UniProtKB - F6W6H2 (F6W6H2_HORSE)
Protein
Neurofilament light polypeptide
Gene
NEFL
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein-macromolecule adaptor activity Source: Ensembl
- structural constituent of postsynaptic intermediate filament cytoskeleton Source: Ensembl
GO - Biological processi
- anterograde axonal transport Source: Ensembl
- axonal transport of mitochondrion Source: Ensembl
- locomotion Source: Ensembl
- microtubule cytoskeleton organization Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- neurofilament bundle assembly Source: Ensembl
- neurofilament cytoskeleton organization Source: Ensembl
- neuromuscular process controlling balance Source: Ensembl
- neuron projection morphogenesis Source: Ensembl
- peripheral nervous system axon regeneration Source: Ensembl
- positive regulation of axonogenesis Source: Ensembl
- regulation of axon diameter Source: Ensembl
- retrograde axonal transport Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Neurofilament light polypeptideARBA annotationAlternative name(s): Neurofilament triplet L proteinARBA annotation |
Gene namesi | Name:NEFLImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20662, NEFL |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- neurofilament Source: Ensembl
- presynaptic intermediate filament cytoskeleton Source: Ensembl
Other locations
- axon cytoplasm Source: GOC
- neuromuscular junction Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Cell projectionARBA annotation, CytoplasmARBA annotation, Intermediate filamentUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000022890, Expressed in prefrontal cortex and 17 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 90 – 401 | IF rodInterPro annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 463 – 572 | DisorderedSequence analysisAdd BLAST | 110 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 94 – 128 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 136 – 244 | Sequence analysisAdd BLAST | 109 | |
Coiled coili | 259 – 279 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 313 – 379 | Sequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 471 – 512 | AcidicSequence analysisAdd BLAST | 42 | |
Compositional biasi | 513 – 545 | PolyampholyteSequence analysisAdd BLAST | 33 | |
Compositional biasi | 555 – 572 | PolyampholyteSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156208 |
HOGENOMi | CLU_012560_7_4_1 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd IPR027692, NF-L |
PANTHERi | PTHR45652:SF8, PTHR45652:SF8, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF04732, Filament_head, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F6W6H2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSFSYEPYY STSYKRRYME TPRVHISSVR SGYSTARSAY SSYSAPVSSS
60 70 80 90 100
LSVRRSYSSS SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR
110 120 130 140 150
FASFIERVHE LEQQNKVLEA ELLVLRQKHS EPSRFRALYE QEIRDLRLAA
160 170 180 190 200
EDATNEKQAL QGEREGLEET LRNLQARYEE EVLSREDAEG RLMEARKGAD
210 220 230 240 250
EAALARAELE KRIDSLMDEI AFLKKVHEEE IAELQAQIQY AQISVEMDVS
260 270 280 290 300
SKPDLSAALK DIRAQYEKLA AKNMQNAEEW FKSRFTVLTE SAAKNTDAVR
310 320 330 340 350
AAKDEVSESR RLLKAKTLEI EACRGMNEAL EKQLQELEDK QNADISAMQD
360 370 380 390 400
TINKLENELR TTKSEMARYL KEYQDLLNVK MALDIEIAAY RKLLEGEETR
410 420 430 440 450
LSFTSVGSIT SGYTQTSQVF GRSAYGGLQT SSYLMSARSF PTYYTSHVQE
460 470 480 490 500
EQIEVEETIE AAKAEEAKDE PPSEGEAEEE EKEKEEAEEE EAAEEEEAAK
510 520 530 540 550
EESEEAKEEE AGGEGEEGAK VEEAAKVEEA KVEEGAKVEE AKVEEGEETK
560 570
EAEEEEKKDE GAGEEQAAKK KD
Sequence databases
RefSeqi | XP_005607746.1, XM_005607689.2 |
Genome annotation databases
Ensembli | ENSECAT00000024490; ENSECAP00000020346; ENSECAG00000022890 |
GeneIDi | 100054178 |
KEGGi | ecb:100054178 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005607746.1, XM_005607689.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000024490; ENSECAP00000020346; ENSECAG00000022890 |
GeneIDi | 100054178 |
KEGGi | ecb:100054178 |
Organism-specific databases
CTDi | 4747 |
VGNCi | VGNC:20662, NEFL |
Phylogenomic databases
GeneTreei | ENSGT00940000156208 |
HOGENOMi | CLU_012560_7_4_1 |
Gene expression databases
Bgeei | ENSECAG00000022890, Expressed in prefrontal cortex and 17 other tissues |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR006821, Intermed_filament_DNA-bd IPR027692, NF-L |
PANTHERi | PTHR45652:SF8, PTHR45652:SF8, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF04732, Filament_head, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6W6H2_HORSE | |
Accessioni | F6W6H2Primary (citable) accession number: F6W6H2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |