UniProtKB - F6VP18 (F6VP18_HORSE)
Protein
Submitted name:
Hes family bHLH transcription factor 2
Gene
HES2
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hes family bHLH transcription factor 2Imported |
Gene namesi | Name:HES2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18757, HES2 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023427, Expressed in zone of skin and 11 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 70 | BHLHInterPro annotationAdd BLAST | 58 | |
Domaini | 86 – 119 | OrangeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 165 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 139 – 165 | Pro-richSequence analysisAdd BLAST | 27 |
Phylogenomic databases
GeneTreei | ENSGT00940000161602 |
HOGENOMi | CLU_068550_5_0_1 |
InParanoidi | F6VP18 |
OrthoDBi | 1427802at2759 |
TreeFami | TF351373 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6VP18-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLPRRTGDR AELRKSLKPL LEKRRRARIN ESLRQLKGLI LPLLGRESSC
60 70 80 90 100
YSKLEKADIL EMTVRFLQEL PASSCPAAAP APSDSYCEGY RACLARLARV
110 120 130 140 150
LPACRVLEPA VSARLLEHLR RRAAGASPNG RRAGDTCCPP SLSPPPPPAP
160
LPPVPPRGPG LWRPW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PJ87 | A0A5F5PJ87_HORSE | Hes family bHLH transcription facto... | HES2 | 77 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025114; ENSECAP00000020884; ENSECAG00000023427 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6VP18 |
Genome annotation databases
Ensembli | ENSECAT00000025114; ENSECAP00000020884; ENSECAG00000023427 |
Organism-specific databases
VGNCi | VGNC:18757, HES2 |
Phylogenomic databases
GeneTreei | ENSGT00940000161602 |
HOGENOMi | CLU_068550_5_0_1 |
InParanoidi | F6VP18 |
OrthoDBi | 1427802at2759 |
TreeFami | TF351373 |
Gene expression databases
Bgeei | ENSECAG00000023427, Expressed in zone of skin and 11 other tissues |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VP18_HORSE | |
Accessioni | F6VP18Primary (citable) accession number: F6VP18 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |