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Entry version 34 (31 Jul 2019)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Transmembrane protein 245

Gene

TMEM245

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane protein 245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:47551 TMEM245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei129 – 153HelicalSequence analysisAdd BLAST25
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei223 – 244HelicalSequence analysisAdd BLAST22
Transmembranei264 – 285HelicalSequence analysisAdd BLAST22
Transmembranei292 – 309HelicalSequence analysisAdd BLAST18
Transmembranei315 – 333HelicalSequence analysisAdd BLAST19
Transmembranei425 – 446HelicalSequence analysisAdd BLAST22
Transmembranei531 – 553HelicalSequence analysisAdd BLAST23
Transmembranei702 – 718HelicalSequence analysisAdd BLAST17
Transmembranei724 – 742HelicalSequence analysisAdd BLAST19
Transmembranei789 – 809HelicalSequence analysisAdd BLAST21
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21
Transmembranei847 – 866HelicalSequence analysisAdd BLAST20
Transmembranei886 – 907HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6XY57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000002837 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000004194

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 117DisorderedSequence analysisAdd BLAST44
Regioni368 – 412DisorderedSequence analysisAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2365 Eukaryota
ENOG410XRXR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001667

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6XY57

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFWKPEN

TreeFam database of animal gene trees

More...
TreeFami
TF315224

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002549 AI-2E-like

The PANTHER Classification System

More...
PANTHERi
PTHR21716 PTHR21716, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01594 AI-2E_transport, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6XY57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPETCYLA PQEPMGEGAL SPLSGSCSSR WVSCALGAQR GTTTSTMPRA
60 70 80 90 100
ARLASLPCLP LRFPAPPLGG RSWGAMADGA GPAEAPSPRG SPGRAPRVPR
110 120 130 140 150
PGGGGGGGGG EPPRTPALAL RFDKPIKQAF YNTGAVLFVC LCCGAAVLVY
160 170 180 190 200
FILEAFLRPL LWAVLCGTFL HPFKSSLTRL GRHWLQRLHR AHTPIVLAAL
210 220 230 240 250
LLPLCFADYG VEALGEQALR RRRLLLLLGA GGPLLYGLYS LGSYLGVQVL
260 270 280 290 300
LAYAGALICR GLDYFSSLWI WTLVVGYVLT VSFKWNASTE RYLRAVSIPV
310 320 330 340 350
WIILLFHLAS LAGSWRIPVF LVIVFLMSVG TLYEKQNGKE SSGAELPGQV
360 370 380 390 400
ISMAASTLAT LAISITGYES SSEDQPSTEP AETMDRGEPP PALSSTPSPS
410 420 430 440 450
SPSPTLGRQR PEMGTFVRKK KTSDIYFVSL VWAIIGVQLW LNLWIVQLLP
460 470 480 490 500
VPIAVWILKK LVIHFGVVDF LEKRCLVWWQ AVEHFLRERQ EALAPWPVVG
510 520 530 540 550
LGKFLLKVDS KLWHWLNKKM IIWLEKMLDK IISIFIIFLL VIGTLLLALL
560 570 580 590 600
LTAKVHQESV HMIEVTSNLI NETLANHPEW ANWLPEAQVV QRALNSAANN
610 620 630 640 650
VYQYGREWIT HKLHKILGDK VNNTAMIEKQ VLELWDRLYH SWFVKNVTHS
660 670 680 690 700
GRHKGHKMHI NRQNSWLGDI LDWQDIASFV HENIETFLSI LESLWIVMSR
710 720 730 740 750
NVSLLFTTVT TLLTILFYSG TALLNFVLSL IIFLTTLFYL LSSSDEYYKP
760 770 780 790 800
VKWVISLTPL SQPGPSSNII GQSVEEAIRG VFDASLKMAG FYGLYTWLTH
810 820 830 840 850
TIFGINIVFI PSALAAILGA VPFLGTYWAA VPAVLDLWLT QGLGCKAILL
860 870 880 890 900
LVFHLLPTYF VDTAIYSDIS GGGHPYLTGL AVAGGAYYLG LEGAIIGPIL
910 920 930 940 950
LCILVVASNI YSAMLMSPTN SVPTPNQTPW PAQTQRTFHD ISDDLKSSVD
Length:950
Mass (Da):104,659
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE2D276CF68D28F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03008036 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000004537; ENSCAFP00000004194; ENSCAFG00000002837

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008036 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000004194

Proteomic databases

PaxDbiF6XY57

Genome annotation databases

EnsembliENSCAFT00000004537; ENSCAFP00000004194; ENSCAFG00000002837

Organism-specific databases

VGNCiVGNC:47551 TMEM245

Phylogenomic databases

eggNOGiKOG2365 Eukaryota
ENOG410XRXR LUCA
GeneTreeiENSGT00390000001667
InParanoidiF6XY57
OMAiFFWKPEN
TreeFamiTF315224

Gene expression databases

BgeeiENSCAFG00000002837 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR002549 AI-2E-like
PANTHERiPTHR21716 PTHR21716, 1 hit
PfamiView protein in Pfam
PF01594 AI-2E_transport, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XY57_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XY57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: July 31, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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