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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi289Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi369Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi386Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi426Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-CFA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-CFA-174411 Polymerase switching on the C-strand of the telomere
R-CFA-174430 Telomere C-strand synthesis initiation
R-CFA-68952 DNA replication initiation
R-CFA-68962 Activation of the pre-replicative complex
R-CFA-69091 Polymerase switching
R-CFA-69166 Removal of the Flap Intermediate
R-CFA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:49102 PRIM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF6XMH3

Expressioni

Gene expression databases

BgeeiENSCAFG00000023267

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030957

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2267 Eukaryota
COG2219 LUCA
GeneTreeiENSGT00390000009790
InParanoidiF6XMH3
KOiK02685
OMAiDCHGCPY
OrthoDBiEOG091G08G7
TreeFamiTF105893

Family and domain databases

CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
InterProiView protein in InterPro
IPR016558 DNA_primase_lsu_euk
IPR007238 DNA_primase_lsu_euk/arc
PANTHERiPTHR10537 PTHR10537, 1 hit
PfamiView protein in Pfam
PF04104 DNA_primase_lrg, 1 hit
PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

Sequencei

Sequence statusi: Complete.

F6XMH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSGGMRKK LRLGGDQRKA SYPHSLQFYL EPPSENISLI EFESLAIDRV
60 70 80 90 100
KLLKAVENLG VSYVKGIEPY QSKLENEIRR LKFSFRESLE DEYEPRRKDH
110 120 130 140 150
ISHFILRLAY CQSEDLRRWF IQQEMDLLRF RFSILPKDKI RNFLKDSHLQ
160 170 180 190 200
FEAISDDEKS LREQEILASS PSLCGSKLDL DSESVYKIPF ADALDLFRGR
210 220 230 240 250
KVYLEGGFAY VPLRDIVAIV LNEFRAKLSK ALALTARSLP AVQSDERLQP
260 270 280 290 300
LLNHLSHSYT GQDYSIQKNA GKISLDQIDS LSTKSFPPCM RQLHKALREN
310 320 330 340 350
HHLRHGGRMQ YGLFLKGIGL TLEQALQFWK QEFIRGKMDP DKFDKGYAYN
360 370 380 390 400
IRHSFGKEGK RTDYTPFSCL KIILTNPPGQ GDYHGCPFRH SDPELLKQKL
410 420 430 440 450
QSYKISPAGI NQILDLVKGT HYQVACQKYF EMIHNVDDCG FSLNHPNQFF
460 470 480 490 500
FESQRILNGS KDIRKESIQP ETPQPKPSVQ KTKDASSALA YLNSSLEMDM

EGLEDYFSE
Length:509
Mass (Da):58,756
Last modified:October 31, 2012 - v1
Checksum:i9EE71BFF66699586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008410 Genomic DNA No translation available.
RefSeqiXP_532185.2, XM_532185.5

Genome annotation databases

EnsembliENSCAFT00000035673; ENSCAFP00000030957; ENSCAFG00000023267
GeneIDi474950
KEGGicfa:474950

Similar proteinsi

Entry informationi

Entry nameiF6XMH3_CANLF
AccessioniPrimary (citable) accession number: F6XMH3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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