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Protein
Submitted name:

Cholinergic receptor, nicotinic gamma

Gene

chrng

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-XTR-629587 Highly sodium permeable acetylcholine nicotinic receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic gammaImported
Gene namesi
Name:chrngImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-990010 chrng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei305 – 328HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500334482621 – 470Sequence analysisAdd BLAST450

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF6WX69

Expressioni

Gene expression databases

BgeeiENSXETG00000013994

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000030553

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 238Neur_chan_LBDInterPro annotationAdd BLAST214
Domaini245 – 469Neur_chan_membInterPro annotationAdd BLAST225

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
InParanoidiF6WX69
OMAiEEWFLVG
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

F6WX69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RGGMDTVLLL VLICISAALC HNEEEGLLND LMKNYNKNLR PAEKDGDIVS
60 70 80 90 100
VSIKLTLTNL ISLNEREEAL TTNVWVEVQW RDYRLSWDPN EYYGISMMRI
110 120 130 140 150
PSTSVWLPDV GLENNVDGTF DIALYANTLV SSDGSMYWLP PAIYRSSCPV
160 170 180 190 200
VVTYFPFDWQ NCSMVFQSQT YSANEIELLL TVDEQTIEWI EIDPEAFTEN
210 220 230 240 250
GEWAIKHMPA KKIINHRLTP DDLNYQQIVF YLIIQRKPLF YIINIIVPCV
260 270 280 290 300
LISFVSILVY FLPAKAGGQK CTVSINILLA QTVFLFLIAQ KIPETSTAVP
310 320 330 340 350
LIVKYLTFLM VVTITIVANA VIVLNISLRT PNTHSMSSTV RELCLRTVPR
360 370 380 390 400
LLRMHLRPSD AAPPLAPLMR RSSSVGLMIK ADEYMLRKPR SQLMFEKQKE
410 420 430 440 450
RDGLMKVVLD KIGRGMENNT SDDLVHSLKH AAPEIRACVE ACCHIASATR
460 470
EKNEFKSTGD NDWKCQSKVL
Length:470
Mass (Da):53,299
Last modified:July 27, 2011 - v1
Checksum:iBA2340B3D09823B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01069416 Genomic DNA No translation available.
AAMC01069417 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000030553; ENSXETP00000030553; ENSXETG00000013994

Similar proteinsi

Entry informationi

Entry nameiF6WX69_XENTR
AccessioniPrimary (citable) accession number: F6WX69
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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