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Protein
Submitted name:

Uncharacterized protein

Gene

HCN3

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HCN3Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei101 – 125HelicalSequence analysisAdd BLAST25
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Transmembranei332 – 357HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMODG00000017060 Expressed in 7 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000021288

Structurei

3D structure databases

ProteinModelPortaliF6XHS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini435 – 541Cyclic nucleotide-bindingInterPro annotationAdd BLAST107

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140801
InParanoidiF6XHS5
KOiK04956
OMAiVMEQHLV
OrthoDBiEOG091G0JQU
TreeFamiTF318250

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

F6XHS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTKQRPAAA AAGAGDEGTP GLETASPPAP SPATAAPGPS PAPGPESGPG
60 70 80 90 100
PMRRQLGALL QPAVNKFSLR VFGSHKAVEI EQERVKSAGA WIIHPYSDFR
110 120 130 140 150
FYWDLIMLLL MVGNLIVLPV GITFFKEENS PPWIVFNVLS DTFFLLDLVL
160 170 180 190 200
NFRTGIVVEE GAEILLAPQA IRTRYLRTWF LVDLISSIPV DYIFLVVELE
210 220 230 240 250
PRLDAEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD
260 270 280 290 300
LASAVVRIFN LIGMMLLLCH WDGCLQFLVP MLQDFPPDCW VSINHMVNHS
310 320 330 340 350
WGRQYSHALF KAMSHMLCIG YGQQAPQGMP DVWLTMLSMI VGATCYAMFI
360 370 380 390 400
GHATALIQSL DSSRRQYQEK YKQVEQYMSF HKLPADTRQR IHEYYEHRYQ
410 420 430 440 450
GKMFDEESIL GELSEPLREE IINFTCRGLV AHMPLFAHAD PSFVTAVLTK
460 470 480 490 500
LRFEVFQPGD LVVREGSVGR KMYFIQHGLL SVLTRGARDT RLTDGSYFGE
510 520 530 540 550
ICLLTRGRRT ASVRADTYCR LYSLSVDHFN AVLEEFPMMR RAFETVAMDR
560 570 580 590 600
LHRIGKKNSL LQRKRSEPSP GSGGSGVMEQ HLVQHDRDMA RGVRGLAPGT
610 620 630 640 650
GARLSGKPVL WEPLVHAPLQ AAAVTSNVAI ALTHHRAPLP LSPDSPAALL
660 670 680 690 700
ARSARRSAGS PASPLVPARG LPLLARGPWA STSRLPAPAA RTLHASLSRA
710 720 730 740 750
GRSQVSLLGP PPGGGGRRLG PRGRPLSASQ PSLPHRAAGE GSPGRKGSGG
760 770 780
ERLPASGLLT RLPGTAQPLR PPASDPGTSR GPQLPANM
Length:788
Mass (Da):86,881
Last modified:July 27, 2011 - v1
Checksum:i1D11EBBFB121E1DF
GO

Sequence databases

RefSeqiXP_016285892.1, XM_016430406.1

Genome annotation databases

EnsembliENSMODT00000021662; ENSMODP00000021288; ENSMODG00000017060
GeneIDi100016954
KEGGimdo:100016954

Cross-referencesi

Sequence databases

RefSeqiXP_016285892.1, XM_016430406.1

3D structure databases

ProteinModelPortaliF6XHS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000021288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMODT00000021662; ENSMODP00000021288; ENSMODG00000017060
GeneIDi100016954
KEGGimdo:100016954

Organism-specific databases

CTDi57657

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140801
InParanoidiF6XHS5
KOiK04956
OMAiVMEQHLV
OrthoDBiEOG091G0JQU
TreeFamiTF318250

Gene expression databases

BgeeiENSMODG00000017060 Expressed in 7 organ(s), highest expression level in cerebellum

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6XHS5_MONDO
AccessioniPrimary (citable) accession number: F6XHS5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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