UniProtKB - F6UW24 (F6UW24_HORSE)
Protein
Ornithine carbamoyltransferase, mitochondrial
Gene
OTC
Organism
Equus caballus (Horse)
Status
Functioni
: urea cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-citrulline from L-ornithine and carbamoyl phosphate.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Ornithine carbamoyltransferase, mitochondrial (OTC), Ornithine carbamoyltransferase, mitochondrial (OTC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-citrulline from L-ornithine and carbamoyl phosphate, the pathway urea cycle and in Nitrogen metabolism.
GO - Molecular functioni
- amino acid binding Source: InterPro
- ornithine carbamoyltransferase activity Source: Ensembl
GO - Biological processi
- ammonium homeostasis Source: Ensembl
- citrulline biosynthetic process Source: Ensembl
- ornithine catabolic process Source: Ensembl
- urea cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseUniRule annotationARBA annotation |
Biological process | Urea cycleARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00158;UER00271 |
Names & Taxonomyi
Protein namesi | Recommended name: Ornithine carbamoyltransferase, mitochondrialARBA annotationAlternative name(s): Ornithine transcarbamylaseARBA annotation |
Gene namesi | Name:OTCImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:21078, OTC |
Subcellular locationi
Mitochondrion
- mitochondrion Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022838, Expressed in liver and 21 other tissues |
ExpressionAtlasi | F6UW24, baseline |
Interactioni
Subunit structurei
Homotrimer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 181 | OTCace_NInterPro annotationAdd BLAST | 142 | |
Domaini | 187 – 340 | OTCaceInterPro annotationAdd BLAST | 154 |
Sequence similaritiesi
Belongs to the aspartate/ornithine carbamoyltransferase superfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00510000047417 |
HOGENOMi | CLU_043846_3_0_1 |
InParanoidi | F6UW24 |
OrthoDBi | 1404554at2759 |
TreeFami | TF352580 |
Family and domain databases
Gene3Di | 3.40.50.1370, 2 hits |
InterProi | View protein in InterPro IPR006132, Asp/Orn_carbamoyltranf_P-bd IPR006130, Asp/Orn_carbamoylTrfase IPR036901, Asp/Orn_carbamoylTrfase_sf IPR006131, Asp_carbamoyltransf_Asp/Orn-bd IPR002292, Orn/put_carbamltrans |
Pfami | View protein in Pfam PF00185, OTCace, 1 hit PF02729, OTCace_N, 1 hit |
PRINTSi | PR00100, AOTCASE PR00102, OTCASE |
SUPFAMi | SSF53671, SSF53671, 1 hit |
TIGRFAMsi | TIGR00658, orni_carb_tr, 1 hit |
PROSITEi | View protein in PROSITE PS00097, CARBAMOYLTRANSFERASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6UW24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFNLRILLN NAALRNGPNF MVRNFRCGQP LQNKVQLKGR DLLTLKNFTG
60 70 80 90 100
EEIKYMLWLS ADLKFRIKQK GEYLPLLQGK SLGMIFEKRS TRTRLSTETG
110 120 130 140 150
FALLGGHPCF LTTQDIHLGV NESLTDTARV LSSMTDAVLA RVYKQSDLDV
160 170 180 190 200
LAKEASIPII NGLSDLYHPI QILADYLTLQ EHYGSLKGLT LSWIGDGNNI
210 220 230 240 250
LHSIMMSAAK VGMHLQVATP KGYEPDPNIT KLAEQYAKEN NTQLSLTNDP
260 270 280 290 300
LEAARGGNVL ITDTWISMGQ EEEKKKRLQA FQGYQVTMKT AKLAASDWTF
310 320 330 340 350
LHCLPRKPEE VDDEVFYSPR SLVFPEAENR KWTIMAIMVS LLTDYSPQLQ
KPKF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2LH62 | A0A3Q2LH62_HORSE | Ornithine carbamoyltransferase, mit... | OTC | 339 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024582; ENSECAP00000020428; ENSECAG00000022838 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6UW24 |
Genome annotation databases
Ensembli | ENSECAT00000024582; ENSECAP00000020428; ENSECAG00000022838 |
Organism-specific databases
VGNCi | VGNC:21078, OTC |
Phylogenomic databases
GeneTreei | ENSGT00510000047417 |
HOGENOMi | CLU_043846_3_0_1 |
InParanoidi | F6UW24 |
OrthoDBi | 1404554at2759 |
TreeFami | TF352580 |
Enzyme and pathway databases
UniPathwayi | UPA00158;UER00271 |
Gene expression databases
Bgeei | ENSECAG00000022838, Expressed in liver and 21 other tissues |
ExpressionAtlasi | F6UW24, baseline |
Family and domain databases
Gene3Di | 3.40.50.1370, 2 hits |
InterProi | View protein in InterPro IPR006132, Asp/Orn_carbamoyltranf_P-bd IPR006130, Asp/Orn_carbamoylTrfase IPR036901, Asp/Orn_carbamoylTrfase_sf IPR006131, Asp_carbamoyltransf_Asp/Orn-bd IPR002292, Orn/put_carbamltrans |
Pfami | View protein in Pfam PF00185, OTCace, 1 hit PF02729, OTCace_N, 1 hit |
PRINTSi | PR00100, AOTCASE PR00102, OTCASE |
SUPFAMi | SSF53671, SSF53671, 1 hit |
TIGRFAMsi | TIGR00658, orni_carb_tr, 1 hit |
PROSITEi | View protein in PROSITE PS00097, CARBAMOYLTRANSFERASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6UW24_HORSE | |
Accessioni | F6UW24Primary (citable) accession number: F6UW24 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |