UniProtKB - F6WM24 (F6WM24_XENTR)
Protein
Submitted name:
Regulatory factor X1
Gene
rfx1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- inflammatory response Source: InterPro
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Regulatory factor X1Imported |
Gene namesi | Name:rfx1Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-994757, rfx1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSXETG00000005567, Expressed in testis and 11 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000012247 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 342 – 417 | RFX-type winged-helixInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 191 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 810 – 866 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 161 – 191 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 810 – 824 | AcidicSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198514 |
HOGENOMi | CLU_010393_1_0_1 |
InParanoidi | F6WM24 |
TreeFami | TF321340 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR007668, RFX1_trans_act IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF04589, RFX1_trans_act, 1 hit PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F6WM24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQAYVTEL QAAAPAATQG TPQQYVAELQ VTPSGSSQAS GAQTPSAQQY
60 70 80 90 100
IVVTVSEGSV RGSDGELSPG GTPTPTTGVP TQVVQQVQAA QQRLLVQARV
110 120 130 140 150
QPKVTAVSPL QLAGSSVPQQ RLVVQSSPQG TKAAQVSLTV HTVQQQPAHS
160 170 180 190 200
PPDGDSPSLK AGQAQPLQLH GTQQERSVVQ ANPQKSSPVH QLTVQALQHV
210 220 230 240 250
QGAAEVQQLQ QVPVQHVYPS QVQYVEGTDA TYTGSTIRSG SYPYTETPLY
260 270 280 290 300
TQATGSTYYE AQGATGQVSS PTSSPALASS PSVPMYVSGG QILTNTTQSA
310 320 330 340 350
ASGGTGGGGS GSGTGTYVIQ GGFIMGSSTQ SYSHTTRASP ATVQWLLDNY
360 370 380 390 400
ETAEGVSLPR STLYCHYLLH CQEQKLEPVN AASFGKLIRS VFMGLRTRRL
410 420 430 440 450
GTRGNSKYHY YGLRIKASSP LLRLMEDQQH LAMRQQPFSQ KQRLKTVQKM
460 470 480 490 500
EGMSNGVGGS QQQASGLSDI SAQVQQYQQF LDASKTLPEF AEMDLQGKPL
510 520 530 540 550
PDGVTLANVK AFQLLYREHC EAIVDVVVNL QFTLVETLWK TFWRFNQTQH
560 570 580 590 600
SDSTIDDEAE KRLPKDCLVL LSKYEPLLKW SRDCDHLLYQ VLVETLIPDV
610 620 630 640 650
LRPIPSALTQ AIRNFAKSLE SWLTSAMMNI PEEMVRVKAS AASAFAQTLR
660 670 680 690 700
RYTSLNHLAQ AARAVLQNTA QINQMLSDLN RVDFTNVQEQ ASWVCRCADR
710 720 730 740 750
VVQRLEQDFK LTLQQQSSLE QWAEWLDSVV SQVLKPYQGS PGFPKAAKLF
760 770 780 790 800
LLKWSFYSSM VIRDLTLRSA ASFGSFHLIR LLYDEYMYYL IEHRVAQARG
810 820 830 840 850
ETPIAVMGEV KEEEEEEDES DEDLTHDLPL TMSDPSGALG SDSLEPPAKL
860
ARSDSQAIFV QVPPTS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8QKP1 | A0A6I8QKP1_XENTR | Regulatory factor X1 | rfx1 | 805 | Annotation score: | ||
A0A6I8SKZ4 | A0A6I8SKZ4_XENTR | Regulatory factor X1 | rfx1 | 823 | Annotation score: | ||
A0A6I8RCF5 | A0A6I8RCF5_XENTR | Regulatory factor X1 | rfx1 | 655 | Annotation score: | ||
A0A6I8S522 | A0A6I8S522_XENTR | Regulatory factor X1 | rfx1 | 709 | Annotation score: | ||
A0A6I8S5G6 | A0A6I8S5G6_XENTR | Regulatory factor X1 | rfx1 | 822 | Annotation score: | ||
A0A6I8SDV3 | A0A6I8SDV3_XENTR | Regulatory factor X1 | rfx1 | 677 | Annotation score: |
Sequence databases
RefSeqi | XP_002932904.1, XM_002932858.2 |
Genome annotation databases
Ensembli | ENSXETT00000012247; ENSXETP00000012247; ENSXETG00000005567 |
GeneIDi | 100494099 |
KEGGi | xtr:100494099 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_002932904.1, XM_002932858.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000012247 |
Proteomic databases
PaxDbi | F6WM24 |
Genome annotation databases
Ensembli | ENSXETT00000012247; ENSXETP00000012247; ENSXETG00000005567 |
GeneIDi | 100494099 |
KEGGi | xtr:100494099 |
Organism-specific databases
Xenbasei | XB-GENE-994757, rfx1 |
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198514 |
HOGENOMi | CLU_010393_1_0_1 |
InParanoidi | F6WM24 |
TreeFami | TF321340 |
Gene expression databases
Bgeei | ENSXETG00000005567, Expressed in testis and 11 other tissues |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR007668, RFX1_trans_act IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF04589, RFX1_trans_act, 1 hit PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6WM24_XENTR | |
Accessioni | F6WM24Primary (citable) accession number: F6WM24 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 2, 2020 | |
Last modified: | February 10, 2021 | |
This is version 50 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |