UniProtKB - F6Y0D9 (F6Y0D9_HORSE)
Protein
Cadherin-1
Gene
CDH1
Organism
Equus caballus (Horse)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins.UniRule annotation
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- synapse assembly Source: GO_Central
Keywordsi
Biological process | Cell adhesionUniRule annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-1ARBA annotationAlternative name(s): E-Cad/CTF1ARBA annotation E-Cad/CTF2ARBA annotation E-Cad/CTF3ARBA annotation Epithelial cadherinARBA annotation |
Gene namesi | Name:CDH1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:16315, CDH1 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network ARBA annotation
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- catenin complex Source: GO_Central
- flotillin complex Source: GO_Central
Other locations
- apical junction complex Source: GO_Central
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 709 – 733 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5018550642 | 23 – 900 | Cadherin-1Sequence analysisAdd BLAST | 878 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotationProteomic databases
PaxDbi | F6Y0D9 |
PRIDEi | F6Y0D9 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000021418, Expressed in trophoblast and 19 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 181 – 263 | CadherinInterPro annotationAdd BLAST | 83 | |
Domaini | 264 – 376 | CadherinInterPro annotationAdd BLAST | 113 | |
Domaini | 377 – 487 | CadherinInterPro annotationAdd BLAST | 111 | |
Domaini | 488 – 596 | CadherinInterPro annotationAdd BLAST | 109 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157175 |
HOGENOMi | CLU_005284_2_1_1 |
InParanoidi | F6Y0D9 |
TreeFami | TF316817 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F6Y0D9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPPCRSLSA LLLLLQVSSR LCQEPEPCRP GFGAQSYTFT VPRRHLERGR
60 70 80 90 100
VLGRVSFEGC TGQPRTVYAS DDTRFRVGTD GVVMVKRPLQ LHNPEMSFLV
110 120 130 140 150
HAWDSSRRKL STKVTVKAAT HEHHRHHHHH EAVSGTHTEV LTFPSSHHGL
160 170 180 190 200
RRQKRDWVIP PISCPENEKG PFPKNLVQIK SNRDKETKVF YSITGQGADT
210 220 230 240 250
PPVGVFIIER ETGWLKVTEP LDREEISKYI LFSHAVSSNG NAIEDPMEIV
260 270 280 290 300
ITVTDQNDNK PEFTQLVFEG SVMEGALPGT SVMQVTATDA DDDVNTYNAA
310 320 330 340 350
IVYSILSQEP MLPHKQMFTI NRDTGVISVL TTGLDRESFP TYTLVVQAAD
360 370 380 390 400
LQGEGLSTTA TAVITVTDAN DNPPVFNPTL YEGQVPENQA DVLITRLKVT
410 420 430 440 450
DADVPNTPAW EAVYTILNDN EQQFVVTTDP VTNEGILKTA KGLDFEAKQQ
460 470 480 490 500
YNLFVTVKNV APFEVTLSTS TATVTVDVMD VNEAPIFVPP QKRVEVPEDF
510 520 530 540 550
GVGLEITSYT AQDPDKFMEQ KITYRIWRDA ANWLKINPDT GAISTQAELD
560 570 580 590 600
RENLEHVKNS TYTALIIATD NGSPLATGTG TLLLILSDVN DNGPIPEPRN
610 620 630 640 650
MDFCQKDPQP HIINIIDPDL PPNTSPFTAE LTHGASVNWT IEYNDPAHES
660 670 680 690 700
LVLKPKKILE LGDYKINLKL MDNQNKDQVT TLDVAVCDCE GAVTNCGRNR
710 720 730 740 750
QVAEAGLQVS AILGILGGIL ALLLLILLLL LFLRRRGVVK EPLLPPEDDT
760 770 780 790 800
RDNVYYYDEE GGGEEDQDFD LSQLHRGLDA RPEVIRNDVA PTLLSVPQYR
810 820 830 840 850
PRPANPDEIG NFIDENLKAA DSDPTAPPYD SLLVFDYEGS GSEAATLSSL
860 870 880 890 900
NSSESDQDQN YDYLNEWGNR FKKLADMSSL MQKSLGPCRA IALCLSLAIS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PMP3 | A0A5F5PMP3_HORSE | Cadherin-1 | CDH1 | 823 | Annotation score: | ||
A0A5F5PQI6 | A0A5F5PQI6_HORSE | Cadherin-1 | CDH1 | 884 | Annotation score: | ||
A0A5F5PWA4 | A0A5F5PWA4_HORSE | Cadherin-1 | CDH1 | 849 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000023257; ENSECAP00000019251; ENSECAG00000021418 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6Y0D9 |
PRIDEi | F6Y0D9 |
Genome annotation databases
Ensembli | ENSECAT00000023257; ENSECAP00000019251; ENSECAG00000021418 |
Organism-specific databases
VGNCi | VGNC:16315, CDH1 |
Phylogenomic databases
GeneTreei | ENSGT00940000157175 |
HOGENOMi | CLU_005284_2_1_1 |
InParanoidi | F6Y0D9 |
TreeFami | TF316817 |
Gene expression databases
Bgeei | ENSECAG00000021418, Expressed in trophoblast and 19 other tissues |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6Y0D9_HORSE | |
Accessioni | F6Y0D9Primary (citable) accession number: F6Y0D9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |