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UniProtKB - F6WEQ6 (ZN692_RAT)
Protein
Zinc finger protein 692
Gene
Znf692
Organism
Rattus norvegicus (Rat)
Status
Functioni
May act as an transcriptional repressor for PCK1 gene expression, in turns may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 329 – 354 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 360 – 384 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 390 – 412 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 472 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of gluconeogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 692CuratedAlternative name(s): AICAR responsive element binding proteinBy similarity |
Gene namesi | Name:Znf692By similarity Synonyms:ArebpBy similarity, Zfp692Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306740, Zfp692 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000452720 | 1 – 533 | Zinc finger protein 692Add BLAST | 533 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 233 | PhosphoserineBy similarity | 1 | |
Modified residuei | 471 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation at Ser-471 results in loss of DNA-binding activity.By similarity
Keywords - PTMi
PhosphoproteinExpressioni
Gene expression databases
Bgeei | ENSRNOG00000002682, Expressed in cerebellum and 21 other tissues |
ExpressionAtlasi | F6WEQ6, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 251 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 290 – 310 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 478 – 533 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 145 – 182 | Basic and acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 187 – 209 | Acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 224 – 251 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 290 – 309 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 481 – 527 | Polar residuesSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 329 – 354 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 360 – 384 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 390 – 412 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 472 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000161175 |
HOGENOMi | CLU_045687_1_0_1 |
OMAi | YQFPCEI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | F6WEQ6 |
TreeFami | TF332664 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6WEQ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPVADASR RRREKRRQLD ARRSKCRIRL GGHMEQWCLL KERLGFSLHS
60 70 80 90 100
QLAKFLLDRY TSSGCVLCAG PEPVPQKGLQ YLVLLSHTHS RECSLVPGLR
110 120 130 140 150
GPGGGEGELV WECSAGHTFS WEPSLIPTPS EVPKQAPLTH TTERTWCSEA
160 170 180 190 200
RRKQEAEGLE CEHRERTQET RLSRRVEPPL ETDPSVGEDQ VVEEEEEEEE
210 220 230 240 250
EEEEEELLSD ASPWTYSSSP DDSEPDVPRP PPSPVTHTPK EGEIPPVPAT
260 270 280 290 300
LPTPCAVLAS LGSTAALTSD TEVQMELSRT SQVPAELQMT ESLDSPGSQA
310 320 330 340 350
QSAPNPTCDE DTAQIGLRRI RKAAKRELMP CDFPGCGRIF SNRQYLNHHK
360 370 380 390 400
KYQHIHQKSF CCPEPACGKS FNFKKHLKEH VKLHSDARDY ICEFCARSFR
410 420 430 440 450
TSSNLVIHRR IHTGEKPLQC EICGFTCRQK ASLNWHRRKH AETAAALRFP
460 470 480 490 500
CEFCGKRFEK PDSVVAHCSK SHPALLPVQE SPGSLGSSPS ISAPEPLQSP
510 520 530
EGTSFSTSYD SNPAPSTSIS SPGVPAPRNT EKS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K2F5 | A0A0G2K2F5_RAT | Zinc finger protein 692 | Zfp692 | 565 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097876 Genomic DNA No translation available. BC166433 mRNA Translation: AAI66433.1 |
RefSeqi | XP_006246445.1, XM_006246383.3 XP_006246446.1, XM_006246384.3 XP_006246447.1, XM_006246385.3 XP_006246448.1, XM_006246386.3 |
Genome annotation databases
Ensembli | ENSRNOT00000038123; ENSRNOP00000031984; ENSRNOG00000002682 |
GeneIDi | 303164 |
UCSCi | RGD:1306740, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097876 Genomic DNA No translation available. BC166433 mRNA Translation: AAI66433.1 |
RefSeqi | XP_006246445.1, XM_006246383.3 XP_006246446.1, XM_006246384.3 XP_006246447.1, XM_006246385.3 XP_006246448.1, XM_006246386.3 |
3D structure databases
SMRi | F6WEQ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000031984 |
Genome annotation databases
Ensembli | ENSRNOT00000038123; ENSRNOP00000031984; ENSRNOG00000002682 |
GeneIDi | 303164 |
UCSCi | RGD:1306740, rat |
Organism-specific databases
CTDi | 103836 |
RGDi | 1306740, Zfp692 |
Phylogenomic databases
GeneTreei | ENSGT00940000161175 |
HOGENOMi | CLU_045687_1_0_1 |
OMAi | YQFPCEI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | F6WEQ6 |
TreeFami | TF332664 |
Gene expression databases
Bgeei | ENSRNOG00000002682, Expressed in cerebellum and 21 other tissues |
ExpressionAtlasi | F6WEQ6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN692_RAT | |
Accessioni | F6WEQ6Primary (citable) accession number: F6WEQ6 Secondary accession number(s): B2GUW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 2, 2021 |
Last sequence update: | July 22, 2015 | |
Last modified: | February 23, 2022 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families