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Entry version 64 (12 Aug 2020)
Sequence version 2 (04 Feb 2015)
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Protein
Submitted name:

Ciliary rootlet coiled-coil, rootletin family member 2

Gene

Crocc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ciliary rootlet coiled-coil, rootletin family member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crocc2Imported
Synonyms:E030010N08RikImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045962, Crocc2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6XLV1

PRoteomics IDEntifications database

More...
PRIDEi
F6XLV1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F6XLV1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000084989, Expressed in telencephalon and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000120588

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
F6XLV1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
F6XLV1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni39 – 92DisorderedSequence analysisAdd BLAST54
Regioni396 – 423DisorderedSequence analysisAdd BLAST28
Regioni1168 – 1213DisorderedSequence analysisAdd BLAST46
Regioni1338 – 1383DisorderedSequence analysisAdd BLAST46
Regioni1506 – 1551DisorderedSequence analysisAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili124 – 144Sequence analysisAdd BLAST21
Coiled coili170 – 190Sequence analysisAdd BLAST21
Coiled coili279 – 299Sequence analysisAdd BLAST21
Coiled coili325 – 345Sequence analysisAdd BLAST21
Coiled coili353 – 373Sequence analysisAdd BLAST21
Coiled coili426 – 467Sequence analysisAdd BLAST42
Coiled coili472 – 537Sequence analysisAdd BLAST66
Coiled coili549 – 593Sequence analysisAdd BLAST45
Coiled coili615 – 635Sequence analysisAdd BLAST21
Coiled coili657 – 691Sequence analysisAdd BLAST35
Coiled coili706 – 859Sequence analysisAdd BLAST154
Coiled coili864 – 920Sequence analysisAdd BLAST57
Coiled coili932 – 966Sequence analysisAdd BLAST35
Coiled coili975 – 1013Sequence analysisAdd BLAST39
Coiled coili1214 – 1234Sequence analysisAdd BLAST21
Coiled coili1281 – 1315Sequence analysisAdd BLAST35
Coiled coili1412 – 1481Sequence analysisAdd BLAST70
Coiled coili1486 – 1506Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi405 – 423PolarSequence analysisAdd BLAST19
Compositional biasi1168 – 1196PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1338 – 1371PolarSequence analysisAdd BLAST34
Compositional biasi1532 – 1551PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQV3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162689

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000920_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6XLV1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRWPSPT

Database of Orthologous Groups

More...
OrthoDBi
76868at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6XLV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTSSNPDD GDTTEQSQLG LDTVIKKLED TILSPMARRE DRALTVRGEG
60 70 80 90 100
QRASPTPVPA RIREIVSSSL GEEPLSGLRE PPATTSHARE ESELLQEELT
110 120 130 140 150
RLEDLLAQAD AEREELASRC HMVSQRLQAR LDTTEARLRK SELEHSMDLE
160 170 180 190 200
EALSRLEASQ QRSMGLSQVN TLLRQQLEHM QKANDTLARE LTRATHSLVH
210 220 230 240 250
LQRKLELQES QRLSLRQPRD ILPLWRQAKA LQTHLAELRA STERGLTDVQ
260 270 280 290 300
ADMTRTAQRL HMACLNLDSH LRLTASSMTS DLEQRLREQA REMLQLQGQW
310 320 330 340 350
AAEKVALQAR LSEQTLLVEK LSVQKEQGER AILTLKSDIQ RLKSRRSGGQ
360 370 380 390 400
LAVDELRDEV ESLHHVLASI KEVAQSDAMC PELAWSSSIE VREAQARLRS
410 420 430 440 450
PPRSVSPHQR MSPARTSSPT SLHPALQAVQ AAIERRQQRE QELRLRLESS
460 470 480 490 500
QEEAAGLREQ LSGYRQELRT SQRLLQDRAQ EHEDLLGQLE AQRQEAQLSQ
510 520 530 540 550
ASVHLLEREK EALETTMEEL RAKADIREAE TQKLEVTNAE LRRSLLLRAE
560 570 580 590 600
QKAELAQQSE RSLRELEASQ GRVEQLEEKV SGLRKELATS REALSSMQLQ
610 620 630 640 650
RDILETEKES LHGALAQAES GNADLELLVT RLKAEGMEQQ DSLAKMAALL
660 670 680 690 700
EGLSQDKGTL NHLALQLEQE RDQLREQQKM LQQEQAGMRE QLTQTGQQLG
710 720 730 740 750
LIRAERRSLK ETCGHLEQKQ DHLEKQVVLL GQENAQLREQ VGQVTNKKQA
760 770 780 790 800
LEKQLAQSLQ DQEAQMDILQ EALHEKNTLS EERAQLLAKQ EALERHSELV
810 820 830 840 850
TKEAADLRAE RNSLENSLFE AQRLTTQLQT QQEQLEGKAE AAQLARRALQ
860 870 880 890 900
VEIERLKSDW EVRETKLQLH LGQLQQQAAQ QEQEAQLALE RQELAHTEDL
910 920 930 940 950
ARLHREKDTL SLSLAEEKEA AARWMEQQKE LLTRSAADRE ALQGEIQNLK
960 970 980 990 1000
QERDESLLQL EHEMQQALSL KDAEKSLLSK ELSGAHRELE RARQEAQNQQ
1010 1020 1030 1040 1050
VQAEATVTTM TKELRTLQVQ FEEAISTHQR EADTLREKLR EIAAERSSVR
1060 1070 1080 1090 1100
REAEELQAQL NVAHERLAEL RQELQASEES REGLQREALG ARRALEDEVQ
1110 1120 1130 1140 1150
EKDVLQHSNT ELRASIHRAE QEKASLKRSK EEQEQKLLLL QEAQVAAQKE
1160 1170 1180 1190 1200
AYELRTRLQE LERAQRDTRR KLQERHRQVR TLEAENQRKR QEVSDLQAQV
1210 1220 1230 1240 1250
SRDAQHRQKN LQESLELQRQ VAEAQAAHDG VQKEVLGLRQ KLAEVEASGE
1260 1270 1280 1290 1300
TRAKQLEGHL CESQRAEQTL QAELCRITRK LQEASNQADS LQRSLDNACS
1310 1320 1330 1340 1350
RVHVLEQELA KAEGARCNAE AQLGRLWSTL CSGLGQSRNL LASPKRPHSP
1360 1370 1380 1390 1400
TTGSSQTRPG RQRTSPPTRS YSPARWPSPV PVDPKSEVID VAFVRDALRD
1410 1420 1430 1440 1450
LVQGLLEAQQ ERDNSGIQVA NLSSQLSEAE RERLRLQSRV EQLQRDLADA
1460 1470 1480 1490 1500
EEGQRRAESA LQSAQAARAL QKEALQRLET EHLASARAAG QERRRLQEQV
1510 1520 1530 1540 1550
DTLRQALEES SRPSQSLADK GRLLEQPLQQ VLPHSRRDRA ERRALREQTT
1560 1570 1580 1590 1600
SLRTERARLQ GELAALRTRL IQTEQETLKK EEDRAMLGAK KELLLQSLSH
1610 1620 1630
LHQEVDGALR QSQQLQVASL KKRLDKEVWQ RQQQAHSD
Length:1,638
Mass (Da):186,631
Last modified:February 4, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2477189C6D423D93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC103673 Genomic DNA No translation available.
AC124669 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001297357.1, NM_001310428.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000138595; ENSMUSP00000120588; ENSMUSG00000084989

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
381284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:381284

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103673 Genomic DNA No translation available.
AC124669 Genomic DNA No translation available.
RefSeqiNP_001297357.1, NM_001310428.1

3D structure databases

SMRiF6XLV1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120588

PTM databases

PhosphoSitePlusiF6XLV1

Proteomic databases

PaxDbiF6XLV1
PRIDEiF6XLV1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62332, 3 antibodies

Genome annotation databases

EnsembliENSMUST00000138595; ENSMUSP00000120588; ENSMUSG00000084989
GeneIDi381284
KEGGimmu:381284

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728763
MGIiMGI:3045962, Crocc2

Phylogenomic databases

eggNOGiENOG502QQV3, Eukaryota
GeneTreeiENSGT00940000162689
HOGENOMiCLU_000920_1_0_1
InParanoidiF6XLV1
OMAiLRWPSPT
OrthoDBi76868at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
381284, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Crocc2, mouse
RNActiF6XLV1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000084989, Expressed in telencephalon and 32 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6XLV1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6XLV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: February 4, 2015
Last modified: August 12, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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