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Entry version 69 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein

HECT-type E3 ubiquitin transferase

Gene

HUWE1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4348Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairARBA annotation, Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HUWE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:18916, HUWE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6UR14

PRoteomics IDEntifications database

More...
PRIDEi
F6UR14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1337 – 1376UBAInterPro annotationAdd BLAST40
Domaini1624 – 1701WWEInterPro annotationAdd BLAST78
Domaini4045 – 4381HECTInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni727 – 779DisorderedSequence analysisAdd BLAST53
Regioni999 – 1059DisorderedSequence analysisAdd BLAST61
Regioni1312 – 1341DisorderedSequence analysisAdd BLAST30
Regioni1417 – 1436DisorderedSequence analysisAdd BLAST20
Regioni2039 – 2086DisorderedSequence analysisAdd BLAST48
Regioni2283 – 2363DisorderedSequence analysisAdd BLAST81
Regioni2377 – 2500DisorderedSequence analysisAdd BLAST124
Regioni2715 – 2991DisorderedSequence analysisAdd BLAST277
Regioni3057 – 3080DisorderedSequence analysisAdd BLAST24
Regioni3262 – 3288DisorderedSequence analysisAdd BLAST27
Regioni3375 – 3402DisorderedSequence analysisAdd BLAST28
Regioni3426 – 3446DisorderedSequence analysisAdd BLAST21
Regioni3492 – 3531DisorderedSequence analysisAdd BLAST40
Regioni3560 – 3588DisorderedSequence analysisAdd BLAST29
Regioni3759 – 3780DisorderedSequence analysisAdd BLAST22
Regioni3801 – 3855DisorderedSequence analysisAdd BLAST55
Regioni3901 – 3941DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3111 – 3131Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi758 – 777PolarSequence analysisAdd BLAST20
Compositional biasi1008 – 1025PolarSequence analysisAdd BLAST18
Compositional biasi1312 – 1331PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2039 – 2056PolarSequence analysisAdd BLAST18
Compositional biasi2057 – 2081PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2283 – 2316PolarSequence analysisAdd BLAST34
Compositional biasi2405 – 2423PolarSequence analysisAdd BLAST19
Compositional biasi2427 – 2492AcidicSequence analysisAdd BLAST66
Compositional biasi2715 – 2739PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2740 – 2789PolarSequence analysisAdd BLAST50
Compositional biasi2790 – 2804Pro-richSequence analysisAdd BLAST15
Compositional biasi2836 – 2912PolarSequence analysisAdd BLAST77
Compositional biasi2939 – 2955PolarSequence analysisAdd BLAST17
Compositional biasi3062 – 3080PolarSequence analysisAdd BLAST19
Compositional biasi3265 – 3281PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3560 – 3577PolarSequence analysisAdd BLAST18
Compositional biasi3820 – 3836PolarSequence analysisAdd BLAST17
Compositional biasi3901 – 3918PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156319

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000058_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6UR14

TreeFam database of animal gene trees

More...
TreeFami
TF323417

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012, DUF908, 2 hits
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F6UR14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAEKY PPSATTLHFE FYADPGAEVK IEKRTTSNTL
210 220 230 240 250
HYIHIEQLDK ISESPSEIME SLTKMYSIPK DKQMLLFTHI RLAHGFSNHR
260 270 280 290 300
KRLQAVQARL HAISILVYSN ALQESANSIL YNGLIEELVD VLQITDKQLM
310 320 330 340 350
EIKAASLRTL TSIVHLERTP KLSSIIDCTG TASYHGFLPV LVRNCIQAMI
360 370 380 390 400
DPSMDPYPHQ FATALFSFLY HLASYDAGGE ALVSCGMMEA LLKVIKFLGD
410 420 430 440 450
EQDQITFVTR AVRVVDLITN LDMAAFQSHS GLSIFIYRLE HEVDLCRKEC
460 470 480 490 500
PFVIKPKIQR PSTTQEGEEM ETDMDVADVT MESSSGLSIS MEHRLDVELR
510 520 530 540 550
AGPSSSTSIS SGPGPRPGVQ CIPQRAALLK SMLNFLKKAI QDPAFSDGIR
560 570 580 590 600
HVMDGSLPTS LKHIISNAEY YGPSLFLLAT EVVTVFVFQE PSLLSSLQDN
610 620 630 640 650
GLTDVMLHAL LIKDVPATRE VLGSLPNVFS ALCLNARGLQ SFVQCQPFER
660 670 680 690 700
LFKVLLSPDY LPAMRRRRSS DPLGDTASNL GSAVDELMRH QPTLKTDATT
710 720 730 740 750
AIIKLLEEIC NLGRDPKYIC QKPSIQKADG TATAPPPRSN HAAEEASSED
760 770 780 790 800
EEEEEVQAMQ SFNSAQQNET EPNQQVVGTE ERIPIPLMDY ILNVMKFVES
810 820 830 840 850
ILSNNTTDDH CQEFVNQKGL LPLVTILGLP NLPIDFPTSA ACQAVAGVCK
860 870 880 890 900
SILTLSHEPK VLQEGLLQLD SILSSLEPLH RPIESPGGSV LLRELACAGN
910 920 930 940 950
VADATLSAQA TPLLHALTAA HAYIMMFVHT CRVGQSEIRS ISVNQWGSQL
960 970 980 990 1000
GLSVLSKLSQ LYCSLVWEST VLLSLCTPNS LPSGCEFGQA DMQKLVPKDE
1010 1020 1030 1040 1050
KAGTTQGGKR SDGEQDGTAG SMDASTQGLL EGIGLDGDTL APMETDEPTT
1060 1070 1080 1090 1100
SDSKGKSKIT PAMAARIKQI KPLLSASSRL GRALAELFGL LVKLCVGSPV
1110 1120 1130 1140 1150
RQRRSHHAAS TTTAPTPAAR STASALTKLL TKGLSWQPPP YTPTPRFRLT
1160 1170 1180 1190 1200
FFICSVGFTS PMLFDERKYP YHLMLQKFLC SGGHNALFET FNWALSMGGK
1210 1220 1230 1240 1250
VPVAEGLEHS ELPDGTGEFL DAWLMLVEKM VNPTTVLESP HSLPAKLPGG
1260 1270 1280 1290 1300
VQNFPQFSAL RFLVVTQKAA FTCIKNLWNR KPLKVYGGRM AESMLAILCH
1310 1320 1330 1340 1350
ILRGEPVIRE RLSKEKEGSR GEEDTGQEEG GSRREPQVNQ QQLQQLMDMG
1360 1370 1380 1390 1400
FTREHAMEAL LNTSTMEQAT EYLLTHPPPI MGGVVRDLSM SEEDQMMRAI
1410 1420 1430 1440 1450
AMSLGQDIPM DQRAESPEEV ACRKEEEERK AREKQEEEEA KCLEKFQDAD
1460 1470 1480 1490 1500
PLEQDELHTF TDTMLPGCFH LLDELPDTVY RVCDLIMTAI KRNGADYRDM
1510 1520 1530 1540 1550
ILKQVVNQVW EAADVLIKAA LPLTTSDTKT VSEWISQMAT LPQASNLATR
1560 1570 1580 1590 1600
ILLLTLLFEE LKLPCAWVVE SSGILNVLIK LLEVVQPCLQ AAKEQKEVQT
1610 1620 1630 1640 1650
PKWITPVLLL IDFYEKTAIS SKRRAQMTKY LQSNNNNWRW FDDRSGRWCS
1660 1670 1680 1690 1700
YSASNNSTID SAWKSGETSV RFTAGRRRYT VQFTTMVQVN EETGNRRPVM
1710 1720 1730 1740 1750
LTLLRVPRLN KNSKNSNGQE LEKTLEESKE MDIKRKENKA NDTPLALEST
1760 1770 1780 1790 1800
NIEKETSLEE TKIGEILIQG LTEDMVTVLI RACVSMLGVP VDPDTLHATL
1810 1820 1830 1840 1850
RLCLRLTRDH KYAMMFAELK STRMILNLTQ SSGFNGFTPL VTLLLRHIIE
1860 1870 1880 1890 1900
DPCTLRHTME KVVRSAATSG AGSTTSGVVS GSLGSREINY ILRVLGPAAC
1910 1920 1930 1940 1950
RNPDIFTEVA NCCIRIALPA PRGSGTASDD EFENLRIKGP NAVQLVKTTP
1960 1970 1980 1990 2000
LKPSPLPVIP DTIKEVIYDM LNALAAYHAP EEADKSDPKP GGMTQEVGQL
2010 2020 2030 2040 2050
LQDMGDDVYQ QYRSLTRQSS DFDTQSGFSL NSQVFAADGT STETSTSGAT
2060 2070 2080 2090 2100
QGEASTPEES RDGKKDKEGD RASEEGKQKG KGSKPLMPTS TILRLLAELV
2110 2120 2130 2140 2150
RSYVGIATLI ANYSYTVGQS ELIKEDCSVL AFVLDHLLPH TQNAEDKDTP
2160 2170 2180 2190 2200
ALARLFLASL AAAGSGTDAQ VALVNEVKAA LGRALAMAES TEKHARLQAV
2210 2220 2230 2240 2250
MCIISTIMES CPSTSSFYSS ATAKTQHNGM NNIIRLFLKK GLVNDLARVP
2260 2270 2280 2290 2300
HSLDLSSPNM ANTVNAALKP LETLSRIVNQ PSSLFGSKSA SSKSKSEQDA
2310 2320 2330 2340 2350
QGASQDSNSN QQDPGEPGEA EVQEEDHDVT QTEVADGDIM DGEAETDSVV
2360 2370 2380 2390 2400
IAGQPEVLSS QEMQVENELE DLIDELLERD GGSGNSTIIV SRSGEDESQE
2410 2420 2430 2440 2450
DVLMDEAPSN LSQASTLQAN REDSMNILDP EDEEEHTQEE DSSGSNEDED
2460 2470 2480 2490 2500
DSQDEEEEEE EDEEDDQEDD EGEEGDEDDD DDGSEMELDE DYPDMNASPL
2510 2520 2530 2540 2550
VRFERFDRED DLIIEFDNMF SSATDIPPSP GNIPTTHPLM VRHADHSSLT
2560 2570 2580 2590 2600
LGSGSSTTRL TQGIGRSQRT LRQLTANTGH TIHVHYPGNR QPNPPLILQR
2610 2620 2630 2640 2650
LLGPSAAADI LQLSSSLPLQ SRGRARLLVG NDDVHIIARS DDELLDDFFH
2660 2670 2680 2690 2700
DQSTATSQAG TLSSIPTALT RWTEECKVLD AESMHDCVSV VKVPIVNHLE
2710 2720 2730 2740 2750
FLRDEELEER REKRRKQLAE EETKITDKGK EDKENRDQSA QCTASKTNDS
2760 2770 2780 2790 2800
TEQNLSDGTP MPDSYPTTPS STDAATSEPK ETLVTLQPSQ QPPTLPPPPA
2810 2820 2830 2840 2850
LGEIPQELQS PAGERGSSTQ LLMPVEPEEL GPTRPSGEAE TTQMELSPAP
2860 2870 2880 2890 2900
TITSLSPERA EDSDALTAVS SQLEGSPMDT SSLASCTLEE AVGDTSAAGS
2910 2920 2930 2940 2950
SEQPTAGSST PGDAPPVVTE LQGGGDESGE PAQPPEDSSP PASSESSSTR
2960 2970 2980 2990 3000
DSAVAISGAD SRGILEEPLP STSSEEEDPL AGISLPEGVD PSFLAALPDD
3010 3020 3030 3040 3050
IRREVLQNQL GIRPPTRTAP STNSSAPAVV GNPGVTEVSP EFLAALPPAI
3060 3070 3080 3090 3100
QEEVLAQQRA EQQRRELAQN ASSDTPMDPV TFIQTLPSDL RRSVLEDMED
3110 3120 3130 3140 3150
SVLAVMPPDI AAEAQALRRE QEARQRQLMH ERLFGHSSTS ALSAILRSPA
3160 3170 3180 3190 3200
FTSRLSGNRG VQYTRLAVQR GGTFQMGGSS SHNRPSGSNV DTLLRLRGRL
3210 3220 3230 3240 3250
LLDHEALSCL LVLLFVDEPK LNTSRLHRVL RNLCYHAQTR HWVIRSLLSI
3260 3270 3280 3290 3300
LQRSSESELC IETPKLSSSE EKGKKSSKSC GSSSHENRPL DLLHKMESKS
3310 3320 3330 3340 3350
SNQLSWLSVS MDAALGCRTN IFQIQRSGGR KHTEKHASSG STVHIHPQAA
3360 3370 3380 3390 3400
PVVCRHVLDT LIQLAKVFPS HFTQQRTKET NCESDRERGS KQTCSPCSSQ
3410 3420 3430 3440 3450
PNSSGICTDF WDLLVKLDNM NVSRKGKNSV KSVPVSASGE GETSPYSLEA
3460 3470 3480 3490 3500
SPLGQLMNML SHPVIRRSSL LTEKLLRLLS LISIALPENK VSEAQTNSGS
3510 3520 3530 3540 3550
SASSTTVTTS TTSTTTTTAA SSTPTPATAT TPVTSAPALV AATAISTIAV
3560 3570 3580 3590 3600
AASTTVTTPT TATTTVSTCT TTKASKSPAK VGDGGSSSAD FKMVSSGLTE
3610 3620 3630 3640 3650
NQLQLSVEVL TSHSCSEEGL EDAANVLLQL SRGDSGTRDT VLKLLLNGAR
3660 3670 3680 3690 3700
HLGYTLCKQI GTLLAELREY NLEQQRRAQC ETLSPDGLPE EQPQTTKLKG
3710 3720 3730 3740 3750
KMQSRFDMAE NVVIVASQKR PLGGRELQLP SMSMLTSKTS TQKFFLRVLQ
3760 3770 3780 3790 3800
VIIQLRDDTR RANKKAKQTG RLGSSGLGSA SSIQAAVRQL EAEADAIIQM
3810 3820 3830 3840 3850
SESSQSEASV RREESPMDVD QPSPSAQDTQ SIGSDGALQG EKEKEERPPE
3860 3870 3880 3890 3900
LPLLSEQLSL DELWDMLGEC LKELEESHDQ HAVLVLQPAV EAFFLVHATE
3910 3920 3930 3940 3950
RESKPPVRDT RESQLAHIKD EPPPLSPAPL TPATPSSLDP FFSREPSSMH
3960 3970 3980 3990 4000
ISSSLPPDTQ KFLRFAETHR TVLNQILRQS TTHLADGPFA VLVDYIRVLD
4010 4020 4030 4040 4050
FDVKRKYFRQ ELERLDEGLR KEDMAVHVRR DHVFEDSYRE LHRKSPEEMK
4060 4070 4080 4090 4100
NRLYIVFEGE EGQDAGGLLR EWYMIISREM FNPMYALFRT SPGDRVTYTI
4110 4120 4130 4140 4150
NPSSHCNPNH LSYFKFVGRI VAKAVYDNRL LECYFTRSFY KHILGKSVRY
4160 4170 4180 4190 4200
TDMESEDYHF YQGLVYLLEN DVSTLGYDLT FSTEVQEFGV CEVRDLKPNG
4210 4220 4230 4240 4250
ANILVTEENK KEYVHLVCQM RMTGAIRKQL AAFLEGFYEI IPKRLISIFT
4260 4270 4280 4290 4300
EQELELLISG LPTIDIDDLK SNTEYHKYQS NSIQIQWFWR ALRSFDQADR
4310 4320 4330 4340 4350
AKFLQFVTGT SKVPLQGFAA LEGMNGIQKF QIHRDDRSTD RLPSAHTCFN
4360 4370 4380
QLDLPAYESF EKLRHMLLLA IQECSEGFGL A
Length:4,381
Mass (Da):482,446
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2A627B2BC5D185C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HWQ7A0A3Q2HWQ7_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,417Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZJZ7F6ZJZ7_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,343Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H4T8A0A3Q2H4T8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HF72A0A3Q2HF72_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L3C6A0A3Q2L3C6_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PKP8A0A5F5PKP8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PN32A0A5F5PN32_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSECAT00000024329; ENSECAP00000020205; ENSECAG00000021385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6UR14
PRIDEiF6UR14

Genome annotation databases

EnsembliENSECAT00000024329; ENSECAP00000020205; ENSECAG00000021385

Organism-specific databases

VGNCiVGNC:18916, HUWE1

Phylogenomic databases

GeneTreeiENSGT00940000156319
HOGENOMiCLU_000058_0_0_1
InParanoidiF6UR14
TreeFamiTF323417

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF06012, DUF908, 2 hits
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6UR14_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6UR14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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