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Protein
Submitted name:

Huntingtin

Gene

HTT

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HuntingtinImported
Gene namesi
Name:HTTImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati894 – 924HEATPROSITE-ProRule annotationAdd BLAST31

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA
GeneTreeiENSGT00390000015863

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 2 hits
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
PRINTSiPR00375 HUNTINGTIN
SUPFAMiSSF48371 SSF48371, 6 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

F6XPL5-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQQQPPPP PPPPPPPPPQ LPQPPPQAQP
60 70 80 90 100
LLPQPQPPPP PPPPPPGPAA AEEPLHRPKK ELSATKKDRV NHCLTICENI
110 120 130 140 150
VAQSVRNSPE FQKLLGIAME LFLLCSDDAE SDVRMVADEC LNKVIKALMD
160 170 180 190 200
SNLPRLQLEL YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL
210 220 230 240 250
PCLTRTSKRP EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK
260 270 280 290 300
SSSPTIRRTA AGSAVSICQH SRRTHYFYSW LLNVLLGLLV PVEDEHSTLL
310 320 330 340 350
ILGVLLTLRY LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS AEQLIQVYEL
360 370 380 390 400
TLHHTQHQDH NVVTGALELL QQLFRTPPPE LLQALTTVGG IRQLTEAKDE
410 420 430 440 450
SGGRSRSGSI VELIANLKGM LLPYLPGKVL LGEEEALEDD SESRSDVSSS
460 470 480 490 500
AFAASVKDEI SGELTASSGV STPGSAGHDI ITEQPRSQHT LQADSVDLAG
510 520 530 540 550
CDLTSSATDG DEEDILSHSS SQVSAVPSDP AMDLNDGTQA SSPISDSSQT
560 570 580 590 600
TTEGPDSAVT PSDSSEIVLD GADNQYLGPQ IGQPQDEDEE ATSVLPDEAS
610 620 630 640 650
EAFRNSSMAL QQAHLLKNMS HSRQPSDSSV DKFVSRDEAT ESGDQESKPC
660 670 680 690 700
RIKGDIGQST DDDSAPLVHC VRLLSASFLL TGGKNVLVPD RDVRVSVKAL
710 720 730 740 750
ALSCVGAAVA LHPESFFSKL YKVPLDTADY PEEQYVSDIL NYIDHGDPQV
760 770 780 790 800
RGATAILCGT LVCSILSRSR FHVGEWMGTI RTLTGNTFSL ADCVPLLRKT
810 820 830 840 850
LKDESSVTCK LACTAVRHCV MSLCSSSYSE LGLQLLIDLL TLRNSSYWLV
860 870 880 890 900
RTELLETLAE IDFRLVSFLE AKAENLHRGA HHYTGLLTLQ ERVLTSVVIH
910 920 930 940 950
LLGDEDPRVR HVAAASLIRL VPKLFYKCDQ GQADPVVAVA RDQSSVYLKL
960 970 980 990 1000
LMHETQPPSH FSVSTITRIY RGYNLLPSII DVTMENNLSR VIAAVSHELI
1010 1020 1030 1040 1050
TSTTRALTFG CCEALCLLST AFPVCIWSLG WHCGVPPLSA SDECRKSCTI
1060 1070 1080 1090 1100
GMATMILTLL SSAWFPLDLS AHQDALILAG NLLAASAPKS LRSSWTSEEE
1110 1120 1130 1140 1150
ANPAATKQEE VWPALGDRAL VPMVEQLFSH LLKVINICAH VLDDVAPGPA
1160 1170 1180 1190 1200
IKAALPSLTN PPSLSPIRRK GKEKEPGEQA SVPLSPKKGS EASAASRQSD
1210 1220 1230 1240 1250
TSGPVTTSKS SSLGSFYHLP SYLKLHDVLK ATHANYKVTL DLQNSTEKFG
1260 1270 1280 1290 1300
GFLRSALDVL SQILELATLQ DIGKVCVLFF LFGLWLAHLT CILWAELDIF
1310 1320 1330 1340 1350
ISRESEAIIP NIFFFLVLLS YERYHSKQII GIPKIIQLCD GIMASGRKAV
1360 1370 1380 1390 1400
THAIPALQPI VHDLFVLRGA NKADAGKELE TQKEVVVSML LRLIQYHQVL
1410 1420 1430 1440 1450
EMFILVLQQC HKENEDKWKR LSRQIADIIL PMLAKQQMHI DSHEALGVLN
1460 1470 1480 1490 1500
TLFEILAPSS LRPVDMLLRS MFVTPNTMAS VSTVQLWISG ILAILRVLIS
1510 1520 1530 1540 1550
QSTEDIVLSR IQELTFSPYL ISCPVISRLR DGDSNSALEE HSEGKQIKTL
1560 1570 1580 1590 1600
PEETFSRFLL QLVGILLEDI VTKQLKVEMS EQQHTFYCQE LGTLLMCLIH
1610 1620 1630 1640 1650
IFKSGMFRRI TAAATRLFRS DGCGGSFYTL ESLNLRARSM ITTHPTLVLL
1660 1670 1680 1690 1700
WCQILLLVNH TDYRWWAEVQ QTPKRHSLSS TKLLSPQMSG EEEDSDLAAK
1710 1720 1730 1740 1750
LGMCNREIVR RGALILFCDY VCQNLHDSEH LTWLIVNHIQ DLISLSHEPP
1760 1770 1780 1790 1800
VQDFISAVHR NSAASGLFIQ AIQSRCENLS TPTTLKKTLQ CLEGIHLSQS
1810 1820 1830 1840 1850
GAVLTLYVDR LLCTPFRVLA RMVDILACRR VEMLLAANLQ SSMAQLPMEE
1860 1870 1880 1890 1900
LNRIQEYLQS SGLAQRHQRL YSLLDRFRLS TLQDSLSPSP PVSSHPLDGD
1910 1920 1930 1940 1950
GHVSLETVSP DKDWYIHLVK SQCWTRSDSA LLEGAELVNR IPAEDMSAFM
1960 1970 1980 1990 2000
MNSEFNISLL APCLSLGMSE ISGGQKSPLF EAAREVTLAR VSGTVQRLPA
2010 2020 2030 2040 2050
VHHVFQPHLP AEPAAYWSKL NDLFGDAALY QSLTTLARAL AQYLVVVSKL
2060 2070 2080 2090 2100
PTHLHLPPEK EKDTVKFVVA TLEALSWHLI HEQIPLSLDL QAGLDCCCLA
2110 2120 2130 2140 2150
LQLPGLWSVI SSTEFVTHAC SLIHCVHFIL EAVAVQPGEQ LLSPERRRNT
2160 2170 2180 2190 2200
PKAIREEEEV DANTQNPKYI TAACEMVAEM VESLQSVLAL GHKRNSSVPA
2210 2220 2230 2240 2250
FLTSVLRNII VSLARLPLVN SYTRVPPLVW KLGWSPKPGG EFGTAFPEIP
2260 2270 2280 2290 2300
VEFLQEKEVF KEFIYRINTL GWTSRTQFEE TWATLLGVLV TQPLVMEQEE
2310 2320 2330 2340 2350
SPPEEDTERT QINVLAVQAI TSLVLSAMTV PVAGNPAVSC LEQQPRNKPL
2360 2370 2380 2390 2400
KALDTRFGRK LSIIRGIVEQ EIQAMVSKRE NIATHHLYQA WDPVPSLSPA
2410 2420 2430 2440 2450
TTGALISHEK LLLQTNPERE LGSMSYKLGQ VSIHSVWLGN NITPLREEEW
2460 2470 2480 2490 2500
GEEEEEEADT PAPSSPPTSP VNSRKHRAGV DIHSCSQFLL ELYSRWILPS
2510 2520 2530 2540 2550
SSARRTPAIL ISEVVRSLLV VSDLFTERSQ FELMYVTLTE LRRVHPSEDE
2560 2570 2580 2590 2600
ILAQYLVPAT CKAAAVLGMD KAVAEPVSRL LESTLRSSHL PSRVGALHGI
2610 2620 2630 2640 2650
LYVLECDLLD DTAKQLIPVI SDYLLSSLKG LAHCVNTHSQ QHVLVMCATA
2660 2670 2680 2690 2700
FYLIENYPLD VGPEFSASII QMCGVMLSGS EESTPSIIYH CALRGLERLL
2710 2720 2730 2740 2750
LSEQLSRLDA ESLVKLSVDR VNVHSPHRAM AALGLMLTCM YTGKEKISPG
2760 2770 2780 2790 2800
RTSDPNPAAP DSESVIVAME RVSVLFDRIR KGFPCEARVV ARILPQFLDD
2810 2820 2830 2840 2850
FFPPQDIMNK VIGEFLSNQQ PYPQFMATVV YKVFQTLHST GQSSMVRDWV
2860 2870 2880 2890 2900
MLSLSNFTQR TPVAMAMWSL SCFFVSASTS PWVAAILPHV ISRMGKLEQV
2910 2920 2930 2940 2950
DVNLFCLVAT DFYRHQIEEE LDRRAFQSVF EMVAAPGSPY HRLLTCLRNV

HKVSTC
Length:2,956
Mass (Da):326,814
Last modified:June 20, 2018 - v2
Checksum:iBB12921C84899077
GO

Genome annotation databases

EnsembliENSCJAT00000027377; ENSCJAP00000025906; ENSCJAG00000014069

Similar proteinsi

Entry informationi

Entry nameiF6XPL5_CALJA
AccessioniPrimary (citable) accession number: F6XPL5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: July 18, 2018
This is version 30 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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