UniProtKB - F6XS13 (F6XS13_HORSE)
Protein
Hypocretin receptor type 2
Gene
HCRTR2
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- orexin receptor activity Source: GO_Central
GO - Biological processi
- circadian sleep/wake cycle process Source: InterPro
- feeding behavior Source: InterPro
- G protein-coupled receptor signaling pathway Source: GO_Central
- neuropeptide signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Hypocretin receptor type 2ARBA annotationAlternative name(s): Orexin receptor type 2ARBA annotation |
Gene namesi | Name:HCRTR2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18715, HCRTR2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 55 – 80 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 132 – 150 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 171 – 190 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 222 – 244 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 303 – 322 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 342 – 367 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PaxDbi | F6XS13 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000024250, Expressed in trophoblast and 5 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 364 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 294 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT01010000222375 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | F6XS13 |
OMAi | IRSHHDE |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000204, Orexin_rcpt IPR004060, Orexin_rcpt_2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF03827, Orexin_rec2, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01522, OREXIN2R PR01064, OREXINR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F6XS13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP
60 70 80 90 100
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD
110 120 130 140 150
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL
160 170 180 190 200
DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTMLPGL
210 220 230 240 250
ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL
260 270 280 290 300
WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ QTKSRISAVA AEIKQIRARR
310 320 330 340 350
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH
360 370 380 390 400
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHGQ EDRLTRGRTS
410 420 430 440
TESRKSLTTQ ISNFDNISKL SEQVVLTSIS TLPAANGAGP LQNW
Sequence databases
RefSeqi | XP_014590172.1, XM_014734686.1 |
Genome annotation databases
Ensembli | ENSECAT00000026160; ENSECAP00000021801; ENSECAG00000024250 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_014590172.1, XM_014734686.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | F6XS13 |
Genome annotation databases
Ensembli | ENSECAT00000026160; ENSECAP00000021801; ENSECAG00000024250 |
Organism-specific databases
VGNCi | VGNC:18715, HCRTR2 |
Phylogenomic databases
GeneTreei | ENSGT01010000222375 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | F6XS13 |
OMAi | IRSHHDE |
TreeFami | TF315303 |
Gene expression databases
Bgeei | ENSECAG00000024250, Expressed in trophoblast and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000204, Orexin_rcpt IPR004060, Orexin_rcpt_2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF03827, Orexin_rec2, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01522, OREXIN2R PR01064, OREXINR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6XS13_HORSE | |
Accessioni | F6XS13Primary (citable) accession number: F6XS13 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |