UniProtKB - F6XWV7 (F6XWV7_HORSE)
Protein
Submitted name:
Phosphatidylinositol 4-kinase alpha
Gene
PI4KA
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- phosphatidylinositol-mediated signaling Source: InterPro
- phosphatidylinositol phosphorylation Source: InterPro
Keywordsi
Molecular function | KinasePROSITE-ProRule annotationARBA annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Phosphatidylinositol 4-kinase alphaImported |
Gene namesi | |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:50961, PI4KA |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023152, Expressed in prefrontal cortex and 23 other tissues |
ExpressionAtlasi | F6XWV7, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1531 – 1719 | PIK helicalInterPro annotationAdd BLAST | 189 | |
Domaini | 1846 – 2103 | PI3K/PI4KInterPro annotationAdd BLAST | 258 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00550000074798 |
HOGENOMi | CLU_000893_2_0_1 |
InParanoidi | F6XWV7 |
TreeFami | TF102041 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00613, PI3Ka, 1 hit |
SMARTi | View protein in SMART SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F6XWV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPRLRRELW RSRAGCWRPA GCAAARAMMA AAAARGGGGG GAGGSSSGSG
60 70 80 90 100
SGSSASRGFY FNTVLSLARS LAVQRPASLD KVQKLLCMCP VDFHGIFQLD
110 120 130 140 150
ERRRDAVIAL GIFLIESDLQ HKDSVVPYLL RLLKGLPKVY WVEESTARKG
160 170 180 190 200
RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEALLQVL HVLLGMCQAL
210 220 230 240 250
EIQEKEYLCK YAIPCLIGIS RAFGRYSNTE ESLLSKLFPK VPPHSLRVPE
260 270 280 290 300
ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP
310 320 330 340 350
PPSSPGGSAF HCFEVSYLPD GSALEPDYYF STISSSFSVS PLFNGITYKE
360 370 380 390 400
FNIPLEMLRE LLNLVKKIVE EPVLKSLDAV VASVIEANPS ADLYYSTFSD
410 420 430 440 450
PLYVAMFKML RDTLYYMKDL PTSFVKEIHD FVLEQFNMSQ GELQKILHDA
460 470 480 490 500
DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK LSEKLQSKTS
510 520 530 540 550
SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VVPSPVLVKL
560 570 580 590 600
YKCHSQYHTV AGNDIKISVT NEHSEPTLNV MSGKKSQPSM YEQLRDIAID
610 620 630 640 650
NICRCLKAGL TVDAVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG
660 670 680 690 700
HIAVALRDTP KVMEPILQIL QQKFCQPPSP LDVLIIDQLG CLVITGNQYI
710 720 730 740 750
YQEVWNLFQQ ISVKASSVVY SATKDYKDHG YRHCSLAVIN ALANIAANIQ
760 770 780 790 800
DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS SSAGNLGVLI
810 820 830 840 850
PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE
860 870 880 890 900
GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL
910 920 930 940 950
LDPAPEVSAL INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE
960 970 980 990 1000
DKAIQKDKSG MMQCVIAVAD KVFDAFLNMM ADKAKTKENE EELERHAQFL
1010 1020 1030 1040 1050
LVNFNHIHKR IRRVADKYLS GLVDKFPHLL WSGTVLKTML DILQTLSLSL
1060 1070 1080 1090 1100
SADIHKDQPY YDIPDAPYRI TVPDTCEARE SIVKDFAARC GMILQEAMKW
1110 1120 1130 1140 1150
APTVTKSHLQ ATQLTERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSD
1160 1170 1180 1190 1200
ATGQISDLNK MMVQELNTAL DLGNAQNYTQ AMFKLTAMLI SSKDCDPQLL
1210 1220 1230 1240 1250
HHLCWGPLRM FNEHGMETAL ACWEWLLAGK NGVEVPFMRE MSGAWQMTVE
1260 1270 1280 1290 1300
QKFGLFSAEI KEADPLAASE ASQPKPCAPE VTPHYIWIDF LVQRFEIAKY
1310 1320 1330 1340 1350
CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK CPLRSPDLAE
1360 1370 1380 1390 1400
TRLLTLGLSL LHADVVPNAT IRNVLREKIY STAFDYFSCP PKFPTQGEKR
1410 1420 1430 1440 1450
LREDISIMIK FWTAMFSDKK YLTASQLVPP DNQDTRSNLD IAVGSRQQAT
1460 1470 1480 1490 1500
QGWINTYPLS SGMSTISKKS GMSKKTNRGS QLHKYYMKRR TLLLSLLATE
1510 1520 1530 1540 1550
IERLITWYNP LSAPELELDQ AGENSVANWR SKYISLSEKQ WKDNVNLAWS
1560 1570 1580 1590 1600
ISPYLAVQLP ARFKNTEAIG NEVTRLVRLD PGAVSDIPEA IKFLVTWHTI
1610 1620 1630 1640 1650
DADAPELSHV LCWAPADPPT GLSYFSSMYP PHPLTAQYGV KVLRSFPPDA
1660 1670 1680 1690 1700
ILFYIPQIVQ ALRYDKMGYV REYILWAASK SQLLAHQFIW NMKTNIYLDE
1710 1720 1730 1740 1750
EGHQKDPDIG DLLEQLVEEI TGSLSGPAKD FYQREFDFFN KITNVSAIIK
1760 1770 1780 1790 1800
PYPKGDERKK ACLSALSEVK VQPGCYLPSN PEAIVLDIDY KSGTPMQSAA
1810 1820 1830 1840 1850
KAPYLAKFKV KRCGVSELEK EGLRCCSDSE DEHGAQEADG QKISWQAAIF
1860 1870 1880 1890 1900
KVGDDCRQDM LALQIIDLFK NIFQLVGLDL FVFPYRVVAT APGCGVIECI
1910 1920 1930 1940 1950
PDCTSRDQLG RQTDFGMYDY FTRQYGDEST LAFQQARYNF IRSMAAYSLL
1960 1970 1980 1990 2000
LFLLQIKDRH NGNIMLDKKG HIIHIDFGFM FESSPGGNLG WEPDIKLTDE
2010 2020 2030 2040 2050
MVMIMGGKME ATPFKWFMEM CVRGYLAVRP YMDAVVSLVT LMLDTGLPCF
2060 2070 2080 2090 2100
RGQTIKLLKH RFSPNMTERE AANFIMKVIQ SCFLSNRSRT YDMIQYYQND
IPY
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HGD1 | A0A3Q2HGD1_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,152 | Annotation score: | ||
A0A3Q2HSD4 | A0A3Q2HSD4_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 212 | Annotation score: | ||
F7A2S7 | F7A2S7_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 154 | Annotation score: | ||
F6XWL5 | F6XWL5_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,100 | Annotation score: | ||
F6YDZ7 | F6YDZ7_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,143 | Annotation score: | ||
A0A3Q2H168 | A0A3Q2H168_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,118 | Annotation score: | ||
A0A3Q2H786 | A0A3Q2H786_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,098 | Annotation score: | ||
A0A3Q2HIW7 | A0A3Q2HIW7_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 1,992 | Annotation score: | ||
A0A3Q2HP36 | A0A3Q2HP36_HORSE | Phosphatidylinositol 4-kinase alpha | PI4KA UBE2L3 | 2,093 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025688; ENSECAP00000021382; ENSECAG00000023152 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6XWV7 |
Genome annotation databases
Ensembli | ENSECAT00000025688; ENSECAP00000021382; ENSECAG00000023152 |
Organism-specific databases
VGNCi | VGNC:50961, PI4KA |
Phylogenomic databases
GeneTreei | ENSGT00550000074798 |
HOGENOMi | CLU_000893_2_0_1 |
InParanoidi | F6XWV7 |
TreeFami | TF102041 |
Gene expression databases
Bgeei | ENSECAG00000023152, Expressed in prefrontal cortex and 23 other tissues |
ExpressionAtlasi | F6XWV7, baseline |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00613, PI3Ka, 1 hit |
SMARTi | View protein in SMART SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6XWV7_HORSE | |
Accessioni | F6XWV7Primary (citable) accession number: F6XWV7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 61 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |