UniProtKB - F6VNY4 (F6VNY4_HORSE)
Protein
Receptor protein-tyrosine kinase
Gene
ERBB2
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 753 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 726 – 734 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
GO - Biological processi
- transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ERBB2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:17649, ERBB2 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 654 – 675 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5018577838 | 23 – 1203 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 1181 |
Keywords - PTMi
GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PaxDbi | F6VNY4 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020409, Expressed in trophoblast and 22 other tissues |
ExpressionAtlasi | F6VNY4, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 720 – 979 | Protein kinaseInterPro annotationAdd BLAST | 260 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 977 – 1127 | DisorderedSequence analysisAdd BLAST | 151 | |
Regioni | 1147 – 1203 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1090 – 1105 | Pro-richSequence analysisAdd BLAST | 16 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158232 |
HOGENOMi | CLU_003384_0_0_1 |
InParanoidi | F6VNY4 |
TreeFami | TF106002 |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 2 hits |
SMARTi | View protein in SMART SM00261, FU, 3 hits |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F6VNY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELAAWCRWG LLLALLPPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY
60 70 80 90 100
QGCQVVQGNL ELTYLPASAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR
110 120 130 140 150
IVRGTQLFED NYALAVLDNG DLLDNATSAT GAVPGGLREL QLRSLTEILK
160 170 180 190 200
GGVLIQRNPQ LCHQDTILWE DIFHKNNQLT LTLIDTNRSR ACQPCSPACR
210 220 230 240 250
PSHCWGESSE DCQNLTRTVC AGGCARCKGP RPTDCCHEQC AAGCTGPKHS
260 270 280 290 300
DCLACLHFNH SGICELHCPS LVIYNTDTFE SMPNPEGRYT FGASCVTACP
310 320 330 340 350
YNYLSTDVGS CTLVCPLNNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL
360 370 380 390 400
REVRAVTSAN IQDFAGCKKI FGSLAFLPES FEGDPASNTA PLQPEQLRVF
410 420 430 440 450
ETLEEITGYL YISAWPDSLP DLSVFQNLRV IRGRVLHDGA YSLTLQGLGI
460 470 480 490 500
SWLGLRSLQE LGSGLALVHH NARLCFVHTV PWAQLFRNPH QALLHSANRP
510 520 530 540 550
EDECVGEGLA CYPLCAHGHC WGPGPTQCVN CSQFLRGQEC VEECRVLQGL
560 570 580 590 600
PREYVKDRYC LPCHPECQPQ NGSVTCFGSE ADQCVACTHY KDPPFCVARC
610 620 630 640 650
PSGVKPDLSF MPIWKFPDEE GTCQPCPINC THSCLDLDDR GCPAEQRASP
660 670 680 690 700
VTSIIAAVVG ILLVVVIGLV LGILIKRRRQ KIRKYTMRRL LQETELVEPL
710 720 730 740 750
TPSGAMPNQA QMRILKETEL RKVKVLGSGA FGTVYKGIWI PDGENVKIPV
760 770 780 790 800
AIKVLRENTS PKANKEILDE AYVMAGVGSP YVSRLLGICL TSTVQLVTQL
810 820 830 840 850
MPYGCLLDHV REHRGRLGSQ DLLNWCVQIA KVPIKWMALE SILRRRFTHQ
860 870 880 890 900
SDVWSYGVTV WELMTFGAKP YDGIPAREIP DLLEKGERLP QPPICTIDVY
910 920 930 940 950
MIMVKCWMID SECRPRFREL VAEFSRMARD PQRFVVIQNE DLGPASPLDS
960 970 980 990 1000
TFYRSLLEDD DMGDLVDAEE YLVPQQGFFC PDPAPGAGGT AHRRHRSSSS
1010 1020 1030 1040 1050
RSGGGELTLG LEPSEEEPPK SPLAPSEGAG SDVFDGDLGM GAAKGLQSLP
1060 1070 1080 1090 1100
QHDPSPLQRY SEDPTVPLPP ETDGYVAPLS CSPQPEYVNQ PEVRPQPPSP
1110 1120 1130 1140 1150
LEGPLSPCRP DGATLERPKT LSPGKNGVVK DVFAFGGAVE NPEYLAPRSR
1160 1170 1180 1190 1200
AAPQPHPPPA FSPAFDNLYY WDQDPSERGS PPSTFEGTPT AENPEYLGLD
VPV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H4E6 | A0A3Q2H4E6_HORSE | Receptor protein-tyrosine kinase | ERBB2 | 1,255 | Annotation score: | ||
A0A5F5Q053 | A0A5F5Q053_HORSE | Receptor protein-tyrosine kinase | ERBB2 | 1,055 | Annotation score: | ||
A0A5F5PRG3 | A0A5F5PRG3_HORSE | Erb-b2 receptor tyrosine kinase 2 | ERBB2 | 979 | Annotation score: |
Sequence databases
RefSeqi | XP_014596215.1, XM_014740729.1 |
Genome annotation databases
Ensembli | ENSECAT00000022466; ENSECAP00000018571; ENSECAG00000020409 |
GeneIDi | 100054739 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_014596215.1, XM_014740729.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6VNY4 |
Genome annotation databases
Ensembli | ENSECAT00000022466; ENSECAP00000018571; ENSECAG00000020409 |
GeneIDi | 100054739 |
Organism-specific databases
CTDi | 2064 |
VGNCi | VGNC:17649, ERBB2 |
Phylogenomic databases
GeneTreei | ENSGT00940000158232 |
HOGENOMi | CLU_003384_0_0_1 |
InParanoidi | F6VNY4 |
TreeFami | TF106002 |
Gene expression databases
Bgeei | ENSECAG00000020409, Expressed in trophoblast and 22 other tissues |
ExpressionAtlasi | F6VNY4, baseline |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 2 hits |
SMARTi | View protein in SMART SM00261, FU, 3 hits |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VNY4_HORSE | |
Accessioni | F6VNY4Primary (citable) accession number: F6VNY4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 70 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |