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UniProtKB - F6W871 (F6W871_MACMU)
Protein
Band 4.1
Gene
EPB41
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Molecular functioni
- 1-phosphatidylinositol binding Source: Ensembl
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- phosphoprotein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- structural molecule activity Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cortical actin cytoskeleton organization Source: InterPro
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein localization to cell cortex Source: Ensembl
- regulation of cell shape Source: Ensembl
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation |
Biological process | Cell cycle, Cell division, MitosisARBA annotation, TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Band 4.1ARBA annotationAlternative name(s): Erythrocyte membrane protein band 4.1ARBA annotation Protein 4.1ARBA annotation |
Gene namesi | Name:EPB41Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSMMUG00000011377 |
VGNCi | VGNC:72230, EPB41 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- cell cortex ARBA annotation
Cytoskeleton
- cortical cytoskeleton Source: Ensembl
- mitotic spindle Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- intercellular bridge Source: Ensembl
Nucleus
- nuclear body Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cell junction Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMMUG00000011377, Expressed in cerebellar cortex and 22 other tissues |
ExpressionAtlasi | F6W871, baseline |
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- phosphoprotein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 332 – 613 | FERMInterPro annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 29 – 324 | DisorderedSequence analysisAdd BLAST | 296 | |
Regioni | 640 – 690 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 709 – 737 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 811 – 845 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 902 – 926 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 739 – 759 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 177 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 178 – 198 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 215 – 245 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 280 – 324 | Basic and acidic residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 829 – 845 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157833 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 3 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F6W871-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGRAAGPAP SFPPARPNRN LLQCCGERRG RGARGRAGCG PGWPRLAEGR
60 70 80 90 100
REGARQGRSP ARSLARSLPP LVGLVSQPAA AGGPASRRGP KPGTPASPPA
110 120 130 140 150
IVRRAAAVAG AGARPRSHRN IMTTEKSLVT EAENSQHQQK EEGEGAINSG
160 170 180 190 200
QQEPQQEESC QTVAEGDNQF EQKLKASNGD TPTHEDLTKN KERTSESRGL
210 220 230 240 250
SRLFSSFLKR PKSQVSEEGG GKEVESDKEK GEGGQKEREF GTSLDEEIIL
260 270 280 290 300
KAPIAAPEPE LKTDPSLDLH SLSSAETQPA QEELREDPDF ETKEGEGLEE
310 320 330 340 350
CSKIEVKEES PESKAEGELK ASQKSIRKHR NMHCKVSLLD DTVYECVVEK
360 370 380 390 400
HAKGQDLLKR VCEHLNLLEE DYFGLAIWDN ATSKTWLDSA KEIKKQVRGV
410 420 430 440 450
PWNFTFNVKF YPPDPAQLTE DITRYYLCLQ LRQDIVAGRL PCSFATLALL
460 470 480 490 500
GSYTIQSELG DYDPELHGVD YVSDFKLAPN QTKELEEKVM ELHKSYRSMT
510 520 530 540 550
PAQADLEFLE NAKKLSMYGV DLHKAKDLEG VDIILGVCSS GLLVYKDKLR
560 570 580 590 600
INRFPWPKVL KISYKRSSFF IKIRPGEQEQ YESTIGFKLP SYRAAKKLWK
610 620 630 640 650
VCVEHHTFFR LTSTDTIPKS KFLALGSKFR YSGRTQAQTR QASALIDRPA
660 670 680 690 700
PHFERTASKR ASRSLDGAAA VDSADRSPRP TSAPAIAQGQ VAEGGVLDAS
710 720 730 740 750
AKKAVVPKAQ KETVKAEVKK EDEPPEQAEP EPTEAWKDLD KSQEEIRKHH
760 770 780 790 800
ASISELKKNF MESVPEPRPS EWDKRLSTHS PFRTLNVNGQ IPTGEGSING
810 820 830 840 850
IRTEEVAVVT KGPSTNPDSE WEGPKHSVVP SKSQMTTPSE SLQSFAFGSL
860 870 880 890 900
SISSKETEEK EEGAAGYLDI KEMPRGPTGE CIGVEEQAGA LKFSVTPASC
910 920 930 940 950
QLQPGEKKAE SSEEHVTPGE PLGKQNGSFL DFHPPLVKTQ TVTISDNTNA
960 970 980 990 1000
VKSEIPTKDV PIVHTETKTI TYEAAQTVKG GISETRIEKR IVITGDADID
1010 1020 1030
HDQVLVQAIK EAKEQHPDMS VTKVVVHQET EIADE
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6WEM9 | F6WEM9_MACMU | Band 4.1 | EPB41 | 998 | Annotation score: | ||
F6W853 | F6W853_MACMU | Band 4.1 | EPB41 | 1,019 | Annotation score: | ||
F6WE39 | F6WE39_MACMU | Band 4.1 | EPB41 | 961 | Annotation score: | ||
F6WE59 | F6WE59_MACMU | Band 4.1 | EPB41 | 1,005 | Annotation score: | ||
A0A1D5R026 | A0A1D5R026_MACMU | Band 4.1 | EPB41 | 1,015 | Annotation score: | ||
A0A1D5RGK7 | A0A1D5RGK7_MACMU | Band 4.1 | EPB41 | 831 | Annotation score: | ||
A0A5F7ZIH7 | A0A5F7ZIH7_MACMU | Band 4.1 | EPB41 | 980 | Annotation score: | ||
A0A5F7ZPS6 | A0A5F7ZPS6_MACMU | Band 4.1 | EPB41 | 982 | Annotation score: | ||
A0A5F8AA47 | A0A5F8AA47_MACMU | Band 4.1 | EPB41 | 981 | Annotation score: |
Genome annotation databases
Ensembli | ENSMMUT00000015933; ENSMMUP00000014932; ENSMMUG00000011377 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSMMUT00000015933; ENSMMUP00000014932; ENSMMUG00000011377 |
Organism-specific databases
VEuPathDBi | HostDB:ENSMMUG00000011377 |
VGNCi | VGNC:72230, EPB41 |
Phylogenomic databases
GeneTreei | ENSGT00940000157833 |
Gene expression databases
Bgeei | ENSMMUG00000011377, Expressed in cerebellar cortex and 22 other tissues |
ExpressionAtlasi | F6W871, baseline |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 3 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F6W871_MACMU | |
Accessioni | F6W871Primary (citable) accession number: F6W871 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | January 19, 2022 | |
This is version 70 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |