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Entry version 48 (02 Jun 2021)
Sequence version 3 (11 Dec 2019)
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Protein

Stork_head domain-containing protein

Gene

STOX2

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stork_head domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STOX2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000004310, Expressed in testis and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000005305

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni373 – 429DisorderedSequence analysisAdd BLAST57
Regioni488 – 584DisorderedSequence analysisAdd BLAST97
Regioni606 – 627DisorderedSequence analysisAdd BLAST22
Regioni671 – 717DisorderedSequence analysisAdd BLAST47
Regioni792 – 898DisorderedSequence analysisAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi386 – 410Basic residuesSequence analysisAdd BLAST25
Compositional biasi411 – 429Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi511 – 531Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi547 – 584Polar residuesSequence analysisAdd BLAST38
Compositional biasi792 – 808Polar residuesSequence analysisAdd BLAST17
Compositional biasi815 – 859Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi861 – 898Polar residuesSequence analysisAdd BLAST38

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3897, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013650_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6XNG8

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPSRKNH

Database of Orthologous Groups

More...
OrthoDBi
494782at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331863

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019391, Storkhead-box_winged-helix
IPR040126, STOX1/2

The PANTHER Classification System

More...
PANTHERi
PTHR22437, PTHR22437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10264, Stork_head, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6XNG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSNYFSWLS THLHCSDLGY QPENAFSETN MRMKTRMETE AERAEEECRD
60 70 80 90 100
VWYWSRCSGG EEAWMWPPGW TPRRKRQWTL FQTLAWQGVR ERKPLCDVSP
110 120 130 140 150
ISMSPISQSQ FIPLGEILCL AISAMNSARK PVTPEALMEH LTTCFPGVPT
160 170 180 190 200
PSQEILRHTL NMLVRERKIY PTPDGYFIVT PQTYFITPSL IRTNSKWYHL
210 220 230 240 250
DERIPDRTQC TSPQPGTITP STSGCVRDRT LPKNHCDSCH CCREDMHSMH
260 270 280 290 300
ASTLQRKAAK DCPPSLCQLP PTEKSKSTVN FSYKTETLSK PKDSEKQSKK
310 320 330 340 350
FGLKLFRLSF KKDKTKQLTN FSAQFPPEEW PLRDEETPTT IPREVEMEII
360 370 380 390 400
RRINPDLTVE NVMRHTALMK KLDEEKAQRS KTGSSAHHSG RSKKGRNHRK
410 420 430 440 450
THGKTRSHSK TRGSKGGDPS DGSHLDITAD RDYDLGDPLT RSPREGCFIV
460 470 480 490 500
EHKGDHFITH SHPNMLEPHF PMTPEWDVSG ELAKRRTEMP FPEPSRGSSH
510 520 530 540 550
SKVHRSHSHT QDRRSRNERS NKAKERSRSM DNSKGPLGAV SLGTTEDIAE
560 570 580 590 600
GCSQDDPTTP SQSYTDDSTL RPSQTVSHPR AHISSTSYKE VCIPEVISGS
610 620 630 640 650
IDAPNSCSLS EQSKPPESLP PYNELNACPT KTAMDDYFQC NTSSETVLTA
660 670 680 690 700
PSPLGKNKDD ADTLTLTDGM KKLSSSERQP PHPTREPVVH KEESPKGPGG
710 720 730 740 750
GLAAISGPAT DSLANGRLLP HHSTESISLD KIFSKDTLFK PLHSALSMNN
760 770 780 790 800
YHKPTVSLLK AHPQTSPDAL PGRCEILEQS LAASVGQAVP LSQRQQEAGG
810 820 830 840 850
NQEASFDYYN VSDDDDSEEG AHKNTEEEKN RDDVGTMQWL LEREKERDLQ
860 870 880 890
RKFEKNLTLL APKETENSNS QRATHSARLD SMDSSSITVD SGFNSPRN
Length:898
Mass (Da):100,855
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF265AB81EF8CDE5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8GAE4A0A5F8GAE4_MONDO
Stork_head domain-containing protei...
STOX2
920Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8GKB0A0A5F8GKB0_MONDO
Stork_head domain-containing protei...
STOX2
960Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000005419; ENSMODP00000005305; ENSMODG00000004310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000005305

Genome annotation databases

EnsembliENSMODT00000005419; ENSMODP00000005305; ENSMODG00000004310

Phylogenomic databases

eggNOGiKOG3897, Eukaryota
GeneTreeiENSGT00520000055589
HOGENOMiCLU_013650_0_0_1
InParanoidiF6XNG8
OMAiRPSRKNH
OrthoDBi494782at2759
TreeFamiTF331863

Gene expression databases

BgeeiENSMODG00000004310, Expressed in testis and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019391, Storkhead-box_winged-helix
IPR040126, STOX1/2
PANTHERiPTHR22437, PTHR22437, 1 hit
PfamiView protein in Pfam
PF10264, Stork_head, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XNG8_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XNG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 48 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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