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Entry version 51 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

UDP-glucose glycoprotein glucosyltransferase 1

Gene

UGGT1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
UDP-glucose glycoprotein glucosyltransferase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGGT1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:24776 UGGT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6X5P8

PRoteomics IDEntifications database

More...
PRIDEi
F6X5P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021191 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 236Thioredoxin_12InterPro annotationAdd BLAST180
Domaini312 – 441Thioredoxin_13InterPro annotationAdd BLAST130
Domaini451 – 699Thioredoxin_14InterPro annotationAdd BLAST249
Domaini726 – 947Thioredoxin_15InterPro annotationAdd BLAST222
Domaini1249 – 1516Glyco_transf_24InterPro annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1520 – 1549DisorderedSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1879 Eukaryota
ENOG410XRK6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6X5P8

TreeFam database of animal gene trees

More...
TreeFami
TF300320

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040497 Glyco_transf_24
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
IPR040693 UGGT_TRXL_1
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3
IPR040525 UGGT_TRXL_4

The PANTHER Classification System

More...
PANTHERi
PTHR11226 PTHR11226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18400 Thioredoxin_12, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit
PF18403 Thioredoxin_15, 1 hit
PF06427 UDP-g_GGTase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F6X5P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRKGDASGV CAAAARPVTG VCYKMGLLIV LTGLWLFSSV KADSKAITTS
60 70 80 90 100
LTTKWFSTPL LLEASEFLAE DSQEKFWNFV EASENIGSSD HHDTDSSYYQ
110 120 130 140 150
AILEAAFQFL SPLQQNLLKF CLSLRSYSAT IQAFQQIAAD EPPPEGCNSF
160 170 180 190 200
FSVHGKKTCD FDALETLLPT ASERPKPLLF KGDHRYPSSD PESPVVIFYS
210 220 230 240 250
EIGYEEFYNF HRQLTSKSSA GKINYVFRHY VSNPRKEPVY LSGYGVELAI
260 270 280 290 300
KSTEYKAKDD TQVKGTEVNT TVIGENDPID EVQGFLFGKL RDLHPALKEQ
310 320 330 340 350
LKELRKHLVE STNEMAPLKV WQLQDLSFQT AARILAAPVE LALVIMKDLS
360 370 380 390 400
QNFPTKARAI TKTAVSSELR TEVEENQKYF KGTLGLQPGD SALFINGLHI
410 420 430 440 450
DLDTQDIFSL VDVLKNEARV MEGLHRLGIE GLSLHNVLKL NTQPSEADYA
460 470 480 490 500
VDIRSPAISW INNLEVDSRY NSWPSSLQEL LRPTFPGVIR QIRKNLHNMV
510 520 530 540 550
FIVDPAHETT AELMNTAEMF LSNHIPLRLG LIFVVNDSED IDGMQDAGVA
560 570 580 590 600
VLRAHNYVAQ EADDYHAFQT LIHIYNKVRT GEKVKVEHVV SVLEKKYPYV
610 620 630 640 650
EVNSILGIDS AYDQNRKEAR SYYEQTGVGP LPVVLFNGMP LEKEQLDPDE
660 670 680 690 700
LETITMHKIL ETTTFFQRAV YLGELSHDQD VVEYIMNQPN VVPRINSRIL
710 720 730 740 750
TAERQYLDLT ATNNFFVDDY ARFTVLDSQG KTAAIANSMN YLTKKDDSFI
760 770 780 790 800
RPVTFWIVGD FDSPSGRQLL YDAIKHQKSS NNVRISMINN PSDDVTYENT
810 820 830 840 850
QISRAIWTAL QTQTSNSAKN FITKMAKEET AEALAAGADI GEFSVGGMDF
860 870 880 890 900
SLFKEVFESS KMDFILSHAM YCRDVLKLKK GQRAVISNGR IIGPLEDSEL
910 920 930 940 950
FNQDDFHLLE NIILKTSGQK IKSHIQQLRV EEDVASDLVM KVDALLSAQP
960 970 980 990 1000
KGDARIEYQF FEDRHSAIKL RPKEGETYFD VVAVIDPVTR EAQRLAPLLL
1010 1020 1030 1040 1050
VLTQLINMNL RVFMNCQSKL SDMPLKSFYR YVLEPEISFT SDNSFAKGPI
1060 1070 1080 1090 1100
AKFLDMPQSP LFTLNLNTPE SWMVESVRTP YDLDNIYLEE VDSVVAAEYE
1110 1120 1130 1140 1150
LEYLLLEGHC YDITTGQPPR GLQFTLGTSA SPVIVDTIVM ANLGYFQLKA
1160 1170 1180 1190 1200
NPGAWILRLR KGRSEDIYRV YSHDGTDSPP DADEVVVVLN NFRSKIIKVK
1210 1220 1230 1240 1250
VQKKADMVNE DLLSDGTNEN ESGFWDSFKW GFTGGQKTEE VKQDKDDIIN
1260 1270 1280 1290 1300
IFSVASGHLY ERFLRIMMLS VLKNTKTPVK FWFLKNYLSP TFKEFIPYMA
1310 1320 1330 1340 1350
NEYSFQYELV QYKWPRWLHQ QTEKQRIIWG YKILFLDVLF PLVVDKFLFV
1360 1370 1380 1390 1400
DADQIVRTDL KELRDFNLDG APYGYTPFCD SRREMDGYRF WKSGYWASHL
1410 1420 1430 1440 1450
AGRKYHISAL YVVDLKKFRK IAAGDRLRGQ YQGLSQDPNS LSNLDQDLPN
1460 1470 1480 1490 1500
NMIHQVPIKS LPQEWLWCET WCDDASKKRA KTIDLCNNPM TKEPKLEAAV
1510 1520 1530 1540
RIVPEWQDYD QEIKQLQMRF QKEKETGALH KEKTVPEPSR EGPQKREEL
Length:1,549
Mass (Da):176,541
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B7EEE6B3F99AF56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2GRS8A0A3Q2GRS8_HORSE
UDP-glucose glycoprotein glucosyltr...
UGGT1
1,557Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GVI2A0A3Q2GVI2_HORSE
UDP-glucose glycoprotein glucosyltr...
UGGT1
1,522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I4N1A0A3Q2I4N1_HORSE
UDP-glucose glycoprotein glucosyltr...
UGGT1
1,496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000023316; ENSECAP00000019303; ENSECAG00000021191

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6X5P8
PRIDEiF6X5P8

Genome annotation databases

EnsembliENSECAT00000023316; ENSECAP00000019303; ENSECAG00000021191

Organism-specific databases

VGNCiVGNC:24776 UGGT1

Phylogenomic databases

eggNOGiKOG1879 Eukaryota
ENOG410XRK6 LUCA
GeneTreeiENSGT00390000004600
InParanoidiF6X5P8
TreeFamiTF300320

Gene expression databases

BgeeiENSECAG00000021191 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR040497 Glyco_transf_24
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
IPR040693 UGGT_TRXL_1
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3
IPR040525 UGGT_TRXL_4
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18400 Thioredoxin_12, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit
PF18403 Thioredoxin_15, 1 hit
PF06427 UDP-g_GGTase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6X5P8_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6X5P8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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