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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

ADH5

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.UniRule annotation

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenaseUniRule annotation (EC:1.1.1.284UniRule annotation)
Gene namesi
Name:ADH5Imported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000013456

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 166ADH_NInterPro annotationAdd BLAST122
Domaini214 – 339ADH_zinc_NInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
InParanoidiF6W0P4
OMAiCIGNVNT
OrthoDBiEOG091G08N3
TreeFamiTF300429

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

F6W0P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPLRRPEP ADMANQVIKC KAAVAWEAGK PLFIEEIEVA PPKAHEVRIK
60 70 80 90 100
IIATAVCHTD AYTLSGADPE GCFPVILGHE GAGIVESVGE GVTKLKAGDT
110 120 130 140 150
VIPLYIPQCG ECKFCLNPKT NLCQKIRVTQ GKGLMPDGTS RFTCKGKTIL
160 170 180 190 200
HYMGTSTFSE YTVVADISVA KIDPLAPLDK VCLLGCGIST GYGAAVNTAK
210 220 230 240 250
VEPGSVCAVF GLGGVGLAVI MGCKVAGASR IIGVDINKDK FARAKEFGAT
260 270 280 290 300
ECVNPQDFSK PIQEVLIEMT DGGVDYSFEC IGNVKVMRAA LEACHKGWGV
310 320 330 340 350
SVVVGVAASG EEIATRPFQL VTGRTWKGTA FGGWKSVESV PKLVSEYMSK
360 370 380
KIKVDEFVTH SLSFDEINEA FELMHSGKSI RTVVKI
Length:386
Mass (Da):41,051
Last modified:June 20, 2018 - v2
Checksum:iEC49E874A9DD80F7
GO

Sequence databases

RefSeqiXP_002745615.3, XM_002745569.4

Genome annotation databases

EnsembliENSCJAT00000014175; ENSCJAP00000013456; ENSCJAG00000007198
GeneIDi100395052

Similar proteinsi

Entry informationi

Entry nameiF6W0P4_CALJA
AccessioniPrimary (citable) accession number: F6W0P4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: July 18, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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