UniProtKB - F6VAF4 (F6VAF4_HORSE)
Protein
Submitted name:
Tight junction protein 1
Gene
TJP1
Organism
Equus caballus (Horse)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Tight junction protein 1Imported |
Gene namesi | Name:TJP1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:24118, TJP1 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- tight junction ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000020528, Expressed in brainstem and 21 other tissues |
ExpressionAtlasi | F6VAF4, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 110 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 186 – 264 | PDZInterPro annotationAdd BLAST | 79 | |
Domaini | 421 – 502 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 516 – 584 | SH3InterPro annotationAdd BLAST | 69 | |
Domaini | 690 – 791 | Guanylate kinase-likeInterPro annotationAdd BLAST | 102 | |
Domaini | 1653 – 1787 | ZU5InterPro annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 103 – 189 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 296 – 363 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 825 – 944 | DisorderedSequence analysisAdd BLAST | 120 | |
Regioni | 957 – 977 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 988 – 1007 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1043 – 1064 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1096 – 1187 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 1228 – 1353 | DisorderedSequence analysisAdd BLAST | 126 | |
Regioni | 1365 – 1396 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1429 – 1606 | DisorderedSequence analysisAdd BLAST | 178 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 134 – 171 | PolyampholyteSequence analysisAdd BLAST | 38 | |
Compositional biasi | 172 – 186 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 298 – 326 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 848 – 864 | AcidicSequence analysisAdd BLAST | 17 | |
Compositional biasi | 890 – 906 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 914 – 944 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 963 – 977 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1108 – 1129 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1273 – 1290 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1338 – 1353 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1439 – 1453 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1479 – 1493 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1503 – 1551 | PolarSequence analysisAdd BLAST | 49 | |
Compositional biasi | 1582 – 1596 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155164 |
HOGENOMi | CLU_001538_1_0_1 |
InParanoidi | F6VAF4 |
TreeFami | TF315957 |
Family and domain databases
CDDi | cd12026, SH3_ZO-1, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005418, ZO-1 IPR035597, ZO-1_SH3 IPR000906, ZU5_dom |
PANTHERi | PTHR13865:SF25, PTHR13865:SF25, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01598, ZONOCCLUDNS1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F6VAF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSARAAATKN TVMEETAIWE QHTVTLHRAP GFGFGIAISG GRDNPHFQSG
60 70 80 90 100
ETSIVISDVL KGGPAEGQLQ ENDRVAMVNG VSMDNVEHAF AVQQLRKSGK
110 120 130 140 150
NAKITIRRKK KVQIPVSRPD PEPVSENEED SYDEEVHDPR SGRGGLINRR
160 170 180 190 200
SEKSWVRDRS ASRERSLSPR SDRRSVASSQ PAKPTKVTLV KSRKNEEYGL
210 220 230 240 250
RLASHIFVKE ISQDSLAARD GNIQEGDVVL KINGTVTENM SLTDAKTLIE
260 270 280 290 300
RSKGKLKMVV QRDERATLLN VPDLADSIHS ANASERDDIS EIQSLASDHS
310 320 330 340 350
GRSHDRPPRH SRSRSPDQRS EPSDHSRHSP QQPSNGSLRS REEERISKPG
360 370 380 390 400
AISTPVKHAD DHTPKTVEEV IVERNEKQAP TLPEPKPVYA QVGQPDVDLP
410 420 430 440 450
VSPSDGVLPN STHEDGILRP SMKLVKFRKG DSVGLRLAGG NDVGIFVAGV
460 470 480 490 500
LEDSPAAKEG LEEGDQILRV NNVDFTNIIR EEAVLFLLDL PKGEEVTILA
510 520 530 540 550
QKKKDVYRRI VESDVGDSFY IRTHFEYEKE SPYGLSFNKG EVFRVVDTLY
560 570 580 590 600
NGKLGSWLAI RIGKNHKEVE RGIIPNKNRA EQLASVQYTL PKTAGGDRAD
610 620 630 640 650
FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE AGFLRPVTIF
660 670 680 690 700
GPIADVAREK LAREEPDIYQ IAKSEPRDAG TDQRSSGIIR LHTIKQIIDQ
710 720 730 740 750
DKHALLDVTP NAVDRLNYAQ WYPIVVFLNP DSKQGVKTMR MRLCPESRKS
760 770 780 790 800
ARKLYERSHK LRKNNHHLFT TTINLNSMND GWYGALKEAI QQQQNQLVWV
810 820 830 840 850
SEGKADGATS DDLDLHDDRL SYLSAPGSEY SMYSTDSRHT SDYEDTDTEG
860 870 880 890 900
GAYTDQELDE TLNDEVGTPP ESAITRSSEP VREDSSGMHH ENQTYPSYSP
910 920 930 940 950
QAQPQPIHRI DSPGFKTASQ QKAEASSPVP YLSPETNPAS STSAVNHNVN
960 970 980 990 1000
LTNVRLEELT PAPPTSYSPQ ADSLRTPSSE AAHIMLRDQE ASLSSHVDPT
1010 1020 1030 1040 1050
KVYRKDPYPE DMMRQNHVLK QPAVGHPGQR ADKEPNLSYE AQPPYVEKQA
1060 1070 1080 1090 1100
SRDLEQPTYR YDSSSYAEQF SRNYDHRLHY EDRIPTYEEQ WSYYDDKQPY
1110 1120 1130 1140 1150
QPRPSFDNQH PRDLDSRQHP EESSERGYFP RFEEPTPLSY DSRPRYDQPP
1160 1170 1180 1190 1200
RTSTLRHEEQ AAPGYDIHNR YRPEAQPYSS AGHKASEAKQ YFDQYPRSYE
1210 1220 1230 1240 1250
QVPSQGLTSK AGHYEPLHGA AVVTPLIPAS QQKPEVLPSS TKPLPPPPTL
1260 1270 1280 1290 1300
TEEEEDPAMK PQSVLTRVKM FENKRSASLE NKKDENHTTS FKPPEVASKP
1310 1320 1330 1340 1350
PVAPIIGPKA TPQNQFSEHD KTLYRVPEPQ KPQLKPPEDI VRSNHYDPEE
1360 1370 1380 1390 1400
DEEYYRKQLS YFDRRSFENK PSPHIPASHL SEPAKPVPSQ NQTNFSGYSL
1410 1420 1430 1440 1450
KFLGSYTSYD YLKRNVKWGK STEADALERS FGEKRYDPIQ ATPPPPPLPS
1460 1470 1480 1490 1500
QYTQPSQPGS SSSLALHTHA KGGHGEGNSA SLDFQNSLVS KPDPPPSQNK
1510 1520 1530 1540 1550
PATFRPPNRE DTAQSAFYPQ KSFQDKAPIN GAEQTQKTVT PAYNRFTPKP
1560 1570 1580 1590 1600
YTSSARPFER KFESPKFNHN LLPGETAHKP DLSSKPPTSP KTLVKAHSSA
1610 1620 1630 1640 1650
QPPEFDSGVE TFSIHADKPK YQINNISTVP KAIPVSPSAM EEDEDEDGHT
1660 1670 1680 1690 1700
VVATARGVFN SNGGVLSSIE TGVSIIIPQG AIPEGIEQEI YFKVCRDNSI
1710 1720 1730 1740 1750
LPPLDKEKGE TLLSPLVMCG PHGLKFLKPV ELRLPHCASM TPDGWSFALK
1760 1770 1780
SSDSSSGDPK TWQNKCLPGD PNYLVGANCV SVLIDHF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HI47 | A0A3Q2HI47_HORSE | Tight junction protein 1 | TJP1 | 1,880 | Annotation score: | ||
A0A3Q2GVZ6 | A0A3Q2GVZ6_HORSE | Tight junction protein 1 | TJP1 | 1,690 | Annotation score: | ||
A0A3Q2HAP0 | A0A3Q2HAP0_HORSE | Tight junction protein 1 | TJP1 | 1,696 | Annotation score: | ||
A0A3Q2HZ12 | A0A3Q2HZ12_HORSE | Tight junction protein 1 | TJP1 | 1,834 | Annotation score: | ||
A0A3Q2I941 | A0A3Q2I941_HORSE | Tight junction protein 1 | TJP1 | 1,678 | Annotation score: | ||
A0A3Q2HYU6 | A0A3Q2HYU6_HORSE | Tight junction protein 1 | TJP1 | 382 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022218; ENSECAP00000018349; ENSECAG00000020528 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6VAF4 |
PRIDEi | F6VAF4 |
Genome annotation databases
Ensembli | ENSECAT00000022218; ENSECAP00000018349; ENSECAG00000020528 |
Organism-specific databases
VGNCi | VGNC:24118, TJP1 |
Phylogenomic databases
GeneTreei | ENSGT00940000155164 |
HOGENOMi | CLU_001538_1_0_1 |
InParanoidi | F6VAF4 |
TreeFami | TF315957 |
Gene expression databases
Bgeei | ENSECAG00000020528, Expressed in brainstem and 21 other tissues |
ExpressionAtlasi | F6VAF4, baseline |
Family and domain databases
CDDi | cd12026, SH3_ZO-1, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005418, ZO-1 IPR035597, ZO-1_SH3 IPR000906, ZU5_dom |
PANTHERi | PTHR13865:SF25, PTHR13865:SF25, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01598, ZONOCCLUDNS1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VAF4_HORSE | |
Accessioni | F6VAF4Primary (citable) accession number: F6VAF4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | October 7, 2020 | |
This is version 67 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |