UniProtKB - F6XHE4 (F6XHE4_CIOIN)
Protein
Submitted name:
Uncharacterized protein
Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 198 | Succinate; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 202 | SuccinateCombined sources | 1 |
GO - Molecular functioni
- ion channel activity Source: InterPro
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: GO_Central
- protein tyrosine phosphatase activity Source: GO_Central
GO - Biological processi
- cell motility Source: GO_Central
- dephosphorylation Source: GO_Central
- negative regulation of cell population proliferation Source: GO_Central
- phosphatidylinositol 3-kinase signaling Source: GO_Central
- phosphatidylinositol dephosphorylation Source: GO_Central
- protein dephosphorylation Source: GO_Central
- regulation of protein kinase B signaling Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Organismi | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported |
Taxonomic identifieri | 7719 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Tunicata › Ascidiacea › Phlebobranchia › Cionidae › Ciona |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell projection Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 110 – 129 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 149 – 166 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 178 – 197 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 247 – 423 | Phosphatase tensin-typeInterPro annotationAdd BLAST | 177 | |
Domaini | 425 – 567 | C2 tensin-typeInterPro annotationAdd BLAST | 143 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 63 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 44 – 63 | PolyampholyteSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154335 |
HOGENOMi | CLU_020105_3_0_1 |
InParanoidi | F6XHE4 |
OMAi | NCRIFHD |
TreeFami | TF354329 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029021, Prot-tyrosine_phosphatase-like IPR014020, Tensin_C2-dom IPR029023, Tensin_phosphatase IPR016130, Tyr_Pase_AS IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF10409, PTEN_C2, 1 hit |
SMARTi | View protein in SMART SM01326, PTEN_C2, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51182, C2_TENSIN, 1 hit PS51181, PPASE_TENSIN, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
F6XHE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGFDGSDFS PPADLVGVDG AVMRNVVDVT INGDVTAPPK AAPRKSESVK
60 70 80 90 100
KVHWNDVDQG PSEKERIDIP EISGLWWGEN EHGVDDGRME IPTTGVGRVQ
110 120 130 140 150
FRVRAVIDHL GMRVFGVFLI FLDIILMIID LSLPGKSESS QSFYDGMALA
160 170 180 190 200
LSCYFMLDLG LRIFAYGPKN FFTNPWEVAD GLIIVVTFVV TIFYTVLDEY
210 220 230 240 250
VQETGADGLG RLVVLARLLR VVRLARIFYS HQQMKASSRR TISQNKRRYR
260 270 280 290 300
KDGFDLDLTY VTDHVIAMSF PSSGRQSLFR NPIGEVSRFF KTKHPDKFRI
310 320 330 340 350
YNLCSERGYD ETKFDNHVYR VMIDDHNVPT LVDLLKFIDD AKVWMTSDPD
360 370 380 390 400
HVIAIHCKGG KGRTGTLVSS WLLEDGKFDT AKEALEYFGS RRTDFEVGDV
410 420 430 440 450
FQGVETASQI RYVGYFEKIK KNYGGQLPPM KKLKVTGVTI TAIQGVGRGN
460 470 480 490 500
GSDLSMQIVS ERQEVLLCKF AEGYNCALQY DATDDCVTCE VKNCPMLAGD
510 520 530 540 550
IKVRFMSTSK SLPRGYDNCP FYFWFNTSLV EGDHVTLKRE EIDNPHKKKT
560 570
WKIYRDNFTV KLTFSDAEDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EAAA01001449 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSCINT00000022172; ENSCINP00000021926; ENSCING00000011484 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EAAA01001449 Genomic DNA No translation available. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4G7V | X-ray | 2.50 | S | 83-254 | [»] | |
4G80 | X-ray | 3.58 | I/J/S/T | 100-238 | [»] | |
SMRi | F6XHE4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protocols and materials databases
ABCDi | F6XHE4, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSCINT00000022172; ENSCINP00000021926; ENSCING00000011484 |
Phylogenomic databases
GeneTreei | ENSGT00940000154335 |
HOGENOMi | CLU_020105_3_0_1 |
InParanoidi | F6XHE4 |
OMAi | NCRIFHD |
TreeFami | TF354329 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029021, Prot-tyrosine_phosphatase-like IPR014020, Tensin_C2-dom IPR029023, Tensin_phosphatase IPR016130, Tyr_Pase_AS IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF10409, PTEN_C2, 1 hit |
SMARTi | View protein in SMART SM01326, PTEN_C2, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51182, C2_TENSIN, 1 hit PS51181, PPASE_TENSIN, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6XHE4_CIOIN | |
Accessioni | F6XHE4Primary (citable) accession number: F6XHE4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | April 7, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |