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Entry version 56 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Cyclin dependent kinase 12

Gene

CDK12

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cyclin dependent kinase 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:16341, CDK12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6XVV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021449, Expressed in trophectoderm and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6XVV6, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini729 – 1022Protein kinaseInterPro annotationAdd BLAST294

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 705DisorderedSequence analysisAdd BLAST705
Regioni1049 – 1103DisorderedSequence analysisAdd BLAST55
Regioni1163 – 1205DisorderedSequence analysisAdd BLAST43
Regioni1222 – 1294DisorderedSequence analysisAdd BLAST73
Regioni1331 – 1362DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 33PolarSequence analysisAdd BLAST17
Compositional biasi36 – 50BasicSequence analysisAdd BLAST15
Compositional biasi85 – 105PolyampholyteSequence analysisAdd BLAST21
Compositional biasi106 – 121BasicSequence analysisAdd BLAST16
Compositional biasi122 – 139PolyampholyteSequence analysisAdd BLAST18
Compositional biasi149 – 167PolyampholyteSequence analysisAdd BLAST19
Compositional biasi174 – 195PolyampholyteSequence analysisAdd BLAST22
Compositional biasi234 – 365PolarSequence analysisAdd BLAST132
Compositional biasi366 – 380BasicSequence analysisAdd BLAST15
Compositional biasi399 – 413PolyampholyteSequence analysisAdd BLAST15
Compositional biasi433 – 457PolyampholyteSequence analysisAdd BLAST25
Compositional biasi463 – 477PolarSequence analysisAdd BLAST15
Compositional biasi478 – 525PolyampholyteSequence analysisAdd BLAST48
Compositional biasi530 – 574Pro-richSequence analysisAdd BLAST45
Compositional biasi575 – 623PolarSequence analysisAdd BLAST49
Compositional biasi642 – 667PolyampholyteSequence analysisAdd BLAST26
Compositional biasi675 – 697Pro-richSequence analysisAdd BLAST23
Compositional biasi1068 – 1083PolarSequence analysisAdd BLAST16
Compositional biasi1191 – 1205PolarSequence analysisAdd BLAST15
Compositional biasi1222 – 1247PolarSequence analysisAdd BLAST26
Compositional biasi1261 – 1286Pro-richSequence analysisAdd BLAST26

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157595

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004166_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6XVV6

TreeFam database of animal gene trees

More...
TreeFami
TF101060

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6XVV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNPERHGGK KDGTGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS
60 70 80 90 100
KDMGLVTAEA APLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR
110 120 130 140 150
GTDRSDRLHK HRHHQHRRSR DLLKTKQTEK EKNQEVSSKS GSLKDRISGS
160 170 180 190 200
SKRSNEENDD HGKAQLSKSS SNKESRSSKL HKEKTRKERE LKSGHKDRSK
210 220 230 240 250
SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SPKQDDSPSG ASYGQDYDLS
260 270 280 290 300
PPRSHTSSNY DSYKKSPGST SRRQSISPPY KEPSAYQSST RSPSPYGRRQ
310 320 330 340 350
RSVSPYSRRR SSSYERSGSY SGRSPSPYGR RRSSSPFMTK RSLSRSPLPS
360 370 380 390 400
RKSMKSRSRS PAYSRHSSSH SKKKRSGSRS RHSSISPVRL PLNSSLGAEL
410 420 430 440 450
SRKKKERAAA AAAAKMDGKE SKGSPTFLPR KENSSVESKD SGLESKKLPR
460 470 480 490 500
GVKVEKSAPD TELVNVTHLN TEVKNSLDTG KVKLDENSEK HPVLKDSKAQ
510 520 530 540 550
GTRDSKLVAL KEEIVTPKET ETSEKETPPP LPTVISPPPP LPTTTPPPQT
560 570 580 590 600
PPLPPLPPLP AIPQQPPLPP PQPAFSQVLA SSSSTLAPST HPRTSAVSSQ
610 620 630 640 650
ANSQPPVQVS VKTQVSLTAA IPHLKTSTLP PLPLPPLLPG DDDMDSPKET
660 670 680 690 700
LPSKPVKKEK EQRPRHLLTD LPLPPELPGG DPSPPDSPEP KAITPPQQPY
710 720 730 740 750
KKRPKICCPR YGERRQTESD WGKRCVDKFD IIGIIGEGTY GQVYKAKDKD
760 770 780 790 800
TGELVALKKV RLDNEKEGFP ITAIREIKIL RQLIHRSVVN MKEIVTDKQD
810 820 830 840 850
ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VHFSEDHIKS FMKQLMEGLD
860 870 880 890 900
YCHKKNFLHR DIKCSNILLN NSGQIKLADF GLARLYNSEE SRPYTNKVIT
910 920 930 940 950
LWYRPPELLL GEERYTPAID VWSCGCILGE LFTKKPIFQA NLELAQLELI
960 970 980 990 1000
SRLCGSPCPA VWPDVIKLPY FNTMKPKKQY RRRLREEFSF IPSAALDLLD
1010 1020 1030 1040 1050
HMLTLDPSKR CTAEQTLQSD FLKDVELSKM DPPDLPHWQD CHELWSKKRR
1060 1070 1080 1090 1100
RQRQSGVVVE EPPPSKASRK ETTSGTSAEP VKNSSPAPPQ PAPGKVEPGA
1110 1120 1130 1140 1150
GDAIGLGDIT QQLNQSELAV LLNLLQSQTD LSIPQMAQLL NIHSNPEMQQ
1160 1170 1180 1190 1200
QLEALNQSIS ALTEATSQQQ NSEPVAPEES LKEAPPAPVV QPSAEQTTPE
1210 1220 1230 1240 1250
TSSTPADMQN MLAVLLSQLM KTQEPSGNLE ENNSDKNSGS QGPRRTPTMP
1260 1270 1280 1290 1300
QEEAAACPPH ILPPEKRPPE PPGPPPPPPP PPLVEGDLSS APQELNPAVT
1310 1320 1330 1340 1350
AALLQLLTQP EAEPSGHLPH EHQALRSMEY STRPHPNRTY GNTDGPETGF
1360 1370 1380 1390 1400
SATDTDERNS GPALTESLAQ TLVKNRTFSG SVSHLGESSS YQGTGWQQQQ
1410 1420
EGWPLRNLMS ISHLASGALT SSLFHRL
Length:1,427
Mass (Da):157,991
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD097F0EF677A9871
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2I0I5A0A3Q2I0I5_HORSE
Cyclin dependent kinase 12
CDK12
1,370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000023062; ENSECAP00000019089; ENSECAG00000021449

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6XVV6

Genome annotation databases

EnsembliENSECAT00000023062; ENSECAP00000019089; ENSECAG00000021449

Organism-specific databases

VGNCiVGNC:16341, CDK12

Phylogenomic databases

GeneTreeiENSGT00940000157595
HOGENOMiCLU_004166_2_1_1
InParanoidiF6XVV6
TreeFamiTF101060

Gene expression databases

BgeeiENSECAG00000021449, Expressed in trophectoderm and 22 other tissues
ExpressionAtlasiF6XVV6, baseline

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XVV6_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XVV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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