UniProtKB - F6VSJ2 (F6VSJ2_HORSE)
Protein
Submitted name:
Rho guanine nucleotide exchange factor 12
Gene
ARHGEF12
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
- GTPase activator activity Source: InterPro
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: InterPro
- Rho protein signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 12Imported |
Gene namesi | Name:ARHGEF12Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:15484, ARHGEF12 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022702, Expressed in oviduct epithelium and 23 other tissues |
ExpressionAtlasi | F6VSJ2, baseline |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 117 | PDZInterPro annotationAdd BLAST | 65 | |
Domaini | 768 – 958 | DHInterPro annotationAdd BLAST | 191 | |
Domaini | 1000 – 1113 | PHInterPro annotationAdd BLAST | 114 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 43 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 257 – 296 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 552 – 699 | DisorderedSequence analysisAdd BLAST | 148 | |
Regioni | 1118 – 1182 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 1268 – 1319 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1366 – 1386 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1408 – 1449 | DisorderedSequence analysisAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 187 – 207 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 213 – 240 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 42 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 552 – 577 | PolyampholyteSequence analysisAdd BLAST | 26 | |
Compositional biasi | 609 – 623 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 641 – 687 | PolarSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1271 – 1286 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1298 – 1319 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1408 – 1447 | PolarSequence analysisAdd BLAST | 40 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157662 |
HOGENOMi | CLU_003962_1_1_1 |
InParanoidi | F6VSJ2 |
TreeFami | TF106495 |
Family and domain databases
CDDi | cd13390, PH_LARG, 1 hit cd08754, RGS_LARG, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037801, ARHGEF12_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR037884, LARG_RGS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F6VSJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSA SHDFDPTGLV
60 70 80 90 100
QRCVIIQKDD NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG
110 120 130 140 150
TLVTHSNHLE VVKLIKSGSY VALTVQGRPP GSPQIPLADS EVEPSVIGHM
160 170 180 190 200
SPIMTSPHSP GASGNMERIT SPVLMGEENN VVHNQKVEIL RKMLQKEQER
210 220 230 240 250
LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS AQDGAVVTSS
260 270 280 290 300
KPLGDALTVS EVEADPGDGL GRIDYSSGDV SRHSSDNADS PKSGLKERIY
310 320 330 340 350
LEENPEKSEV NQDIDTQSLI GSPSTRIAPH IIGAEDDDFG TEHEQINGQC
360 370 380 390 400
SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKQTNSKETR
410 420 430 440 450
RVFLEFHQFF LDRSAHLKVS VPDEISVDLD KRRPELIPED LHRHYIQTMQ
460 470 480 490 500
EKVHPEVQRH LEDFRQKRSM GLTLAESELT KLDAERDKDR VTLEKERACA
510 520 530 540 550
EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV KEPRNLEHKR
560 570 580 590 600
GRIGFLPKIK QSMKKDREGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM
610 620 630 640 650
ELQKQRHPKH LSTPSSVSPE PQDPAKLRQS GLASEGADAG YLPANSTSSV
660 670 680 690 700
VSGATLSQEG GKENDTGSKQ VGETPTSGDS LDGTPRTPNT IFDFPPPPLD
710 720 730 740 750
QVQEEEWEVE RVTEHGTPKP FRKFDSIAFG ESQSEDEQFE NDLETDPPNW
760 770 780 790 800
QQLVSREVLL GLKPCEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR
810 820 830 840 850
EGILSPSELR KIFSNLEDIL QLHIGLNEQM KSVRKRNETS VIDQIGEDLL
860 870 880 890 900
TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP
910 920 930 940 950
LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPMEREK VKKAADHCRQ
960 970 980 990 1000
ILNYVNQAVK EAENKQRLED YQRRLDTSNL KLSEYPNVEE LRNLDLTKRK
1010 1020 1030 1040 1050
MIHEGPLVWK VNRDKTIDLY TLLLDDILVL LQKQDDRLVL RCHSKILAST
1060 1070 1080 1090 1100
ADSKHTFSPV IKLNTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE
1110 1120 1130 1140 1150
KTVWQDLICR MAASVKEQST RPIPLPESPP CEGDNDEEEP PKLKVEHHGI
1160 1170 1180 1190 1200
SVTGLQSPDR DLGLESPLIS SKPQSHSLGA SGKSEVDDLF VAERQFAKEQ
1210 1220 1230 1240 1250
RADGTLKEVG GNYQITIPNP HLPVSEERWA LDALRNLGLL KQLLVQQLGL
1260 1270 1280 1290 1300
TEKSTQEDWP HFPRYRTASP GAQADSGTQN SETLKAYHPG EGQMPFRTGT
1310 1320 1330 1340 1350
GDISSCYGPR TSTESSAPQD SVVLAFQDGQ ASNILVMDHV IMTPEMPPAE
1360 1370 1380 1390 1400
PEGGLDESGE HFFDAREAHS DDNPSDGDGA VKKEEKDVNL RISGNYLILD
1410 1420 1430 1440 1450
GYETVQESST DEEIASSLPS QPVTGIPSVD CTHQRQHSPQ NARSDGAVSP
1460 1470 1480 1490 1500
FTPEFLVQQR WGAMEDSCFE IQSPPSCADS QSQIMEYIHK IEADLEHLKK
1510 1520
VEESYTILCQ RLAGSALTDK HSDKS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6W7T9 | F6W7T9_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,440 | Annotation score: | ||
F6WE69 | F6WE69_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,497 | Annotation score: | ||
A0A3Q2I9X8 | A0A3Q2I9X8_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,518 | Annotation score: | ||
A0A3Q2IJG3 | A0A3Q2IJG3_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,544 | Annotation score: | ||
A0A3Q2IE45 | A0A3Q2IE45_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,504 | Annotation score: | ||
A0A3Q2IE42 | A0A3Q2IE42_HORSE | Rho guanine nucleotide exchange fac... | ARHGEF12 | 1,513 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024539; ENSECAP00000020390; ENSECAG00000022702 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6VSJ2 |
Genome annotation databases
Ensembli | ENSECAT00000024539; ENSECAP00000020390; ENSECAG00000022702 |
Organism-specific databases
VGNCi | VGNC:15484, ARHGEF12 |
Phylogenomic databases
GeneTreei | ENSGT00940000157662 |
HOGENOMi | CLU_003962_1_1_1 |
InParanoidi | F6VSJ2 |
TreeFami | TF106495 |
Gene expression databases
Bgeei | ENSECAG00000022702, Expressed in oviduct epithelium and 23 other tissues |
ExpressionAtlasi | F6VSJ2, baseline |
Family and domain databases
CDDi | cd13390, PH_LARG, 1 hit cd08754, RGS_LARG, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037801, ARHGEF12_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR037884, LARG_RGS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VSJ2_HORSE | |
Accessioni | F6VSJ2Primary (citable) accession number: F6VSJ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |