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UniProtKB - F6WL78 (F6WL78_HORSE)

Entry version 45 (10 Feb 2021)
Sequence version 3 (11 Dec 2019)
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Protein

Non-specific serine/threonine protein kinase

Gene

WNK4

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:59308, WNK4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6WL78

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000023887, Expressed in adult mammalian kidney and 23 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini172 – 430Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 166DisorderedSequence analysisAdd BLAST166
Regioni530 – 560DisorderedSequence analysisAdd BLAST31
Regioni651 – 670DisorderedSequence analysisAdd BLAST20
Regioni750 – 829DisorderedSequence analysisAdd BLAST80
Regioni882 – 914DisorderedSequence analysisAdd BLAST33
Regioni940 – 1108DisorderedSequence analysisAdd BLAST169
Regioni1164 – 1241DisorderedSequence analysisAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili505 – 525Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi44 – 60PolyampholyteSequence analysisAdd BLAST17
Compositional biasi61 – 76PolarSequence analysisAdd BLAST16
Compositional biasi77 – 105Pro-richSequence analysisAdd BLAST29
Compositional biasi141 – 161PolyampholyteSequence analysisAdd BLAST21
Compositional biasi531 – 555Pro-richSequence analysisAdd BLAST25
Compositional biasi778 – 806PolarSequence analysisAdd BLAST29
Compositional biasi807 – 829Pro-richSequence analysisAdd BLAST23
Compositional biasi882 – 905PolarSequence analysisAdd BLAST24
Compositional biasi946 – 972Pro-richSequence analysisAdd BLAST27
Compositional biasi1032 – 1057PolarSequence analysisAdd BLAST26
Compositional biasi1067 – 1091PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1184 – 1202PolarSequence analysisAdd BLAST19
Compositional biasi1213 – 1230PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000550_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6WL78

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6WL78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAPPAPETA VPMSQEEADL ALRSPPPFAA VGPPRLGPPP RRARRFSGKA 
        60         70         80         90        100
EPRPRSSRLS RRSSVDLGLL SSWSQPASPV PEPPDPPDSP NPGPARSPPP 
       110        120        130        140        150
SSGEPPEGTW TGAQVKATDS ALPELSGSAG GPGAGEPPRI PEAAARERRR 
       160        170        180        190        200
ELEEKEDTET QAVATSPDGR YLKFDIEIGR GSFKTVYRGL DTDTTVEVAW 
       210        220        230        240        250
CELQTRKLSR AERQRFSEEV EMLKGLQHPN IVRFYDSWKS VLRGQVCIVL 
       260        270        280        290        300
VTELMTSGTL KTYLRRFREM KPRVLQRWSR QILRGLHFLH SRVPPILHRD 
       310        320        330        340        350
LKCDNVFITG PTGSVKIGDL GLATLKRASF AKSVIGTPEF MAPEMYEEKY 
       360        370        380        390        400
DEAVDVYAFG MCMLEMATSE YPYSECQNAA QIYRKVTSGT KPNSFYKVKM 
       410        420        430        440        450
PEVKEIIEGC IRTDKNERFT IQDLLAHAFF REERGVHVEL AEEDDGEKPG 
       460        470        480        490        500
LKLWLRMEDA RRGGRPRDNQ AIEFLFQLGR DAAEEVAQEM VALGLVCEAD 
       510        520        530        540        550
YQPVARAVRE RVAAIQRKRE KLRKARELEA LPPVPGPPPA TVPMTPGPPS 
       560        570        580        590        600
VFPTEPEEPE ADQHQPFLFR HASYSSTTSD CETDGYLSSS GFLDASDPAL 
       610        620        630        640        650
QPPRGVPSSP AESHLRLPSA FALSIARSGP GSEFSPRDSY ASDAASGLCD 
       660        670        680        690        700
VGEGMGRMRR PPGRNLRRRP RSRLRVTSVS DQNDRVVECQ LQTHNSKMVT 
       710        720        730        740        750
FRFDLDGDSP EEIAAAMVYN EFILPSERAG FLSRIREIIQ RVETLLKRDT 
       760        770        780        790        800
GPVEAAEDPL GPQEEPAPMP VLSGPLPESS SAEVQSNTSQ EQRSWAAFST 
       810        820        830        840        850
SPSSPGTPLS PGDPFSPGTP VFPSPIFPIS SPPCHPSPSS FSPVSSQIFS 
       860        870        880        890        900
NLSPYSPSSP LPFSPSASQF PIPSSQFPLS SLLPSSPPTF SSSCSQVTLT 
       910        920        930        940        950
SSFPPCPSTS PLPSTTAAPL LSLASAFSLA VMTVAQSLLS PSPGLLSQSP 
       960        970        980        990       1000
PAPPGPLPSL PPLSPPPLAP CGQERASPLT AEVESEASPN PAQPLLGEAR 
      1010       1020       1030       1040       1050
LAPISEEGKP QLVGRFQVTS SKEPAEPLPL PTTSPTLSDI LKPPTPQMTS 
      1060       1070       1080       1090       1100
ESSDTEDSAG GGPEAREALA ESDRAAEGLG AGVEEGDDGK DPQVGGSPPP 
      1110       1120       1130       1140       1150
LSHPSPVWMN YSYSSLCLSS EDSESSGEDE EFWAELQSLR QKHLSEVETL 
      1160       1170       1180       1190       1200
QTLQKKEIED LYSRLGKQPP PGIVAPAAML SSRQRRLSKG SFPTSRRNSL 
      1210       1220       1230       1240 
QRSEPPGLGI MRRNSLSGSS TGSQEQRASK GVTFAGDVGR M
Length:1,241
Mass (Da):134,310
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F8E3F58EBA6D08E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5PZK2A0A5F5PZK2_HORSE
Non-specific serine/threonine prote...
WNK4
1,246Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000025748; ENSECAP00000021434; ENSECAG00000023887

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6WL78

Genome annotation databases

EnsembliENSECAT00000025748; ENSECAP00000021434; ENSECAG00000023887

Organism-specific databases

VGNCiVGNC:59308, WNK4

Phylogenomic databases

GeneTreeiENSGT00940000159871
HOGENOMiCLU_000550_2_1_1
InParanoidiF6WL78

Gene expression databases

BgeeiENSECAG00000023887, Expressed in adult mammalian kidney and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6WL78_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6WL78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 45 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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