UniProtKB - F6UP52 (F6UP52_HORSE)
Protein
Submitted name:
Myosin heavy chain 8
Gene
MYH8
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATPase activity Source: Ensembl
- ATP binding Source: UniProtKB-UniRule
- microfilament motor activity Source: Ensembl
GO - Biological processi
- ATP metabolic process Source: Ensembl
- muscle filament sliding Source: Ensembl
- skeletal muscle contraction Source: Ensembl
Keywordsi
Molecular function | Actin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Myosin heavy chain 8Imported |
Gene namesi | Name:MYH8Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56451, MYH8 |
Subcellular locationi
Cytoskeleton
- myosin complex Source: UniProtKB-KW
Other locations
- cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSECAG00000019706, Expressed in gluteus medius and 7 other tissues |
ExpressionAtlasi | F6UP52, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 84 | Myosin N-terminal SH3-likeInterPro annotationAdd BLAST | 50 | |
Domaini | 88 – 781 | Myosin motorInterPro annotationAdd BLAST | 694 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1124 – 1173 | DisorderedSequence analysisAdd BLAST | 50 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1196 – 1293 | Sequence analysisAdd BLAST | 98 | |
Coiled coili | 1301 – 1335 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1343 – 1377 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1379 – 1441 | Sequence analysisAdd BLAST | 63 | |
Coiled coili | 1456 – 1592 | Sequence analysisAdd BLAST | 137 | |
Coiled coili | 1611 – 1645 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1660 – 1715 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 1723 – 1806 | Sequence analysisAdd BLAST | 84 | |
Coiled coili | 1808 – 1842 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1864 – 1926 | Sequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1124 – 1154 | PolyampholyteSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161785 |
HOGENOMi | CLU_000192_8_0_1 |
InParanoidi | F6UP52 |
TreeFami | TF314375 |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6UP52-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSASSDAEMA VFGEAAPYLR KSEKERIEAQ NKPFDAKTSV FVTEPKESYV
60 70 80 90 100
KSTIQSKEGG RITVKTEGGA TLTVREDQVF PMNPPKYDKI EDMAMMTHLH
110 120 130 140 150
EPGVLYNLKE RYAAWMIYTY SGLFCVTVNP YKWLPVYNPE VVAAYRGKKR
160 170 180 190 200
QEAPPHIFSI SDNAYQFMLT DRENQSILIT GESGAGKTVN TKRVIQYFAT
210 220 230 240 250
IAVTGEKKKE EPGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFISQGE ITVPSIDDQE ELMATDSAID ILGFTPEEKV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP LGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYDQHL GKSANFQKPK VVKGKAEAHF SLIHYAGTVD YNITGWLDKN
610 620 630 640 650
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADSSAKKGA KKKGSSFQTV
660 670 680 690 700
SALFRENLNK LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG
710 720 730 740 750
VLEGIRICRK GFPSRILYGD FKQRYKLLNA SAIPEGQFID SKKASEKLLA
760 770 780 790 800
SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR DEKLAQIITR TQAVCRGFLM
810 820 830 840 850
RVEYQKMLQR REALFCIQYN VRAFMNVKHW PWMKLFFKIK PLLKSAETEK
860 870 880 890 900
EMATMKEEFQ KTKDELAKSE AKRKELEEKM VTLLKEKNDL QLQVQSEADA
910 920 930 940 950
LADAEERCEQ LIKNKIQLEA KIKEATERAE DEEEINAELT AKKRKLEDEC
960 970 980 990 1000
SELKKDIDDL ELTLAKVEKE KHATENKVKN LTEEMAGLDE TIAKLTKEKK
1010 1020 1030 1040 1050
ALQEAHQQTL DDLQTEEDKV STLTKAKTKL EQQVDDLEGS LEQEKKLRMD
1060 1070 1080 1090 1100
LERAKRKLEG DLKLAQESTM DIENDKQQLD EKLKKKEFEI SNLLSKIEDE
1110 1120 1130 1140 1150
QAVEIQLQKK IKELQARIEE LEEEIEAERA SRAKAEKQRS DLSRELEEIS
1160 1170 1180 1190 1200
ERLEEAGGAT SAQIEMNKKR ETEFQKMRRD LEEATLQHEA TAAALRKKHA
1210 1220 1230 1240 1250
DSVAELGEQI DNLQRVKQKL EKEKSEMKME IDDLSSNAEA ISKAKANLEK
1260 1270 1280 1290 1300
MCRTLEDQLS ELKTKEEEQQ RLINDLTAQR ARLQTEAGEY SRQLDEKDAL
1310 1320 1330 1340 1350
VSQLSRSKQA FTQQIEELKR QLEEETKAKN ALAHALQSSR HDCDLLREQY
1360 1370 1380 1390 1400
EEEQEGKAEL QRALSKANSE VAQWRTKYET DAIQRTEELE EAKKKLAQRL
1410 1420 1430 1440 1450
QEAEEHVEAV NAKCASLEKT KQRLQNEVED LMLDVERSNA ACAALDKKQR
1460 1470 1480 1490 1500
NFDKVLSEWK QKYEETQAEL EASQKESRSL STELFKVKNA YEESLDQLET
1510 1520 1530 1540 1550
LKRENKNLQQ EISDLTEQIA EGGKQIHELE KIKKQVEQEK CDIQAALEEA
1560 1570 1580 1590 1600
EASLEHEEGK ILRIQLELNQ VKSEVDRKIA EKDEEIDQLK RNHIRVVETM
1610 1620 1630 1640 1650
QSTLDAEIRS RNDALRVKKK MEGDLNEMEI QLNHANRLAA ETLRNYRNTQ
1660 1670 1680 1690 1700
GILKDTQLHL DDALRGQEDL KEQLAMVERR ANLLQAEIEE LRATLEQTER
1710 1720 1730 1740 1750
SRKIAEQELL DASERVQLLH TQNTSLINTK KKLENDVSQL QSEVEEVIQE
1760 1770 1780 1790 1800
SRNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNME QTVKDLQHRL
1810 1820 1830 1840 1850
DEAEQLALKG GKKQIQKLEA RVRELEGEVE SEQKRNAEAV KGLRKHERRV
1860 1870 1880 1890 1900
KELTYQTEED RKNVLRLQDL VDKLQAKVKS YKRQAEEAEE QSNANLAKFR
1910 1920 1930
KLQHELEEAE ERADIAESQV NKLRVKSREV HTKLSAE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HYK9 | A0A3Q2HYK9_HORSE | Myosin heavy chain 8 | MYH8 | 1,928 | Annotation score: |
Sequence databases
RefSeqi | XP_001504901.1, XM_001504851.4 |
Genome annotation databases
Ensembli | ENSECAT00000024411; ENSECAP00000020277; ENSECAG00000019706 |
GeneIDi | 100062893 |
KEGGi | ecb:100062893 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001504901.1, XM_001504851.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6UP52 |
Genome annotation databases
Ensembli | ENSECAT00000024411; ENSECAP00000020277; ENSECAG00000019706 |
GeneIDi | 100062893 |
KEGGi | ecb:100062893 |
Organism-specific databases
CTDi | 4626 |
VGNCi | VGNC:56451, MYH8 |
Phylogenomic databases
GeneTreei | ENSGT00940000161785 |
HOGENOMi | CLU_000192_8_0_1 |
InParanoidi | F6UP52 |
TreeFami | TF314375 |
Gene expression databases
Bgeei | ENSECAG00000019706, Expressed in gluteus medius and 7 other tissues |
ExpressionAtlasi | F6UP52, baseline |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6UP52_HORSE | |
Accessioni | F6UP52Primary (citable) accession number: F6UP52 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |