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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
N/A
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd), Glucose-6-phosphate 1-dehydrogenase (g6pd), Glucose-6-phosphate 1-dehydrogenase
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei205SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-5628897 TP53 Regulates Metabolic Genes
R-XTR-71336 Pentose phosphate pathway
UniPathwayi
UPA00115;UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

PTM / Processingi

Proteomic databases

PaxDbiF6XH10

Expressioni

Gene expression databases

BgeeiENSXETG00000033535 Expressed in 11 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058835

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 210G6PD_NInterPro annotationAdd BLAST176
Domaini212 – 499G6PD_CInterPro annotationAdd BLAST288

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0563 Eukaryota
COG0364 LUCA
GeneTreeiENSGT00530000063435
InParanoidiF6XH10
OMAiVEICVYE
OrthoDBiEOG091G06FN
TreeFamiTF300584

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

F6XH10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AHEQVHLSRS EVCGMMREEL FSEQEFHQSQ THIFIVVGAS GDLAKKKIYP
60 70 80 90 100
TLWWLYNDGL LPEDTYIVGF ARSKLTVQDI RKQSEQYFKV STEDAEKLDS
110 120 130 140 150
FFKRNSYISG QYSDAASFQN LNQHLNSLPN GAKANRLFYL AVPPSVYHDV
160 170 180 190 200
TRNIKETCMS SVGWNRVIVE KPFGKDLESS NRLSEHISAL YKENQIYRID
210 220 230 240 250
HYLGKEMVQN LMILRFGNRI FSPLWSRDHI SAVVLTFKEP FGTQGRGGYF
260 270 280 290 300
DEFGIIRDVM QNHLLQMMCL MAMEKPVSTS SDDVRDEKVK VLKSVSPLTL
310 320 330 340 350
DNLVVGQYVG NAEGQGEAQL GYLDDRTVPK GSLTPTFATA VLYVQNERWD
360 370 380 390 400
GVPFIMRCGK ALNERKAEAR LQFRDVPGDI FQGHCKRNEL VIRVQPNEAV
410 420 430 440 450
YTKMMTKKPG MFFNPEESEL DLTYGNRYKG YKSSNEQRWV GLDSWHRLIF
460 470 480 490 500
LHRHRTPYPS CTTILRDLRV TDPSVMTFIR FSRGPAESDE LMQKVGFHYA
510
GTYKWVNPNK L
Length:511
Mass (Da):58,861
Last modified:July 27, 2011 - v1
Checksum:i4D9D21F65A854FE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01094731 Genomic DNA No translation available.
AAMC01094732 Genomic DNA No translation available.
AAMC01094733 Genomic DNA No translation available.
AAMC01094734 Genomic DNA No translation available.
AAMC01094735 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000063354; ENSXETP00000058835; ENSXETG00000033535

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01094731 Genomic DNA No translation available.
AAMC01094732 Genomic DNA No translation available.
AAMC01094733 Genomic DNA No translation available.
AAMC01094734 Genomic DNA No translation available.
AAMC01094735 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058835

Proteomic databases

PaxDbiF6XH10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000063354; ENSXETP00000058835; ENSXETG00000033535

Phylogenomic databases

eggNOGiKOG0563 Eukaryota
COG0364 LUCA
GeneTreeiENSGT00530000063435
InParanoidiF6XH10
OMAiVEICVYE
OrthoDBiEOG091G06FN
TreeFamiTF300584

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00408

ReactomeiR-XTR-5628897 TP53 Regulates Metabolic Genes
R-XTR-71336 Pentose phosphate pathway

Gene expression databases

BgeeiENSXETG00000033535 Expressed in 11 organ(s), highest expression level in embryo

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6XH10_XENTR
AccessioniPrimary (citable) accession number: F6XH10
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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