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Protein

Fibroblast growth factor

Gene

fgf4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-XTR-109704 PI3K Cascade
R-XTR-1257604 PIP3 activates AKT signaling
R-XTR-190322 FGFR4 ligand binding and activation
R-XTR-190372 FGFR3c ligand binding and activation
R-XTR-190373 FGFR1c ligand binding and activation
R-XTR-190375 FGFR2c ligand binding and activation
R-XTR-5654219 Phospholipase C-mediated cascade: FGFR1
R-XTR-5654221 Phospholipase C-mediated cascade, FGFR2
R-XTR-5654227 Phospholipase C-mediated cascade, FGFR3
R-XTR-5654228 Phospholipase C-mediated cascade, FGFR4
R-XTR-5654687 Downstream signaling of activated FGFR1
R-XTR-5654688 SHC-mediated cascade:FGFR1
R-XTR-5654689 PI-3K cascade:FGFR1
R-XTR-5654693 FRS-mediated FGFR1 signaling
R-XTR-5654695 PI-3K cascade:FGFR2
R-XTR-5654699 SHC-mediated cascade:FGFR2
R-XTR-5654700 FRS-mediated FGFR2 signaling
R-XTR-5654704 SHC-mediated cascade:FGFR3
R-XTR-5654706 FRS-mediated FGFR3 signaling
R-XTR-5654710 PI-3K cascade:FGFR3
R-XTR-5654712 FRS-mediated FGFR4 signaling
R-XTR-5654719 SHC-mediated cascade:FGFR4
R-XTR-5654720 PI-3K cascade:FGFR4
R-XTR-5654726 Negative regulation of FGFR1 signaling
R-XTR-5654727 Negative regulation of FGFR2 signaling
R-XTR-5654732 Negative regulation of FGFR3 signaling
R-XTR-5654733 Negative regulation of FGFR4 signaling
R-XTR-5658623 FGFRL1 modulation of FGFR1 signaling
R-XTR-5673001 RAF/MAP kinase cascade
R-XTR-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:fgf4Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-480496 fgf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 36HelicalSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF6WY95

Expressioni

Gene expression databases

BgeeiENSXETG00000001992
ExpressionAtlasiF6WY95 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000004269

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
InParanoidiF6WY95
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028239 FGF4
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF31 PTHR11486:SF31, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

F6WY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KTFGQFSFLV SLCCLRMTVP SALVPILLLG MAAVVVQGLP LSSSLRNDTL
60 70 80 90 100
ERRWETLFSR SMARIPGEKR DMSRESDYLL GIKRLRRLYC NVGIGFHIQV
110 120 130 140 150
LPDGRINGMH NENRYSLLEI SPVEVGVVSL YGVKSAMFVA MNAKGKLYGS
160 170 180 190 200
RHFNDECKFK ETLLPNNYNA YESRKYPGMY IALSKNGRTK KGNRVSPTMT

LTHFLPRI
Length:208
Mass (Da):23,558
Last modified:July 27, 2011 - v1
Checksum:i9D3BE7CBD380A5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01030090 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000004269; ENSXETP00000004269; ENSXETG00000001992

Similar proteinsi

Entry informationi

Entry nameiF6WY95_XENTR
AccessioniPrimary (citable) accession number: F6WY95
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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