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UniProtKB - F6XWR7 (F6XWR7_HORSE)

Entry version 56 (12 Aug 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Serine peptidase inhibitor, Kunitz type 1

Gene

SPINT1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Serine peptidase inhibitor, Kunitz type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPINT1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:23524, SPINT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei751 – 773HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi620 ↔ 632PROSITE-ProRule annotation
Disulfide bondi627 ↔ 645PROSITE-ProRule annotation
Disulfide bondi639 ↔ 654PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6XWR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000023874, Expressed in trophoblast and 16 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6XWR7, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini359 – 442MANSCInterPro annotationAdd BLAST84
Domaini551 – 601BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini676 – 726BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 268DisorderedSequence analysisAdd BLAST208
Regioni782 – 804DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 100PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161683

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032314_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6XWR7

TreeFam database of animal gene trees

More...TreeFami		TF325867

Family and domain databases

Conserved Domains Database

More...CDDi		cd00109, KU, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.400.10, 1 hit
4.10.410.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1

The PANTHER Classification System

More...PANTHERi		PTHR46750, PTHR46750, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F6XWR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASASHSGRK EGFLELARAG TLEQASRIPL IKGAATQLLG SLPATRWKCF 
        60         70         80         90        100
PRADADGEIV CIGLSPKSPP PAPSPAPQAW GWKRGPDQKG RQEATRQIAR 
       110        120        130        140        150
PSRARRRGSF PAGSGPPRSA STSGARGLPA RLDSVEPADS SLEGCAPVPV 
       160        170        180        190        200
APGPQSPLGD PTAGEWGWRA GQSGSSPGRG GRGAPGMGGA SGTRVNVRPA 
       210        220        230        240        250
PTALTQFHQK LGGGGGRSSA PGSGAEAAGR AAQEGGTGTS AGPAPPHSPA 
       260        270        280        290        300
QVTRARRAPR RRQSRTEHVW PFVLRPRVRP GLKHPWGPEA RTVKVTPVGR 
       310        320        330        340        350
RATAPGRMMA GAHLSQALIP AVLVWLLCEL GLRGTQAGQP PEPPGLPAGP 
       360        370        380        390        400
ACLDRFTAGV PDFVLDTEAS VSNGATFLGS PTVRRGWDCV RACCTTQNCN 
       410        420        430        440        450
LALVELHSDG GEDAIATCFL MDCLYEQNFV CKFAPREGFI NYLTREVYRS 
       460        470        480        490        500
YRELRTQGFG GSGIPRIWAG VDLKVQPQEP LVLKGVGTTD WHLLQGDTDV 
       510        520        530        540        550
RVEKNDLDQV ELWGLKEGAY LFQLRAGSDQ PDSTTNITIT VLSAKQTEEY 
       560        570        580        590        600
CLASSKVGRC RGSFPRWYYD PTEQICKSFV YGGCLGNKNN YLREEECKLA 
       610        620        630        640        650
CRDVQGPSVE RHHPVCSGTC PSTKFRCSDG CCIDSFLECD DTPDCPDASD 
       660        670        680        690        700
EATCDKYTSG FEELQNIHFR SDKGHCVDLP DTGLCLESIP RWYYNPFSER 
       710        720        730        740        750
CARFTYGGCY GNKNNFEEEQ QCLESCRGIS KKDVFGLRRE SHIPSVGSVE 
       760        770        780        790        800
VAVAVLLVTC IVVVVAILGY CFIKNQRKSF HRHHHRRPPP PTPTSSTVST 
       810        820        830        840        850
TEDTEHLVEA GLGKTLGLDS SSLFPGTILP QRPGLQPHLK VSQLCSGRLL 
       860 
LRKLKGPRGA ENL
Length:863
Mass (Da):92,882
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B9DD4FD15BD6C56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2IKF1A0A3Q2IKF1_HORSE
Serine peptidase inhibitor, Kunitz ...
SPINT1
816Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H2E8A0A3Q2H2E8_HORSE
Serine peptidase inhibitor, Kunitz ...
SPINT1
847Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IDK1A0A3Q2IDK1_HORSE
Serine peptidase inhibitor, Kunitz ...
SPINT1
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000025692; ENSECAP00000021386; ENSECAG00000023874

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6XWR7

Genome annotation databases

EnsembliENSECAT00000025692; ENSECAP00000021386; ENSECAG00000023874

Organism-specific databases

VGNCiVGNC:23524, SPINT1

Phylogenomic databases

GeneTreeiENSGT00940000161683
HOGENOMiCLU_032314_1_0_1
InParanoidiF6XWR7
TreeFamiTF325867

Gene expression databases

BgeeiENSECAG00000023874, Expressed in trophoblast and 16 other tissues
ExpressionAtlasiF6XWR7, baseline

Family and domain databases

CDDicd00109, KU, 2 hits
cd00112, LDLa, 1 hit
Gene3Di4.10.400.10, 1 hit
4.10.410.10, 2 hits
InterProiView protein in InterPro
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1
PANTHERiPTHR46750, PTHR46750, 1 hit
PfamiView protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit
SUPFAMiSSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XWR7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XWR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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