UniProtKB - F6XEW8 (F6XEW8_HORSE)
Protein
RNA-binding protein 8A
Gene
RBM8A
Organism
Equus caballus (Horse)
Status
Functioni
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.UniRule annotation
GO - Molecular functioni
- mRNA binding Source: GO_Central
GO - Biological processi
- mRNA splicing, via spliceosome Source: Ensembl
- mRNA transport Source: UniProtKB-KW
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: GO_Central
- regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | mRNA processing, mRNA splicing, mRNA transportUniRule annotation, Nonsense-mediated mRNA decayARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 8AUniRule annotation |
Gene namesi | Name:RBM8AImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:22252, RBM8A |
Subcellular locationi
Nucleus
- Nucleus speckle UniRule annotationARBA annotation
- Nucleus UniRule annotation
Other locations
- Cytoplasm UniRule annotationARBA annotation
Nucleus
- catalytic step 2 spliceosome Source: Ensembl
- exon-exon junction complex Source: GO_Central
- nuclear speck Source: UniProtKB-SubCell
- U2-type catalytic step 1 spliceosome Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation, SpliceosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000022024, Expressed in embryo and 23 other tissues |
Interactioni
Subunit structurei
Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 151 | RRMInterPro annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 151 – 174 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 29 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 36 – 65 | PolyampholyteSequence analysisAdd BLAST | 30 | |
Compositional biasi | 156 – 174 | BasicSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00730000111185 |
HOGENOMi | CLU_012062_18_3_1 |
InParanoidi | F6XEW8 |
OMAi | RDDVGHY |
OrthoDBi | 1234149at2759 |
TreeFami | TF314933 |
Family and domain databases
CDDi | cd12324, RRM_RBM8, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR008111, RNA-bd_8 IPR000504, RRM_dom IPR033744, RRM_RBM8 |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
PRINTSi | PR01738, RNABINDINGM8 |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
F6XEW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM
60 70 80 90 100
REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK
110 120 130 140 150
NIHLNLDRRT GYLKGYTLVE YETYKEAQAA MEGLNGQDLM GQPISVDWCF
160 170
VRGPPKGKRR GGRRRSRSPD RRRR
Sequence databases
RefSeqi | NP_001157445.1, NM_001163973.1 |
Genome annotation databases
Ensembli | ENSECAT00000023591; ENSECAP00000019548; ENSECAG00000022024 |
GeneIDi | 100034052 |
KEGGi | ecb:100034052 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001157445.1, NM_001163973.1 |
3D structure databases
SMRi | F6XEW8 |
ModBasei | Search... |
Proteomic databases
PaxDbi | F6XEW8 |
PRIDEi | F6XEW8 |
Genome annotation databases
Ensembli | ENSECAT00000023591; ENSECAP00000019548; ENSECAG00000022024 |
GeneIDi | 100034052 |
KEGGi | ecb:100034052 |
Organism-specific databases
CTDi | 9939 |
VGNCi | VGNC:22252, RBM8A |
Phylogenomic databases
GeneTreei | ENSGT00730000111185 |
HOGENOMi | CLU_012062_18_3_1 |
InParanoidi | F6XEW8 |
OMAi | RDDVGHY |
OrthoDBi | 1234149at2759 |
TreeFami | TF314933 |
Gene expression databases
Bgeei | ENSECAG00000022024, Expressed in embryo and 23 other tissues |
Family and domain databases
CDDi | cd12324, RRM_RBM8, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR008111, RNA-bd_8 IPR000504, RRM_dom IPR033744, RRM_RBM8 |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
PRINTSi | PR01738, RNABINDINGM8 |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6XEW8_HORSE | |
Accessioni | F6XEW8Primary (citable) accession number: F6XEW8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |