ID F6XJF9_HORSE Unreviewed; 2489 AA. AC F6XJF9; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 2. DT 08-MAY-2019, entry version 46. DE SubName: Full=Translocated promoter region, nuclear basket protein {ECO:0000313|Ensembl:ENSECAP00000019021}; GN Name=TPR {ECO:0000313|Ensembl:ENSECAP00000019021, GN ECO:0000313|VGNC:VGNC:50899}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019021, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000019021, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019021, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000019021} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019021}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PRIDE; F6XJF9; -. DR Ensembl; ENSECAT00000022989; ENSECAP00000019021; ENSECAG00000020724. DR VGNC; VGNC:50899; TPR. DR eggNOG; KOG4674; Eukaryota. DR eggNOG; ENOG410XSA1; LUCA. DR GeneTree; ENSGT00730000111014; -. DR Proteomes; UP000002281; Chromosome 5. DR Bgee; ENSECAG00000020724; Expressed in 3 organ(s), highest expression level in prefrontal cortex. DR ExpressionAtlas; F6XJF9; baseline. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:Ensembl. DR GO; GO:0019898; C:extrinsic component of membrane; IEA:Ensembl. DR GO; GO:0000776; C:kinetochore; IEA:Ensembl. DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl. DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl. DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl. DR GO; GO:0034399; C:nuclear periphery; IEA:Ensembl. DR GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl. DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl. DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl. DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl. DR GO; GO:0051019; F:mitogen-activated protein kinase binding; IEA:Ensembl. DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:Ensembl. DR GO; GO:0015631; F:tubulin binding; IEA:Ensembl. DR GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl. DR GO; GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Ensembl. DR GO; GO:0031990; P:mRNA export from nucleus in response to heat stress; IEA:Ensembl. DR GO; GO:0046832; P:negative regulation of RNA export from nucleus; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045947; P:negative regulation of translational initiation; IEA:Ensembl. DR GO; GO:0006999; P:nuclear pore organization; IEA:Ensembl. DR GO; GO:0031453; P:positive regulation of heterochromatin assembly; IEA:Ensembl. DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl. DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl. DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl. DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:Ensembl. DR GO; GO:0070849; P:response to epidermal growth factor; IEA:Ensembl. DR GO; GO:0006404; P:RNA import into nucleus; IEA:Ensembl. DR InterPro; IPR012929; TPR/MLP1. DR Pfam; PF07926; TPR_MLP1_2; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 1165 1292 TPR_MLP1_2. {ECO:0000259|Pfam:PF07926}. FT COILED 155 175 {ECO:0000256|SAM:Coils}. FT COILED 187 298 {ECO:0000256|SAM:Coils}. FT COILED 345 407 {ECO:0000256|SAM:Coils}. FT COILED 447 492 {ECO:0000256|SAM:Coils}. FT COILED 553 639 {ECO:0000256|SAM:Coils}. FT COILED 669 696 {ECO:0000256|SAM:Coils}. FT COILED 702 729 {ECO:0000256|SAM:Coils}. FT COILED 791 878 {ECO:0000256|SAM:Coils}. FT COILED 893 927 {ECO:0000256|SAM:Coils}. FT COILED 953 994 {ECO:0000256|SAM:Coils}. FT COILED 1013 1040 {ECO:0000256|SAM:Coils}. FT COILED 1060 1108 {ECO:0000256|SAM:Coils}. FT COILED 1123 1197 {ECO:0000256|SAM:Coils}. FT COILED 1222 1242 {ECO:0000256|SAM:Coils}. FT COILED 1275 1295 {ECO:0000256|SAM:Coils}. FT COILED 1347 1374 {ECO:0000256|SAM:Coils}. FT COILED 1395 1429 {ECO:0000256|SAM:Coils}. FT COILED 1437 1471 {ECO:0000256|SAM:Coils}. FT COILED 1480 1542 {ECO:0000256|SAM:Coils}. FT COILED 1595 1678 {ECO:0000256|SAM:Coils}. FT COILED 1690 1724 {ECO:0000256|SAM:Coils}. FT COILED 1729 1756 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 2489 AA; 280090 MW; F04DFDD5593FC594 CRC64; LTSTIWRHLA DSDHAAGRGE PGGGEKGVSG MGGEELGSQK RLRKILRFPE AASELGFPGC TAASSCAPGL DFPGSRRGSL RRAGAREPVS EATEAAAQAS GSSWSSPFFS VSAPSAAAAA APGPSDMAAV LQQVLERAEL NKLPKSVQNK LEKFLADQQS EIDGLKGRHE KFKVESEQQY FEIEKRLSHS QERLVNETRE CQNLRLELEK LNNQLKALTE KNKELEVAQD RNIAIQSQFT RTKEELEAEK RDLIRTNERL SQELEYLTED VKRLNEKLKE SNATKGDLQL KLDELQASDV SVKYREKRLE QEKELLHNQN TWLNTELKTK TDELLALGRE KGNEILELKC NLENKKEEVS RMEEQMNGLK TSNENLQKHV EDLLTKLKEA KEQQASMEEK FHNELNAHIK LSNLYKSAAD DSEAKSNELT RAVDELHKLL KEAGEANKAI QDHLLEVEKS KEQMEKEMLE KIGKLEKELE NANDLLSATK RKGAILSEEE LAAMSPTAAA VAKIVKPGMK LTELYNAYVE TQDQLLLEKL ENKRINKYLD EIVKEVEAKA PILKRQREEY ERAQKAVASL SVKLEQAMKE IQRLQEDTDK ANKHSSVLER DNQRMEIQIK DLSQQIRVLL MELEEARGNH VIRDEEVSSA DISSSSEVIS QHLVSYRNIE ELQQQNQRLL VALRELGETR EREEQETTSS KITELQLKLE NALTELEQLR ESRQHQMQLV DSIVRQRDMY RILLSQITGV NIPLQASSLD DISLVSTPKR SSTSQTVSTP APVPVIESAE AIEAKAALKQ LQEIFENYKK EKADNEKIQN EQLEKFQEQV TDLRSQNTKI STQLDFASKR YEMLQDNVEG YRREITSLHE RNQKLTATTQ KQEQIINTMT QDLRGASEKL AVAEVRADNL KKEKEMLKLS EVRLSQQRES LLAEQRGQNL LLTNLQTIQG ILERSETETK QRLSNQIEKL ENEISHLKKK LENEVEQRHT LTRNLDVQLL DTKRQLDTET NLHLNTKELL KNAQKEIATL KQHLSNMEVQ LASQSSQRSG KGQPNSKEDV DDLLSQLRQT EEQVNDLKER LKTSTSNVEQ YRAMVTSLEE SLNKEKQVTE EVRKNIEVRL KESAEFQTQL EKKLMEVEKE KQELQDDKRK AIESMEQQLS ELKKTLTNVQ NEVQEALQRA STALSNEQQA RRDCQEQAKI AVEAQNKYER ELMLHAADVE ALQAAKEQVS KMASVRQHLE ETTQKAESQL LECKASWEER ERMLKDEVSK CVSRCEDLEK QNRLLHDQIE KLSDKVVASM KEGVQGPLNI SLSEEGKSQE QILEILRFIR REKEIAETRF EVAQVESLRY RQRVELLERE LQELQDSLNV EREKVQVTAK TMAQHEELMK KTETMNVVME TNKMLREEKE RLEQDLQQMQ AKVRKLELDI LPLQEANAEL SEKSGMLQAE KKLLEEDVKR WKARNQHLVS QQKDPDTEEY RKLLSEKEVH TKRIQQLTEE IGRLKAEIAR SNASLTNNQN LIQSLKEDLN KVRTEKESIQ KDLDAKIIDI QEKVKTITQV KKIGRRYKTQ YEELKAQQDK AMETSAQSSG DHQEQHVSVQ EMQELKETLN QAETKSKSLE NQVENLQKTL SEKETEARNL QEQTVQLQSE LSRLRQDLQD RTTQEEQLRQ QITEKEEKTR KAIVAAKSKI AHLAGVKDQL TKENEELKQR NGALDQQKDE LDVRMTALKS QYEGRISRLE RELREHQERH LEQRDEPQEP TNKVPEQQRQ ITLKTTPASG ERGIASTSDP PTANIKPTPV VSTPSKVTAA AMAGNKSTPR ASIRPMVTPA TVTNPTTTPT ATVMPTTQVE SQEAMQSEGP VEHVPVFGST SGSVRSTSPN VQPSIPQPIL TVQQQTQATA FVQPTQQSHP QIEPANQELS PNIVEVVQSS PVERPSTSTA VFGTVSATPS SSLPKRTREE EEDSTIEASD QVSDDTVEMP LPKKLKSVTP VGTEEEVMAE ESTDGEVETQ VYNQDSQDSI GEGVTQGDYT PMEDSEETSQ SLQIDLGPLQ SDQQTTTSSQ DGQGKGDDVI VIDSDDEEDD DDDNDGEHED YEEDEEEDDD DEDDTGMGDE GEDSNEGTGS ADGNDGYEAD DAEGGDGTDP GTETEESMGG GESNQRAADS QNSGEGNTGT AESSFSQEIA REQQPSSASE RQTPRAPQSP RRPPHPLPPR LTIHAPPQEL GPPVQRIQMT RRQSVGRGLQ LTPGIGGMQQ HFFDDEDRTV PSTPTLVVPH RTDGFAEAIH SPQVAGVPRF RFGPPEDMPQ TSSSHSDLGQ LASQGGLGMY ETPLFLAHEE ESGGRSVPTT PLQVAAPVTV FTESTTSDAS EHASQSVPMV TTSTGTLSTT NETATGDDGD EVFVEAESEG ISSEAGLEID SQQEEEPVQA SDESDLPSTS QDPPSSSSVD TSSSQPKPFR RVRLQTTLRQ GVRGRQFNRQ RGVSHAMGGR GGINRGNIN //