UniProtKB - F6V6T6 (F6V6T6_HORSE)
Protein
Acetyl-CoA carboxylase kinase
Gene
PRKAA1
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP = [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H+ARBA annotationEC:2.7.11.31ARBA annotation
- [acetyl-CoA carboxylase]-L-serine + ATP = [acetyl-CoA carboxylase]-O-phospho-L-serine + ADP + H+ARBA annotationEC:2.7.11.27ARBA annotation
GO - Molecular functioni
- [acetyl-CoA carboxylase] kinase activity Source: UniProtKB-EC
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Source: UniProtKB-EC
- AMP-activated protein kinase activity Source: Ensembl
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: Ensembl
- histone serine kinase activity Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- CAMKK-AMPK signaling cascade Source: Ensembl
- cellular response to calcium ion Source: Ensembl
- cellular response to glucose starvation Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- cellular response to oxidative stress Source: Ensembl
- cellular response to prostaglandin E stimulus Source: Ensembl
- fatty acid oxidation Source: Ensembl
- glucose metabolic process Source: Ensembl
- intracellular signal transduction Source: GO_Central
- lipid biosynthetic process Source: Ensembl
- motor behavior Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of lipid catabolic process Source: Ensembl
- negative regulation of TOR signaling Source: Ensembl
- negative regulation of tubulin deacetylation Source: Ensembl
- neuron cellular homeostasis Source: Ensembl
- positive regulation of autophagy Source: Ensembl
- positive regulation of mitochondrial transcription Source: Ensembl
- positive regulation of peptidyl-lysine acetylation Source: Ensembl
- positive regulation of protein targeting to mitochondrion Source: Ensembl
- positive regulation of skeletal muscle tissue development Source: Ensembl
- protein phosphorylation Source: GO_Central
- regulation of circadian rhythm Source: Ensembl
- regulation of microtubule cytoskeleton organization Source: Ensembl
- regulation of peptidyl-serine phosphorylation Source: Ensembl
- regulation of stress granule assembly Source: Ensembl
- response to camptothecin Source: Ensembl
- response to gamma radiation Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to UV Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Biological rhythmsARBA annotation, Wnt signaling pathwayARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PRKAA1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:49523, PRKAA1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
- nucleus Source: GO_Central
Other locations
- axon Source: Ensembl
- cytoplasm Source: GO_Central
- dendrite Source: Ensembl
- neuronal cell body Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022617, Expressed in brainstem and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 353 | Protein kinaseInterPro annotationAdd BLAST | 253 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 77 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 559 – 610 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 65 | Pro-richSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000158865 |
HOGENOMi | CLU_000288_59_3_1 |
InParanoidi | F6V6T6 |
TreeFami | TF314032 |
Family and domain databases
CDDi | cd12199, AMPKA1_C, 1 hit |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039137, AMPKA1_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
F6V6T6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQGEEGGTGA PPSDPAPPRQ GERLRPTARG GDRAGGAGWR LGGAVPLPRP
60 70 80 90 100
HPLPRRPPAP GAALPAPSAP SRGAMRRLSS WRKMATAEKQ KHDGRVKIGH
110 120 130 140 150
YILGDTLGVG TFGKVKVGKH ELTGHKVAVK ILNRQKIRSL DVVGKIRREI
160 170 180 190 200
QNLKLFRHPH IIKLYQVIST PSDIFMVMEY VSGGELFDYI CKNGRLDEKE
210 220 230 240 250
SRRLFQQILS GVDYCHRHMV VHRDLKPENV LLDAHMNAKI ADFGLSNMMS
260 270 280 290 300
DGEFLRTSCG SPNYAAPEVI SGRLYAGPEV DIWSSGVILY ALLCGTLPFD
310 320 330 340 350
DDHVPTLFKK ICDGIFYTPQ YLNPSVISLL KHMLQVDPMK RATIKDIREH
360 370 380 390 400
EWFKQDLPKY LFPEDPSYSS TMIDDEALKE VCEKFECSEE EVLSCLYNRN
410 420 430 440 450
HQDPLAVAYH LIIDNRRIMN EAKDFYLATS PPDSFLDDHH LTRPHPERVP
460 470 480 490 500
FLVAETPRAR HTLDELNPQK SKHQGVRKAK WHLGIRSQSR PNDIMAEVCR
510 520 530 540 550
AIKQLDYEWK VVNPYYLRVR RKNPVTSTYS KMSLQLYQVD SRTYLLDFRS
560 570 580 590 600
IDDEITEAKS GTATPQRSGS VSNYRSCQRS DSDAEAQGKS SEASLTSSVT
610 620 630
SLDSSPVDLT PRPGSHTIEF FEMCANLIKI LAQ
Genome annotation databases
Ensembli | ENSECAT00000024304; ENSECAP00000020185; ENSECAG00000022617 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6V6T6 |
PRIDEi | F6V6T6 |
Genome annotation databases
Ensembli | ENSECAT00000024304; ENSECAP00000020185; ENSECAG00000022617 |
Organism-specific databases
VGNCi | VGNC:49523, PRKAA1 |
Phylogenomic databases
GeneTreei | ENSGT00940000158865 |
HOGENOMi | CLU_000288_59_3_1 |
InParanoidi | F6V6T6 |
TreeFami | TF314032 |
Gene expression databases
Bgeei | ENSECAG00000022617, Expressed in brainstem and 22 other tissues |
Family and domain databases
CDDi | cd12199, AMPKA1_C, 1 hit |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039137, AMPKA1_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6V6T6_HORSE | |
Accessioni | F6V6T6Primary (citable) accession number: F6V6T6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |