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Entry version 55 (29 Sep 2021)
Sequence version 4 (02 Jun 2021)
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Protein
Submitted name:

Envoplakin

Gene

evpl

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
EnvoplakinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:evplImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-993870, evpl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6V862

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000012599, Expressed in embryo and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000027569

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini355 – 419SH3_10InterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 507DisorderedSequence analysisAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili129 – 156Sequence analysisAdd BLAST28
Coiled coili322 – 349Sequence analysisAdd BLAST28
Coiled coili511 – 531Sequence analysisAdd BLAST21
Coiled coili563 – 583Sequence analysisAdd BLAST21
Coiled coili662 – 682Sequence analysisAdd BLAST21
Coiled coili880 – 927Sequence analysisAdd BLAST48
Coiled coili1011 – 1052Sequence analysisAdd BLAST42
Coiled coili1085 – 1112Sequence analysisAdd BLAST28
Coiled coili1145 – 1165Sequence analysisAdd BLAST21
Coiled coili1249 – 1269Sequence analysisAdd BLAST21
Coiled coili1313 – 1350Sequence analysisAdd BLAST38
Coiled coili1381 – 1438Sequence analysisAdd BLAST58
Coiled coili1464 – 1498Sequence analysisAdd BLAST35
Coiled coili1518 – 1556Sequence analysisAdd BLAST39
Coiled coili1564 – 1594Sequence analysisAdd BLAST31
Coiled coili1638 – 1665Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi441 – 462Polar residuesSequence analysisAdd BLAST22
Compositional biasi468 – 502Pro residuesSequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001780_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6V862

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPSQINY

TreeFam database of animal gene trees

More...
TreeFami
TF342779

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399, SSF75399, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6V862-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKNADQVER NILETDQKLK QDAGNYAAKK TFQHQQENAQ KLKDSEILLK
60 70 80 90 100
DLFLDVDKAK KYGHPQAQEI EQDIRHLHDR LSIECTEYRD LYEKMSILPP
110 120 130 140 150
EPKVNWPQIL DKKVQEIGNG QYGPSLPDVE RQIAEHNILQ RELDEYGNEI
160 170 180 190 200
RNQDNVAIKN QYRALQEEST WRSRHLGSLY NHLHGCTKEL MYLSDEQNKI
210 220 230 240 250
LKKDWSDQIP DLPATRRQYE KFKSEDLLPQ EENVNQLLDD GERMIELKHP
260 270 280 290 300
AAPCIQAHHE ALKGEWQNFL NLCICQENHL KNAEEYKKFH DDADAVSQTL
310 320 330 340 350
KEVNRNFDSK FSQGNLSAPG AASELQLHLE KEDKKLAQAE KNLSALKSKA
360 370 380 390 400
PEIVPIKQRR IRPKQPITIN SICDWDSADM QLSKGDACTL KDNSKVDSWV
410 420 430 440 450
VQTAGGETKN APSACFVIPP ADQEAIDKLK RLESELSEAQ KKKTAAQNTL
460 470 480 490 500
KSNRNREPAK PTQSFPVVTA PGPAPGPAPG PAPGPAPGPA PGPAPTPPTR
510 520 530 540 550
VSSIPSEDPQ ANQLLNKLNR IQDDLKDTEQ EVLSRVRSPV SQASPSKDLT
560 570 580 590 600
GRLKQQEGTA LRLQNIASEK DAVQKECEAF LNKSPSGTIA SQLPGTQANV
610 620 630 640 650
NNKYKDVKTL SSLYGEEAKA SLNLENQIKK TDDMISGFEN FLMQDALIPY
660 670 680 690 700
SPSALQDRAS EIQKMKRDLV DKQDNLLKLN RSLKDTELAC SSLQTNCQEH
710 720 730 740 750
SPDLPRQRVQ VQRLNDRYHS VADQLDQREK ILRDANLPYQ QYKSSCEAMD
760 770 780 790 800
TWLKGLPKNQ VSSSDSPSQV NYKLQSQKRL VDEIQRKEPE KNNVVKLSDD
810 820 830 840 850
LVNAFDDYEK QAGRYSSTLC SPNPVPPIKP KGVCMQQGIE DQQKDLVTRY
860 870 880 890 900
NQAAVESKQQ LTQMEFAKKV LDKSDSTDGI QAVNQQNLRS ENALRSARES
910 920 930 940 950
ENLSSQLVEE KKKVAQVQQA LEENTKRLIL LKTQRPVERI EEIEVVQYYK
960 970 980 990 1000
EPKVESDLSA RKSQAEKTNK EREITKSEII VVSKQLAALE EQRNNIKPQL
1010 1020 1030 1040 1050
LTKEVTQIER DPDLESKAQS LTKEIKQLKE ENNSISLELE RLKKEVLILE
1060 1070 1080 1090 1100
QKQPNIVEKV VLKEVVKLER DPETVKATRA LQLQIDDENF KRKSLQENMV
1110 1120 1130 1140 1150
KLRNRTEELE KLIESVEPKV IVKEVKKVEQ DPEILKEAAR LRTLIEEERN
1160 1170 1180 1190 1200
KSVVVTRELT ELQSRYVSVQ KQKPKIEIKE RVNEIFIVEP ETEKEIARLK
1210 1220 1230 1240 1250
SVLQEVSTKK SMSDKELDTS HTQMISLKSQ KPTVEYKEVV KEVVKLEKSP
1260 1270 1280 1290 1300
ELLKEIEKLK VQLKDMEATS VKNVGLKSKL AKERDDWKVE RSKVETKTVN
1310 1320 1330 1340 1350
KEVVKYENDP VLIKDAERLR QEARDEAQKR REVEDTVYDL QNKYMLLERR
1360 1370 1380 1390 1400
KPEERVVVQE VLLVKQDPKI KDDHFRLSRT LDDTVSNRRR LEREVQQLRT
1410 1420 1430 1440 1450
QVEEKQKLLN FQEERDKKLA AEKELRQITL RIKEIEERPP PVQEKIVMEE
1460 1470 1480 1490 1500
VVKVERDPVM EKAANSLRTD LDNELSQYLN IERECKNLQM KIDILQREKS
1510 1520 1530 1540 1550
LEKTIYKEVI RVEKDKVLEN ERVRLRELFS KARNARQDQE DESKRLTEKI
1560 1570 1580 1590 1600
ERVDAMKKTW SKEEVDLKKT KTQLQQEKST IENELLELRR QQQQKSVFLS
1610 1620 1630 1640 1650
KESQLLSQKA EIERQKKMQL GHELSLFESK ILSEKDAIYE KERNIRELQS
1660 1670 1680 1690 1700
RVNREERNQE TQMRETNVST KISILDPDTG KEMSPYEAYK RGIIDRSQYI
1710 1720 1730 1740 1750
QLQELECDWE EISTMGSSGE ISVLLDKKSG KQYSIEDALR NKKITKDELQ
1760 1770 1780 1790 1800
MYRDGKLPIS EFALLVAGEK PPAVSIGSII GPKSPTSTNL TTSRNFFSTQ
1810 1820 1830 1840 1850
SAPKVFHDES FPIAGIYDKS TDSKCTIRSA ITRKILDEET GQKLLEAQAA
1860 1870 1880 1890 1900
TGGIIHIMSK ERYSVHKAID RGLIDSSNTQ SLLHAQKAFT GVEDPVTKKR
1910 1920 1930 1940 1950
LSLGEAVQKD LIPKEKALPS LIVQHLTGGL IDTKQTGRIP VPEAEEQGLV
1960 1970 1980 1990 2000
SKELADKIQD ETQYKKDLID PVTKENISYK EAMSRCRKDP SSGLLLLEAS
2010 2020
DSYQPPLYRP VNPIPSLTTY NY
Length:2,022
Mass (Da):231,962
Last modified:June 2, 2021 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC7DA0BD22F0FDD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803KFS7A0A803KFS7_XENTR
Envoplakin
evpl
2,059Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000027569; ENSXETP00000027569; ENSXETG00000012599

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027569

Proteomic databases

PaxDbiF6V862

Genome annotation databases

EnsembliENSXETT00000027569; ENSXETP00000027569; ENSXETG00000012599

Organism-specific databases

XenbaseiXB-GENE-993870, evpl

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000153578
HOGENOMiCLU_001780_0_0_1
InParanoidiF6V862
OMAiGPSQINY
TreeFamiTF342779

Gene expression databases

BgeeiENSXETG00000012599, Expressed in embryo and 12 other tissues

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits
SUPFAMiSSF75399, SSF75399, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6V862_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6V862
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 2, 2021
Last modified: September 29, 2021
This is version 55 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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