UniProtKB - F6VA27 (F6VA27_HORSE)
Protein
Ras-related protein Rab-3
Gene
RAB3A
Organism
Equus caballus (Horse)
Status
Functioni
Protein transport. Probably involved in vesicular traffic.UniRule annotation
GO - Molecular functioni
- GTPase activity Source: Ensembl
- GTP binding Source: InterPro
- GTP-dependent protein binding Source: Ensembl
- myosin V binding Source: Ensembl
GO - Biological processi
- acrosomal vesicle exocytosis Source: Ensembl
- axonogenesis Source: GO_Central
- evoked neurotransmitter secretion Source: Ensembl
- lung development Source: Ensembl
- lysosome localization Source: Ensembl
- maintenance of presynaptic active zone structure Source: GO_Central
- mitochondrion organization Source: Ensembl
- neuromuscular synaptic transmission Source: Ensembl
- plasma membrane repair Source: Ensembl
- positive regulation of regulated secretory pathway Source: Ensembl
- post-embryonic development Source: Ensembl
- protein localization to plasma membrane Source: GO_Central
- protein secretion Source: GO_Central
- regulation of exocytosis Source: GO_Central
- regulation of plasma membrane repair Source: Ensembl
- regulation of short-term neuronal synaptic plasticity Source: Ensembl
- regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
- respiratory system process Source: Ensembl
- response to electrical stimulus Source: Ensembl
- sensory perception of touch Source: Ensembl
- synaptic vesicle clustering Source: Ensembl
- synaptic vesicle exocytosis Source: Ensembl
- synaptic vesicle maturation Source: Ensembl
- synaptic vesicle transport Source: Ensembl
- vesicle docking involved in exocytosis Source: GO_Central
Keywordsi
Biological process | Protein transportUniRule annotation, Transport |
Ligand | GTP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-3UniRule annotation |
Gene namesi | Name:RAB3AImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:22117, RAB3A |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Lipid-anchor UniRule annotationARBA annotation; Cytoplasmic side UniRule annotationARBA annotation
Endosome
- endosome Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- acrosomal vesicle Source: Ensembl
- anchored component of synaptic vesicle membrane Source: GO_Central
- axon Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- perinuclear region of cytoplasm Source: Ensembl
- presynaptic active zone Source: Ensembl
- synaptic vesicle Source: GO_Central
- terminal bouton Source: Ensembl
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membraneUniRule annotation, MembranePTM / Processingi
Keywords - PTMi
Lipoprotein, MethylationUniRule annotation, PrenylationUniRule annotationProteomic databases
PaxDbi | F6VA27 |
PRIDEi | F6VA27 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023115, Expressed in prefrontal cortex and 23 other tissues |
Interactioni
GO - Molecular functioni
- GTP-dependent protein binding Source: Ensembl
- myosin V binding Source: Ensembl
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 220 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000158959 |
HOGENOMi | CLU_041217_10_1_1 |
InParanoidi | F6VA27 |
TreeFami | TF313199 |
Family and domain databases
CDDi | cd01865, Rab3, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR037872, Rab3 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
i Sequence
Sequence statusi: Complete.
F6VA27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG
160 170 180 190 200
RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG
210 220
AKQGPQLTDQ QAPPHQDCAC
Sequence databases
RefSeqi | XP_001503278.1, XM_001503228.3 |
Genome annotation databases
Ensembli | ENSECAT00000024850; ENSECAP00000020664; ENSECAG00000023115 |
GeneIDi | 100069542 |
KEGGi | ecb:100069542 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001503278.1, XM_001503228.3 |
3D structure databases
SMRi | F6VA27 |
ModBasei | Search... |
Proteomic databases
PaxDbi | F6VA27 |
PRIDEi | F6VA27 |
Genome annotation databases
Ensembli | ENSECAT00000024850; ENSECAP00000020664; ENSECAG00000023115 |
GeneIDi | 100069542 |
KEGGi | ecb:100069542 |
Organism-specific databases
CTDi | 5864 |
VGNCi | VGNC:22117, RAB3A |
Phylogenomic databases
GeneTreei | ENSGT00940000158959 |
HOGENOMi | CLU_041217_10_1_1 |
InParanoidi | F6VA27 |
TreeFami | TF313199 |
Gene expression databases
Bgeei | ENSECAG00000023115, Expressed in prefrontal cortex and 23 other tissues |
Family and domain databases
CDDi | cd01865, Rab3, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR037872, Rab3 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6VA27_HORSE | |
Accessioni | F6VA27Primary (citable) accession number: F6VA27 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |