UniProtKB - F6WL78 (F6WL78_HORSE)
Protein
Non-specific serine/threonine protein kinase
Gene
WNK4
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: InterPro
- chloride channel inhibitor activity Source: GO_Central
- potassium channel inhibitor activity Source: GO_Central
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- ion homeostasis Source: GO_Central
- negative regulation of sodium ion transport Source: GO_Central
- positive regulation of ion transmembrane transporter activity Source: GO_Central
- positive regulation of potassium ion import across plasma membrane Source: GO_Central
- positive regulation of sodium ion transmembrane transporter activity Source: GO_Central
- protein phosphorylation Source: GO_Central
- renal sodium ion absorption Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:WNK4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:59308, WNK4 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023887, Expressed in adult mammalian kidney and 23 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 172 – 430 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 166 | DisorderedSequence analysisAdd BLAST | 166 | |
Regioni | 530 – 560 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 651 – 670 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 750 – 829 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 882 – 914 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 940 – 1108 | DisorderedSequence analysisAdd BLAST | 169 | |
Regioni | 1164 – 1241 | DisorderedSequence analysisAdd BLAST | 78 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 505 – 525 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 44 – 60 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 61 – 76 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 77 – 105 | Pro-richSequence analysisAdd BLAST | 29 | |
Compositional biasi | 141 – 161 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 531 – 555 | Pro-richSequence analysisAdd BLAST | 25 | |
Compositional biasi | 778 – 806 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 807 – 829 | Pro-richSequence analysisAdd BLAST | 23 | |
Compositional biasi | 882 – 905 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 946 – 972 | Pro-richSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1032 – 1057 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1067 – 1091 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1184 – 1202 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1213 – 1230 | PolarSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000159871 |
HOGENOMi | CLU_000550_2_1_1 |
InParanoidi | F6WL78 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6WL78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAPPAPETA VPMSQEEADL ALRSPPPFAA VGPPRLGPPP RRARRFSGKA
60 70 80 90 100
EPRPRSSRLS RRSSVDLGLL SSWSQPASPV PEPPDPPDSP NPGPARSPPP
110 120 130 140 150
SSGEPPEGTW TGAQVKATDS ALPELSGSAG GPGAGEPPRI PEAAARERRR
160 170 180 190 200
ELEEKEDTET QAVATSPDGR YLKFDIEIGR GSFKTVYRGL DTDTTVEVAW
210 220 230 240 250
CELQTRKLSR AERQRFSEEV EMLKGLQHPN IVRFYDSWKS VLRGQVCIVL
260 270 280 290 300
VTELMTSGTL KTYLRRFREM KPRVLQRWSR QILRGLHFLH SRVPPILHRD
310 320 330 340 350
LKCDNVFITG PTGSVKIGDL GLATLKRASF AKSVIGTPEF MAPEMYEEKY
360 370 380 390 400
DEAVDVYAFG MCMLEMATSE YPYSECQNAA QIYRKVTSGT KPNSFYKVKM
410 420 430 440 450
PEVKEIIEGC IRTDKNERFT IQDLLAHAFF REERGVHVEL AEEDDGEKPG
460 470 480 490 500
LKLWLRMEDA RRGGRPRDNQ AIEFLFQLGR DAAEEVAQEM VALGLVCEAD
510 520 530 540 550
YQPVARAVRE RVAAIQRKRE KLRKARELEA LPPVPGPPPA TVPMTPGPPS
560 570 580 590 600
VFPTEPEEPE ADQHQPFLFR HASYSSTTSD CETDGYLSSS GFLDASDPAL
610 620 630 640 650
QPPRGVPSSP AESHLRLPSA FALSIARSGP GSEFSPRDSY ASDAASGLCD
660 670 680 690 700
VGEGMGRMRR PPGRNLRRRP RSRLRVTSVS DQNDRVVECQ LQTHNSKMVT
710 720 730 740 750
FRFDLDGDSP EEIAAAMVYN EFILPSERAG FLSRIREIIQ RVETLLKRDT
760 770 780 790 800
GPVEAAEDPL GPQEEPAPMP VLSGPLPESS SAEVQSNTSQ EQRSWAAFST
810 820 830 840 850
SPSSPGTPLS PGDPFSPGTP VFPSPIFPIS SPPCHPSPSS FSPVSSQIFS
860 870 880 890 900
NLSPYSPSSP LPFSPSASQF PIPSSQFPLS SLLPSSPPTF SSSCSQVTLT
910 920 930 940 950
SSFPPCPSTS PLPSTTAAPL LSLASAFSLA VMTVAQSLLS PSPGLLSQSP
960 970 980 990 1000
PAPPGPLPSL PPLSPPPLAP CGQERASPLT AEVESEASPN PAQPLLGEAR
1010 1020 1030 1040 1050
LAPISEEGKP QLVGRFQVTS SKEPAEPLPL PTTSPTLSDI LKPPTPQMTS
1060 1070 1080 1090 1100
ESSDTEDSAG GGPEAREALA ESDRAAEGLG AGVEEGDDGK DPQVGGSPPP
1110 1120 1130 1140 1150
LSHPSPVWMN YSYSSLCLSS EDSESSGEDE EFWAELQSLR QKHLSEVETL
1160 1170 1180 1190 1200
QTLQKKEIED LYSRLGKQPP PGIVAPAAML SSRQRRLSKG SFPTSRRNSL
1210 1220 1230 1240
QRSEPPGLGI MRRNSLSGSS TGSQEQRASK GVTFAGDVGR M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PZK2 | A0A5F5PZK2_HORSE | Non-specific serine/threonine prote... | WNK4 | 1,246 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025748; ENSECAP00000021434; ENSECAG00000023887 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6WL78 |
Genome annotation databases
Ensembli | ENSECAT00000025748; ENSECAP00000021434; ENSECAG00000023887 |
Organism-specific databases
VGNCi | VGNC:59308, WNK4 |
Phylogenomic databases
GeneTreei | ENSGT00940000159871 |
HOGENOMi | CLU_000550_2_1_1 |
InParanoidi | F6WL78 |
Gene expression databases
Bgeei | ENSECAG00000023887, Expressed in adult mammalian kidney and 23 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6WL78_HORSE | |
Accessioni | F6WL78Primary (citable) accession number: F6WL78 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |