UniProtKB - F6WE69 (F6WE69_HORSE)
Protein
Submitted name:
Rho guanine nucleotide exchange factor 12
Gene
ARHGEF12
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
- GTPase activator activity Source: InterPro
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: InterPro
- Rho protein signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 12Imported |
Gene namesi | Name:ARHGEF12Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:15484, ARHGEF12 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022702, Expressed in oviduct epithelium and 23 other tissues |
ExpressionAtlasi | F6WE69, baseline |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 136 | PDZInterPro annotationAdd BLAST | 65 | |
Domaini | 740 – 930 | DHInterPro annotationAdd BLAST | 191 | |
Domaini | 972 – 1085 | PHInterPro annotationAdd BLAST | 114 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 530 – 671 | DisorderedSequence analysisAdd BLAST | 142 | |
Regioni | 1090 – 1154 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 1240 – 1291 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1338 – 1358 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1380 – 1421 | DisorderedSequence analysisAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 206 – 226 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 232 – 259 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 60 | PolyampholyteSequence analysisAdd BLAST | 48 | |
Compositional biasi | 530 – 549 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 581 – 595 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 613 – 659 | PolarSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1243 – 1258 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1270 – 1291 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1380 – 1419 | PolarSequence analysisAdd BLAST | 40 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157662 |
Family and domain databases
CDDi | cd13390, PH_LARG, 1 hit cd08754, RGS_LARG, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037801, ARHGEF12_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR037884, LARG_RGS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F6WE69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSA SHDFDPTDSS
60 70 80 90 100
SKKTKSSSEE SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED
110 120 130 140 150
GAAMRAGVQT GDRIIKVNGT LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG
160 170 180 190 200
SPQIPLADSE VEPSVIGHMS PIMTSPHSPG ASGNMERITS PVLMGEENNV
210 220 230 240 250
VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ EAKKHIPQLQ
260 270 280 290 300
EQLSKATGSA QSPKSGLKER IYLEENPEKS EVNQDIDTQS LIGSPSTRIA
310 320 330 340 350
PHIIGAEDDD FGTEHEQING QCSCFQSIEL LKSRPAHLAV FLHHVVSQFD
360 370 380 390 400
PATLLCYLYS DLYKQTNSKE TRRVFLEFHQ FFLDRSAHLK VSVPDEISVD
410 420 430 440 450
LDKRRPELIP EDLHRHYIQT MQEKVHPEVQ RHLEDFRQKR SMGLTLAESE
460 470 480 490 500
LTKLDAERDK DRVTLEKERA CAEQIVAKIE EVLMTAQAVE EDKSSTMQYV
510 520 530 540 550
ILMYMKHLGV KVKEPRNLEH KRGRIGFLPK IKQSMKKDRE GEEKGKRRGF
560 570 580 590 600
PSILGPPRRP SRHDNSAIGR AMELQKQRHP KHLSTPSSVS PEPQDPAKLR
610 620 630 640 650
QSGLASEGAD AGYLPANSTS SVVSGATLSQ EGGKENDTGS KQVGETPTSG
660 670 680 690 700
DSLDGTPRTP NTIFDFPPPP LDQVQEEEWE VERVTEHGTP KPFRKFDSIA
710 720 730 740 750
FGESQSEDEQ FENDLETDPP NWQQLVSREV LLGLKPCEIK RQEVINELFY
760 770 780 790 800
TERAHVRTLK VLDQVFYQRV SREGILSPSE LRKIFSNLED ILQLHIGLNE
810 820 830 840 850
QMKSVRKRNE TSVIDQIGED LLTWFSGPGE EKLKHAAATF CSNQPFALEM
860 870 880 890 900
IKSRQKKDSR FQTFVQDAES NPLCRRLQLK DIIPTQMQRL TKYPLLLDNI
910 920 930 940 950
AKYTEWPMER EKVKKAADHC RQILNYVNQA VKEAENKQRL EDYQRRLDTS
960 970 980 990 1000
NLKLSEYPNV EELRNLDLTK RKMIHEGPLV WKVNRDKTID LYTLLLDDIL
1010 1020 1030 1040 1050
VLLQKQDDRL VLRCHSKILA STADSKHTFS PVIKLNTVLV RQVATDNKAL
1060 1070 1080 1090 1100
FVISMSDNGA QIYELVAQTV SEKTVWQDLI CRMAASVKEQ STRPIPLPES
1110 1120 1130 1140 1150
PPCEGDNDEE EPPKLKVEHH GISVTGLQSP DRDLGLESPL ISSKPQSHSL
1160 1170 1180 1190 1200
GASGKSEVDD LFVAERQFAK EQRADGTLKE VGGNYQITIP NPHLPVSEER
1210 1220 1230 1240 1250
WALDALRNLG LLKQLLVQQL GLTEKSTQED WPHFPRYRTA SPGAQADSGT
1260 1270 1280 1290 1300
QNSETLKAYH PGEGQMPFRT GTGDISSCYG PRTSTESSAP QDSVVLAFQD
1310 1320 1330 1340 1350
GQASNILVMD HVIMTPEMPP AEPEGGLDES GEHFFDAREA HSDDNPSDGD
1360 1370 1380 1390 1400
GAVKKEEKDV NLRISGNYLI LDGYETVQES STDEEIASSL PSQPVTGIPS
1410 1420 1430 1440 1450
VDCTHQRQHS PQNARSDGAV SPFTPEFLVQ QRWGAMEDSC FEIQSPPSCA
1460 1470 1480 1490
DSQSQIMEYI HKIEADLEHL KKVEESYTIL CQRLAGSALT DKHSDKS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6VSJ2 | F6VSJ2_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,525 | Annotation score: | ||
F6W7T9 | F6W7T9_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,440 | Annotation score: | ||
A0A3Q2I9X8 | A0A3Q2I9X8_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,518 | Annotation score: | ||
A0A3Q2IJG3 | A0A3Q2IJG3_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,544 | Annotation score: | ||
A0A3Q2IE45 | A0A3Q2IE45_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,504 | Annotation score: | ||
A0A3Q2IE42 | A0A3Q2IE42_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,513 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024454; ENSECAP00000020313; ENSECAG00000022702 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000024454; ENSECAP00000020313; ENSECAG00000022702 |
Organism-specific databases
VGNCi | VGNC:15484, ARHGEF12 |
Phylogenomic databases
GeneTreei | ENSGT00940000157662 |
Gene expression databases
Bgeei | ENSECAG00000022702, Expressed in oviduct epithelium and 23 other tissues |
ExpressionAtlasi | F6WE69, baseline |
Family and domain databases
CDDi | cd13390, PH_LARG, 1 hit cd08754, RGS_LARG, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037801, ARHGEF12_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR037884, LARG_RGS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6WE69_HORSE | |
Accessioni | F6WE69Primary (citable) accession number: F6WE69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |