UniProtKB - F6XEI8 (F6XEI8_HORSE)
Protein
Submitted name:
RAR related orphan receptor B
Gene
RORB
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- melatonin receptor activity Source: GO_Central
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: RAR related orphan receptor BImported |
Gene namesi | Name:RORBImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:22504, RORB |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000024312, Expressed in brainstem and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 82 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 211 – 449 | NR LBDInterPro annotationAdd BLAST | 239 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 90 – 110 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157708 |
HOGENOMi | CLU_007368_2_0_1 |
InParanoidi | F6XEI8 |
OMAi | RECVHAR |
OrthoDBi | 583704at2759 |
TreeFami | TF319910 |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6XEI8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR
60 70 80 90 100
NCLIDRTNRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH
110 120 130 140 150
QQRLQEQRQQ QGGEAEALAR VYSSSISNGL SNLNNEASGT YANGHVIDLP
160 170 180 190 200
KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ EPIYDLTSVP NLFTYSSFNN
210 220 230 240 250
GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELRQLAWQ THTYEEIKAY
260 270 280 290 300
QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL
310 320 330 340 350
EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC
360 370 380 390 400
SLQLTEEEIA LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH
410 420 430 440 450
LDDETLAKLI AKIPTITAVC NLHGEKLQVF KQSHPDIVNT LFPPLYKELF
NPDCATVCK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2ILW7 | A0A3Q2ILW7_HORSE | RAR related orphan receptor B | RORB | 470 | Annotation score: |
Sequence databases
RefSeqi | XP_014590898.1, XM_014735412.1 |
Genome annotation databases
Ensembli | ENSECAT00000026225; ENSECAP00000021862; ENSECAG00000024312 |
GeneIDi | 100049831 |
KEGGi | ecb:100049831 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_014590898.1, XM_014735412.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6XEI8 |
Genome annotation databases
Ensembli | ENSECAT00000026225; ENSECAP00000021862; ENSECAG00000024312 |
GeneIDi | 100049831 |
KEGGi | ecb:100049831 |
Organism-specific databases
CTDi | 6096 |
VGNCi | VGNC:22504, RORB |
Phylogenomic databases
GeneTreei | ENSGT00940000157708 |
HOGENOMi | CLU_007368_2_0_1 |
InParanoidi | F6XEI8 |
OMAi | RECVHAR |
OrthoDBi | 583704at2759 |
TreeFami | TF319910 |
Gene expression databases
Bgeei | ENSECAG00000024312, Expressed in brainstem and 14 other tissues |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6XEI8_HORSE | |
Accessioni | F6XEI8Primary (citable) accession number: F6XEI8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |