UniProtKB - F6WH64 (F6WH64_HORSE)
Protein
Guanylate cyclase
Gene
GUCY1B1
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:4.6.1.2ARBA annotation
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- guanylate cyclase activity Source: UniProtKB-EC
- heme binding Source: InterPro
GO - Biological processi
- cGMP-mediated signaling Source: GO_Central
- trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: GO_Central
Keywordsi
Molecular function | LyaseUniRule annotationARBA annotation |
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GUCY1B1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18661, GUCY1B1 |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- presynaptic active zone Source: GO_Central
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000021009, Expressed in endometrium and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 421 – 554 | Guanylate cyclaseInterPro annotationAdd BLAST | 134 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 181 – 201 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 366 – 389 | Sequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157483 |
HOGENOMi | CLU_011614_4_0_1 |
InParanoidi | F6WH64 |
TreeFami | TF351403 |
Family and domain databases
Gene3Di | 3.30.450.260, 1 hit 3.30.70.1230, 1 hit 3.90.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR038158, H-NOX_domain_sf IPR011644, Heme_NO-bd IPR011645, HNOB_dom_associated IPR042463, HNOB_dom_associated_sf IPR024096, NO_sig/Golgi_transp_ligand-bd IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit PF07700, HNOB, 1 hit PF07701, HNOBA, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F6WH64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD
60 70 80 90 100
LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN
110 120 130 140 150
LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII
160 170 180 190 200
KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE
210 220 230 240 250
NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL PQLQPGNCSL
260 270 280 290 300
LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGTE
310 320 330 340 350
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR
360 370 380 390 400
DLVLLGEQFR EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP
410 420 430 440 450
SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG EGAMKIVNLL
460 470 480 490 500
NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA
510 520 530 540 550
LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT
560 570 580 590 600
SRTETTGEKG KINVSEYTYR CLMTPENSDP QFHLEHRGPV SMKGKKEPMQ
610
VWFLSRKNTG TEETQQDEN
Genome annotation databases
Ensembli | ENSECAT00000022682; ENSECAP00000018758; ENSECAG00000021009 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6WH64 |
Genome annotation databases
Ensembli | ENSECAT00000022682; ENSECAP00000018758; ENSECAG00000021009 |
Organism-specific databases
VGNCi | VGNC:18661, GUCY1B1 |
Phylogenomic databases
GeneTreei | ENSGT00940000157483 |
HOGENOMi | CLU_011614_4_0_1 |
InParanoidi | F6WH64 |
TreeFami | TF351403 |
Gene expression databases
Bgeei | ENSECAG00000021009, Expressed in endometrium and 21 other tissues |
Family and domain databases
Gene3Di | 3.30.450.260, 1 hit 3.30.70.1230, 1 hit 3.90.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR038158, H-NOX_domain_sf IPR011644, Heme_NO-bd IPR011645, HNOB_dom_associated IPR042463, HNOB_dom_associated_sf IPR024096, NO_sig/Golgi_transp_ligand-bd IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit PF07700, HNOB, 1 hit PF07701, HNOBA, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6WH64_HORSE | |
Accessioni | F6WH64Primary (citable) accession number: F6WH64 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |