UniProtKB - F6VUY7 (F6VUY7_HUMAN)
Protein
Submitted name:
Transcription factor IIIB 90 kDa subunit
Gene
BRF1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- TBP-class protein binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- transcription preinitiation complex assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor IIIB 90 kDa subunitImported |
Gene namesi | Name:BRF1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11551 BRF1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185024 Expressed in 170 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | F6VUY7 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 56 | TFIIBInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 120 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 98 – 117 | PolarSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00390000010349 |
Family and domain databases
CDDi | cd00043 CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR000812 TFIIB IPR013150 TFIIB_cyclin |
PANTHERi | PTHR11618 PTHR11618, 1 hit |
Pfami | View protein in Pfam PF00382 TFIIB, 1 hit |
SUPFAMi | SSF47954 SSF47954, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F6VUY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTALRLLQRM KRDWMHTGRR PSGLCGAALL VAARMHDFRR TVKEVISVVK
60 70 80 90 100
VCESTLRKRL TEFEDTPTSQ LTIDEFMKID LEEECDPPSE EGGQTEAREP
110 120 130
PQASSWEGPS TTRRRSQLWH GCPGCGRGGF TLCP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ92994 | TF3B_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 BRF, GTF3B, TAF3B2, TAF3C | 677 | Annotation score: | ||
A3KN61 | A3KN61_HUMAN | BRF1 protein | BRF1 | 184 | Annotation score: | ||
F8VS45 | F8VS45_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 234 | Annotation score: | ||
F8VWT8 | F8VWT8_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 155 | Annotation score: | ||
Q3SYD7 | Q3SYD7_HUMAN | BRF1 protein | BRF1 | 161 | Annotation score: | ||
H0YIV6 | H0YIV6_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 185 | Annotation score: | ||
F8VWY1 | F8VWY1_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 45 | Annotation score: | ||
F8VXJ4 | F8VXJ4_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 63 | Annotation score: | ||
F8W123 | F8W123_HUMAN | Transcription factor IIIB 90 kDa su... | BRF1 | 14 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL512355 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000379932; ENSP00000369264; ENSG00000185024 |
UCSCi | uc059fzd.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL512355 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F6VUY7 |
Genome annotation databases
Ensembli | ENST00000379932; ENSP00000369264; ENSG00000185024 |
UCSCi | uc059fzd.1 human |
Organism-specific databases
HGNCi | HGNC:11551 BRF1 |
OpenTargetsi | ENSG00000185024 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000010349 |
Miscellaneous databases
ChiTaRSi | BRF1 human |
Gene expression databases
Bgeei | ENSG00000185024 Expressed in 170 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | F6VUY7 baseline and differential |
Family and domain databases
CDDi | cd00043 CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR000812 TFIIB IPR013150 TFIIB_cyclin |
PANTHERi | PTHR11618 PTHR11618, 1 hit |
Pfami | View protein in Pfam PF00382 TFIIB, 1 hit |
SUPFAMi | SSF47954 SSF47954, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VUY7_HUMAN | |
Accessioni | F6VUY7Primary (citable) accession number: F6VUY7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | July 31, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |