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Entry version 69 (11 Dec 2019)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Immunoglobulin mu DNA binding protein 2

Gene

IGHMBP2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Immunoglobulin mu DNA binding protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGHMBP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:18977 IGHMBP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6VM18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000019360 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1803 Eukaryota
COG1112 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00930000151035

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6VM18

TreeFam database of animal gene trees

More...
TreeFami
TF105388

Family and domain databases

Conserved Domains Database

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CDDi
cd02641 R3H_Smubp-2_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.50, 1 hit
4.10.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035896 AN1-like_Znf
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034072 R3H_Smubp-2
IPR004483 SMUBP-2/Hcs1-like
IPR000058 Znf_AN1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF01424 R3H, 1 hit
PF01428 zf-AN1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00487 DEXDc, 1 hit
SM00393 R3H, 1 hit
SM00154 ZnF_AN1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118310 SSF118310, 1 hit
SSF52540 SSF52540, 1 hit
SSF82708 SSF82708, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00376 TIGR00376, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51061 R3H, 1 hit
PS51039 ZF_AN1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6VM18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAVESFV ARQLDLLELE RDAEVEERRS WQENISLKEL QSRGVCLLKL
60 70 80 90 100
QVSSQRTGLY GRLLVTFEPR RCVSSAVLPS NSFTSGDIVG LYDAANEGSQ
110 120 130 140 150
LATGILTRIT QKSVSVAFDE SHDCQLSLDR ESSYRLLKLA NDVTYKRQKK
160 170 180 190 200
ALITLRKYHS GPASSLIEVL FGASAPSPAS EIGPLTFCNA SLDASQKEAV
210 220 230 240 250
KFALSQKELA VIHGPPGTGK TTTVVEVILQ VVKQGLKVLC CAPSNIAVDN
260 270 280 290 300
LVERLAQCKQ RILRLGHPAR LLESIQQHSL DAVLARSDNA QIVADIRKDI
310 320 330 340 350
DQVFVKNKKI QEKQEKSNFR SEIKLLRKEL KEREEAAMLE SLTSADVVLA
360 370 380 390 400
TNTGASPDGP LKLLPDGYFD VVVIDECAQA LEASCWIPLL KARKCVLAGD
410 420 430 440 450
HKQLPPTIVS HKAALAGLSL SLMERLDQEY GARVVRTLTV QYRMHQAIMQ
460 470 480 490 500
WASEALYAGQ LTAHPSVAGH LLRDLPGVAA TEETGVPLLL VDTAGCGLFE
510 520 530 540 550
LEEEDEQSKG NPGEVRLVAL HVQALVDAGV CASDIAVITP YNLQVDLLRQ
560 570 580 590 600
SLAHRHPELE IKSVDGFQGR EKEAVILSFV RSNRKGEVGF LAEDRRINVA
610 620 630 640 650
VTRARRHVAV VCDSRTVNNH AFLKTLLDYC TVHGEVRTAF EYLDDIVPEN
660 670 680 690 700
YSHESSQGPG QAGVKSRGSA VPARKAPRSR QQEGPRGARA AAGLGQKPGG
710 720 730 740 750
RALGSEARCQ PSLNGGSPEG AESRDSADHF RALIADFMAS EETQLEFPAS
760 770 780 790 800
LNSHDRMQVH QIAEEHGLRH DSTGEGRKRF ITVSKRVPAS PPVPPPPPGP
810 820 830 840 850
VQTEPPVQEQ SGRDPLDLKA LHLERLQRER SGQERRAKDG PQAAGSGPRK
860 870 880 890 900
VPEKKKKKDG KGHAAMNLPA QEDFDALVSA AIKADNTCGF AKCTASVVTL
910 920 930 940 950
GQLCLHCGRR YCLSHHLPEI HGCGERARAH ARQRISREGV LYAGSGTKDR
960 970 980
ALDPAKRAQL QRKLDKKLGE LTSQRKSKRQ EREK
Length:984
Mass (Da):107,489
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE49443F37E88E21E
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000020699; ENSECAP00000016999; ENSECAG00000019360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6VM18

Genome annotation databases

EnsembliENSECAT00000020699; ENSECAP00000016999; ENSECAG00000019360

Organism-specific databases

VGNCiVGNC:18977 IGHMBP2

Phylogenomic databases

eggNOGiKOG1803 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00930000151035
InParanoidiF6VM18
TreeFamiTF105388

Gene expression databases

BgeeiENSECAG00000019360 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd02641 R3H_Smubp-2_like, 1 hit
Gene3Di3.30.1370.50, 1 hit
4.10.1110.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035896 AN1-like_Znf
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034072 R3H_Smubp-2
IPR004483 SMUBP-2/Hcs1-like
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF01424 R3H, 1 hit
PF01428 zf-AN1, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00487 DEXDc, 1 hit
SM00393 R3H, 1 hit
SM00154 ZnF_AN1, 1 hit
SUPFAMiSSF118310 SSF118310, 1 hit
SSF52540 SSF52540, 1 hit
SSF82708 SSF82708, 1 hit
TIGRFAMsiTIGR00376 TIGR00376, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit
PS51039 ZF_AN1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6VM18_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6VM18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: December 11, 2019
This is version 69 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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