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UniProtKB - F6XSF3 (F6XSF3_CIOIN)

Entry version 52 (16 Jan 2019)
Sequence version 2 (18 Apr 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • deoxyribonuclease I activity Source: GO_Central
  • pre-miRNA binding Source: Ensembl
  • ribonuclease III activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7719 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Tunicata › Ascidiacea › Enterogona › Phlebobranchia › Cionidae › Ciona
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008144 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7719.ENSCINP00000017117

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 209Helicase ATP-bindingInterPro annotationAdd BLAST177
Domaini424 – 587Helicase C-terminalInterPro annotationAdd BLAST164
Domaini615 – 711Dicer dsRNA-binding foldInterPro annotationAdd BLAST97
Domaini892 – 1037PAZInterPro annotationAdd BLAST146
Domaini1281 – 1350RNase IIIInterPro annotationAdd BLAST70
Domaini1625 – 1783RNase IIIInterPro annotationAdd BLAST159
Domaini1808 – 1872DRBMInterPro annotationAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0701 Eukaryota
COG0571 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156287

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6XSF3

Identification of Orthologs from Complete Genome Data

More...OMAi		PKPDQPC

TreeFam database of animal gene trees

More...TreeFami		TF330258

Family and domain databases

Conserved Domains Database

More...CDDi		cd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00358 DSRM, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6XSF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSGSSQEP GKPSWTSNSQ CNSFIPRPYQ IELLECAAKQ NTIICLNGDF 
        60         70         80         90        100
GKCFMYTMFL REVIIKHNGK LNNAPKFAVL LLKEDCMVNE QSELLRSHLD 
       110        120        130        140        150
VDIISCTHNM TDSFTDESLQ QLCHDHQVLV CTPEVFVKLL SISLYIAQYM 
       160        170        180        190        200
DLVIFDDCHL VNIEMHPIRK IMKILDENRY TPMILGLTSS LLNNNITADE 
       210        220        230        240        250
LNKCIHSMET VMHCKAQTAT DLIAVDRHNI NPPVENIILS SDENKDGLNS 
       260        270        280        290        300
QLLSDIRKIL NGALEWLNSC QKEKQEEDLD VCTVAIQLIN ESLMVADVLG 
       310        320        330        340        350
PWCVYQLIVV VLKQLQKNLH LINVHAVMLQ YVQTKFKMVY SICHWYMGDQ 
       360        370        380        390        400
KAVNLAFVAP KVHRLIQVLK EYKPVVEGEE KQNTSFKYNN RNESDYVSWW 
       410        420        430        440        450
QDSDAEDEDA DMMEGKKEEK EDENHPSLFI NTLCGIVFVE ERYVAMMLQR 
       460        470        480        490        500
LLRELSKEDK NLKHVSSSHL TPGVEGERRG VDPASMDQSK QEEVLRKFRS 
       510        520        530        540        550
HESNLLICTG DLEDCAYMPK CNLIMRFDVP KSYRSYAESK SRARAQTSAY 
       560        570        580        590        600
VMLVRETEKS HFMEKLQEYK KIEKVLLGPD WSLNEVYDNN EDDDIEEMIP 
       610        620        630        640        650
PYILNRNTQV NMKNAVRIVN RYCNRLPSDP FTHLSPRCEV VEVLNDGDSP 
       660        670        680        690        700
MFMCILQLPI NSHVREPVQG IVMPTLQLAQ QAVAMETCKV LYEAGELDEN 
       710        720        730        740        750
LMPIGKETVK YAEELDPWKR EVSSITGRPG STKKRQTYNK DSPQILRSCL 
       760        770        780        790        800
PQPDINLFIY EIEMKIKNPL LDELNVRRRK LFFPEETSRC FGILTTKPIP 
       810        820        830        840        850
QIPGFPIFTR SGEESAKLKF CRGFVQLSAQ QIKLVRIFHR YVFSDMLRVD 
       860        870        880        890        900
RVPLSFQPEK STSQLLVVVL NKANSSQLNI DWSFMMKTES KRRVIEKMKS 
       910        920        930        940        950
DPWYKHKMNE QNKVFVFNRQ LYEDGVVVAK YRSCDQPNRF YVAELKDDMT 
       960        970        980        990       1000
PLSSFPSSEY ESFLHYYQLK YGLDIRCLKQ PLLDVDHTSS RLNLLTPRHL 
      1010       1020       1030       1040       1050
NQKGKALPMS SLEKKRAKYE SLHNRQILVP ELCEVHPIPA SLWRKAVCLP 
      1060       1070       1080       1090       1100
SVLYRVNQLL IAEELRKNIA FKSGITMEQP PIGNMWQNLH FGWTDNEDSD 
      1110       1120       1130       1140       1150
DDNVDEISSE NNEVLNENKN VFDENIPKVP NSVENDGECA QHDNLEETNH 
      1160       1170       1180       1190       1200
KQNQHVDFEN STAKSDVYKT TVINHMKENH DEDDYVHVHG SNDVNVHKKN 
      1210       1220       1230       1240       1250
INHDNDSDRI GDTAHDYEAH FDLSDHEDEN MKNNVNDSLA SIRGCKKKIK 
      1260       1270       1280       1290       1300
DVENPIWISS DVIDDYNKEN PVKNLGPGPG LILQALTLSN ASDGFNLERL 
      1310       1320       1330       1340       1350
EMLGDSFLKH AVTVYLYCTY PESHEGKLSY MRSKKVSNYN LYRIGKQFGL 
      1360       1370       1380       1390       1400
AGKMTGLIFD PTVNWLPTGF VVGASGQGQD SDEDISDDDV EIVDPPPSLP 
      1410       1420       1430       1440       1450
PSTINDEEEI YEEDEIRMID GMLGGCIRTL GGSPKGDNGL FGLGKKISKN 
      1460       1470       1480       1490       1500
IGHALSSHQS MHFTDKAALR RSQLNKQNLE DFVIDTWTPV DASGKPLNNS 
      1510       1520       1530       1540       1550
DPLMLDLHTQ HSLADKSIAD CVEALLGAYL TTCGHRSAQL LLCHLGLNIF 
      1560       1570       1580       1590       1600
YAFKETNVCK TTPFQNTKIS MENINHAFTK VLPKVAQAET SKTVDRFGYL 
      1610       1620       1630       1640       1650
TPPTNKMLEC RPNQQNKLDQ LLVALSGFER KINYTFKNKA YLLQAFTHAS 
      1660       1670       1680       1690       1700
YYYNTVTDCY QRLEFLGDAV LDFLITRHLF NDERHHSPGA LTDLRSALVN 
      1710       1720       1730       1740       1750
NTIFASLAVH YDFHKYFKSI SPELHHIIED FVMYQQKQED AQGMDAHLMR 
      1760       1770       1780       1790       1800
KDEEEGENED VEVPKALGDI FESVAGAIYM DSGMDLSSVW KVYSVMMLPL 
      1810       1820       1830       1840       1850
IEKFSACVPR SPVRELLEME PETAKFSCAE KRYDGKVRVT VEIIGKGRFK 
      1860       1870 
GVGRSYRIAK SAAARRALRY LK
Length:1,872
Mass (Da):214,159
Last modified:April 18, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9713EA509C4651DC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EAAA01000779 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCINT00000017117; ENSCINP00000017117; ENSCING00000008383

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EAAA01000779 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Protein-protein interaction databases

STRINGi7719.ENSCINP00000017117

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCINT00000017117; ENSCINP00000017117; ENSCING00000008383

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
GeneTreeiENSGT00940000156287
InParanoidiF6XSF3
OMAiPKPDQPC
TreeFamiTF330258

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XSF3_CIOIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XSF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 18, 2012
Last modified: January 16, 2019
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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