Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - F6WKE5 (F6WKE5_HORSE)

Entry version 67 (10 Feb 2021)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor type 1

Gene

ITPR1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:19194, ITPR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2257 – 2279HelicalSequence analysisAdd BLAST23
Transmembranei2291 – 2309HelicalSequence analysisAdd BLAST19
Transmembranei2378 – 2403HelicalSequence analysisAdd BLAST26
Transmembranei2423 – 2445HelicalSequence analysisAdd BLAST23
Transmembranei2553 – 2576HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6WKE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000020933, Expressed in cerebellum and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6WKE5, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1005 – 1026DisorderedSequence analysisAdd BLAST22
Regioni1137 – 1169DisorderedSequence analysisAdd BLAST33
Regioni1738 – 1771DisorderedSequence analysisAdd BLAST34
Regioni1864 – 1889DisorderedSequence analysisAdd BLAST26
Regioni1915 – 1935DisorderedSequence analysisAdd BLAST21
Regioni2703 – 2732DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1593 – 1613Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1006 – 1023PolarSequence analysisAdd BLAST18
Compositional biasi1145 – 1163PolyampholyteSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155071

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6WKE5

TreeFam database of animal gene trees

More...TreeFami		TF312815

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF48371, SSF48371, 1 hit
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F6WKE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTIIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDADQDAS RSRLRNAQEK 
       360        370        380        390        400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICKAVLNPT NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW 
       710        720        730        740        750
RDSNKEIRSK SVRELAQDAK EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL 
       760        770        780        790        800
AINEISGQLD VDLILRCMSD ENLPYDLRAS FCRLMLHMHV DRDPQEQVTP 
       810        820        830        840        850
VKYARLWSEI PSEIAIDDYD NSGTSKDEIK ERFAQTMEFV EEYLRDVVCQ 
       860        870        880        890        900
RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 
       910        920        930        940        950
TTIFPISKMA KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 
       960        970        980        990       1000
PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE 
      1010       1020       1030       1040       1050
FDESNSQTSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL 
      1060       1070       1080       1090       1100
DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV 
      1110       1120       1130       1140       1150
QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD EAMDGASGEN 
      1160       1170       1180       1190       1200
EHKKTEEGNN KSQKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 
      1210       1220       1230       1240       1250
QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 
      1260       1270       1280       1290       1300
NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE 
      1310       1320       1330       1340       1350
THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS 
      1360       1370       1380       1390       1400
FQTLIQMMRS ERDRMDENSP LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL 
      1410       1420       1430       1440       1450
PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI YTSNHMWKLF 
      1460       1470       1480       1490       1500
ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF SSPFSDQSTT 
      1510       1520       1530       1540       1550
LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI 
      1560       1570       1580       1590       1600
PVDLDSQVNN LFLKSHNIVQ KTAMNWRLTA RNAARRDSVL AASRDYRNII 
      1610       1620       1630       1640       1650
ERLQDIVSAL EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG 
      1660       1670       1680       1690       1700
FICKLIKHTK QLLEENEEKL CIKVLQTLRE MMTKDRGYGE KLISIDELDN 
      1710       1720       1730       1740       1750
AELPQAPDSE NSTEGEALRQ ILVNRYYGNI RPSGRRESLT SFGNGPLSPG 
      1760       1770       1780       1790       1800
GPSKPGGGGG GSGSSSMSRG EMSLAEVQCH LDKEGASNLV IDLIMNASSD 
      1810       1820       1830       1840       1850
RVFHESILLA IALLEGGNTT IQHSFFCRLT EDKKSEKFFK VFYDRMKVAQ 
      1860       1870       1880       1890       1900
QEIKATVTVN TSDLGNKKKD DEIDRDAPSR KKAKEPTTQI TEEVRDQLLE 
      1910       1920       1930       1940       1950
ASAATRKAFT TFRREADPDD HYQSGEGAQA TADKTKDDLE MSAVITIMQP 
      1960       1970       1980       1990       2000
ILRFLQLLCE NHNRDLQNFL RCQNNKTNYN LVCETLQFLD CICGSTTGGL 
      2010       2020       2030       2040       2050
GLLGLYINEK NVALINQTLE SLTEYCQGPC HENQNCIATH ESNGIDIITA 
      2060       2070       2080       2090       2100
LILNDINPLG KKRMDLVLEL KNNASKLLLA IMESRHDSEN AERILYNMRP 
      2110       2120       2130       2140       2150
KELVEVIKKA YMQGEVEFED GENGEDGAAS PRNVGHNIYI LAHQLARHNK 
      2160       2170       2180       2190       2200
ELQNMLKPGG QVDGDEALEF YAKHTAQIEI VRLDRTMEQI VFPVPSICEF 
      2210       2220       2230       2240       2250
LTKESKLRIY YTTERDEQGS KINDFFLRSE DLFNEMNWQK KLRAQPVLYW 
      2260       2270       2280       2290       2300
CARNMSVWSS ISFNLAVLMN LLVAFFYPFK GVRGGTLEPH WSGLLWTAML 
      2310       2320       2330       2340       2350
ISLAIVIALP KPHGIRALIA STILRLIFSV GLQPTLFLLG AFNVCNKIIF 
      2360       2370       2380       2390       2400
LMSFVGNCGT FTRGYRAMVL DVEFLYHLLY LLICAMGLFV HEFFYSLLLF 
      2410       2420       2430       2440       2450
DLVYREETLL NVIKSVTRNG RSIILTAVLA LILVYLFSIV GYLFFKDDFI 
      2460       2470       2480       2490       2500
LEVDRLPNET ALPDAGESLA SEFLYSDVCR VETGENCSSP APKEELVPAE 
      2510       2520       2530       2540       2550
ETEQDKEHTC ETLLMCIVTV LSHGLRSGGG VGDVLRKPSK EEPLFAARVI 
      2560       2570       2580       2590       2600
YDLLFFFMVI IIVLNLIFGV IIDTFADLRS EKQKKEEILK TTCFICGLER 
      2610       2620       2630       2640       2650
DKFDNKTVTF EEHIKEEHNM WHYLCFIVLV KVKDSTEYTG PESYVAEMIK 
      2660       2670       2680       2690       2700
ERNLDWFPRM RAMSLVSSDS EGEQNELRNL QEKLESTMKL VTNLSGQLSE 
      2710       2720       2730 
LKDQMTEQRK QKQRIGLLGH PPHMNVNPQQ PA
Length:2,732
Mass (Da):311,034
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC873723310B629F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5Q0C9A0A5F5Q0C9_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,757Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YA86F6YA86_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,748Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y9R6F6Y9R6_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,737Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XRB0F6XRB0_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,709Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HF14A0A3Q2HF14_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,667Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IAV2A0A3Q2IAV2_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,742Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2LKT3A0A3Q2LKT3_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PNS4A0A5F5PNS4_HORSE
Inositol 1,4,5-trisphosphate recept...
ITPR1
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000023419; ENSECAP00000019394; ENSECAG00000020933

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6WKE5

Genome annotation databases

EnsembliENSECAT00000023419; ENSECAP00000019394; ENSECAG00000020933

Organism-specific databases

VGNCiVGNC:19194, ITPR1

Phylogenomic databases

GeneTreeiENSGT00940000155071
InParanoidiF6WKE5
TreeFamiTF312815

Gene expression databases

BgeeiENSECAG00000020933, Expressed in cerebellum and 21 other tissues
ExpressionAtlasiF6WKE5, baseline

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF48371, SSF48371, 1 hit
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6WKE5_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6WKE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: February 10, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again