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UniProtKB - F6W4H3 (F6W4H3_HORSE)

Entry version 31 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Kinetochore associated 1

Gene

KNTC1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kinetochore associated 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNTC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:19502, KNTC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000021072, Expressed in trophectoderm and 21 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 772Rod_CInterPro annotationAdd BLAST286
Domaini1550 – 2098Rod_CInterPro annotationAdd BLAST549

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019552_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019527, RZZ-complex_KNTC1/ROD_C
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10493, Rod_C, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6W4H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWNDIELLTS DDTGSGYLSV GSRKEHGTAL YQVDLLAKVT SEKASLNPRI 
        60         70         80         90        100
QACSLSDGFI VVADQSVILL DGICRSLQLH LIFDTEVDVV GLCQEGKFLL 
       110        120        130        140        150
VGERSGNLHL IHVTSKQTLL TNAFVQKTND EDQCTYRNLV IEKDSSNEGT 
       160        170        180        190        200
YYMLLLTNNG FFCITNLQLV KIQQAIENAD FNKAKKLQGQ IKSRFISTEN 
       210        220        230        240        250
YHSLGCLNLV AGDLASEIPV IIGGTGSCAF SKWEPDSSKE GMTVKNVIDA 
       260        270        280        290        300
EIIEGAKKFQ LIDNLLFVLD TDNVLSLWDI YTLTPIWNWS SLHIEDFLLT 
       310        320        330        340        350
TEADSPSSVT WQGITNLKLV ALTTTTNKKM KNLMVYSLPT MEILYSLEVS 
       360        370        380        390        400
SISSLVQTGI STDTIYLLEG ICKNDPKLSE DSVSVLVLRC LTEALPENRL 
       410        420        430        440        450
SRLLHKHRFA EAESFAIQFG LDVELVYKVK SNDILEKLAL NSVDTSEQTE 
       460        470        480        490        500
WQTLVDEAKE NLHKIQDDEF VVNYCLEAQW ITYETTQEML NYAKARLLKK 
       510        520        530        540        550
EDKTVPIYSD GLKEVLRAHA KLTTFYGAFG PEKFSGSSWI EFLNNEDDLK 
       560        570        580        590        600
DIFLQLREGN LVCAQYLWLR HRANFESRFD VKMLENLLNS ISTPVSLQKL 
       610        620        630        640        650
CPWLRNDVIP FVRKTVPEGQ KILAKWLEQA ARNLELTDKA NWPENGLQLA 
       660        670        680        690        700
EVFFTAEKPD ELGLASSWHW ISLKDYQNTE EVCQLRTLVN NLRELITLHR 
       710        720        730        740        750
KYNCKLTLSD FEKENTTTIV FRMFDKVLAP ELIPSILEKF IRVYMREHDL 
       760        770        780        790        800
QEEELLLLYI EDLLKRCSSK STSLFETAWE AKAMAVIGCL SDTDLIFDAV 
       810        820        830        840        850
LKIMYAAMVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM EMKKLLRGYG 
       860        870        880        890        900
IREVNLLNKE IMRVVRYILK QDVPSSLEDA LKVAQAYMLS DDEIYSLRII 
       910        920        930        940        950
DLIDREQGED CVPLLRSLPP AEAEKTAQRV IIWARLALQE EPDNSKEDKA 
       960        970        980        990       1000
WRMSVAKTSV DILKILRDAL KDNLQKKDEC EEILKLFKSV ASLQENFEVF 
      1010       1020       1030       1040       1050
LPFGDYSNSS LVAELREQYI KAHEVAQATH KPRSTAEPVA AEKSLSTESK 
      1060       1070       1080       1090       1100
LHRQALALQV SRQELEAELT LRALNNGNAE TALRKCRDLF KYHCNTDTGK 
      1110       1120       1130       1140       1150
LLFLTCQKLC QMLANDVPMT TPVGLNLPSE IHNLACQAAT ICSPDFLLDA 
      1160       1170       1180       1190       1200
LELCKYTLTA VELSRQCQMD DCGILMKTSF GTHKDPYEEW SYSDFFSEDG 
      1210       1220       1230       1240       1250
IVLESQMVLP VIYELISSLV PLAESRRHPL DSASLPYCSI SEGDGLILPI 
      1260       1270       1280       1290       1300
INSISALLQN LQESSQWELA LRFVVGSFGT CLQHSVSNFM NASLSEKLFG 
      1310       1320       1330       1340       1350
TATLVKPKHV VTELKEKAVM FVRGNATTLL HKVFNCRLVD LDLALGYCTL 
      1360       1370       1380       1390       1400
LPQKEVFENL WKLIDKAWQN YDKILAISLV GSQLASLYQE IEMELKFREL 
      1410       1420       1430       1440       1450
STDAQWGIRL GKLGISFQPV FRQHFLTKKD LIKALVENID MDTSLILEYC 
      1460       1470       1480       1490       1500
STFQLDCDAA LQLFIETLLQ NTNASQSQGD ASTESTRQQH SKLLAKAIEM 
      1510       1520       1530       1540       1550
VPLLTSTKDL VISLSGILHK ALSLLKHLKS YRRISPPVDV EYQYMLEHVI 
      1560       1570       1580       1590       1600
TLPSAAQTRL PFHLIFFGTA QNFWKILSTE LSEESFPTLL LISKLMKFSL 
      1610       1620       1630       1640       1650
DTLYMSTAKH VFEKKLKPKL LKLTQAKSST LINKEITRIT QTIESYLLSI 
      1660       1670       1680       1690       1700
VNPEWAVAIA ISLAQDIPEG SFKMSSLKFC LYLAERWLQN IPSQDETREK 
      1710       1720       1730       1740       1750
AEALLKKLHV QYRRSGTEAV LIAHKLNTAE YLRLIGKPAH LIVSLYEHPS 
      1760       1770       1780       1790       1800
VNQRIQNSSG TDYPDIHAAA KEIAEVNEIN LEKVWDMLLE KWLCPSTKPG 
      1810       1820       1830       1840       1850
EKPSELFELQ EDEALQRVLY LLLSRPIDYS SRMLFVFATS ATTTLGMRQL 
      1860       1870       1880       1890       1900
TFAHRTRALQ CLLYLADKET IESLFKKPIE EVKSYLKCIT FMASFETLNI 
      1910       1920       1930       1940       1950
PITYELFCNS PKEGMIKGLW KNHSHEATAV RLVTELCLEY KIYDLQLWNG 
      1960       1970       1980       1990       2000
LLQKLLGFSM IPYLRKVLTA ISSIHSLWQV PYFSKAWQRV VQIPLLSASC 
      2010       2020       2030       2040       2050
PLSSSQLSDC CESLIAVLEC PVSDDLDMIG VARQYVQLEL PAFALACLML 
      2060       2070       2080       2090       2100
MPHSEKRHQQ IKNFLGSCNP QIILQQLEEH MSTGQLAGFS HQIRNLILNN 
      2110       2120       2130       2140       2150
VINKKDFGIL AKTKYFQMLK LHTMNTNNIT DLVNYLANEL SLDEASVFIT 
      2160       2170 
EYAKHRGKPV PPDAAPCEIL KMFLSGS
Length:2,177
Mass (Da):247,053
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i270ADE10A42957FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6STV8F6STV8_HORSE
Kinetochore associated 1
KNTC1
2,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000022394; ENSECAP00000018507; ENSECAG00000021072

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000022394; ENSECAP00000018507; ENSECAG00000021072

Organism-specific databases

VGNCiVGNC:19502, KNTC1

Phylogenomic databases

GeneTreeiENSGT00390000007883
HOGENOMiCLU_019552_0_0_1

Gene expression databases

BgeeiENSECAG00000021072, Expressed in trophectoderm and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019527, RZZ-complex_KNTC1/ROD_C
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF10493, Rod_C, 2 hits
SUPFAMiSSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6W4H3_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6W4H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 31 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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