAEX03016649 Genomic DNA No translation available.
AAEX03016650 Genomic DNA No translation available.
AAEX03016651 Genomic DNA No translation available.
AAEX03016652 Genomic DNA No translation available.
AAEX03016653 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000018820; ENSCAFP00000017439; ENSCAFG00000011817

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03016646 Genomic DNA No translation available.
AAEX03016647 Genomic DNA No translation available.
AAEX03016648 Genomic DNA No translation available.
AAEX03016649 Genomic DNA No translation available.
AAEX03016650 Genomic DNA No translation available.
AAEX03016651 Genomic DNA No translation available.
AAEX03016652 Genomic DNA No translation available.
AAEX03016653 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

PaxDbiF6Y3U7
PRIDEiF6Y3U7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000018820; ENSCAFP00000017439; ENSCAFG00000011817

Organism-specific databases

VGNCiVGNC:49781 COL18A1

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
GeneTreeiENSGT00940000158212
OMAiGQWTRFA

Enzyme and pathway databases

ReactomeiR-CFA-1442490 Collagen degradation
R-CFA-1592389 Activation of Matrix Metalloproteinases
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000157 Laminin interactions
R-CFA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSCAFG00000011817 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00247 Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR010363 DUF959_COL18_N
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 8 hits
PF06121 DUF959, 1 hit
PF06482 Endostatin, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Y3U7_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Y3U7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 5, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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