UniProtKB - F6UP14 (F6UP14_HORSE)
Protein
Submitted name:
Procollagen C-endopeptidase enhancer 2
Gene
PCOLCE2
Organism
Equus caballus (Horse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- collagen binding Source: Ensembl
- heparin binding Source: Ensembl
- peptidase activator activity Source: Ensembl
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Procollagen C-endopeptidase enhancer 2Imported |
Gene namesi | Name:PCOLCE2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56838, PCOLCE2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5018729115 | 23 – 414 | Sequence analysisAdd BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 153 ↔ 180 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PaxDbi | F6UP14 |
PRIDEi | F6UP14 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020485, Expressed in articular cartilage of joint and 19 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 143 | CUBInterPro annotationAdd BLAST | 112 | |
Domaini | 153 – 267 | CUBInterPro annotationAdd BLAST | 115 | |
Domaini | 296 – 414 | NTRInterPro annotationAdd BLAST | 119 |
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157649 |
HOGENOMi | CLU_034096_0_0_1 |
InParanoidi | F6UP14 |
OMAi | TEVCAQS |
TreeFami | TF316506 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd03576, NTR_PCOLCE, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035814, NTR_PCOLCE IPR035914, Sperma_CUB_dom_sf IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00042, CUB, 2 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS50189, NTR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6UP14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGAGAWAPL CLLLAAAQPS RQQPPERPVF ACGGILTGES GFIGSEGFPG
60 70 80 90 100
VYPPNSKCTW KITVPEGKVV VLNFRFIDLE SDNLCRYDFV DVYNGHANGQ
110 120 130 140 150
RIGRFCGTFR PGALVSSGNK MMVQMISDAN TAGNGFMAMF SAAEPNERGD
160 170 180 190 200
QYCGGLLERP SGSFTTPNWP DRDYPAGVTC VWHIVAPKNQ LVELKFEKFD
210 220 230 240 250
VERDNYCRYD YVAVFNGGEA NDAQRIGKYC GDSPPAPIVS ERNELLIQFL
260 270 280 290 300
SDLSLTADGF IAHYQFRPKK LPATTVPPVT TTFPVTTDLK PTVALCQQKC
310 320 330 340 350
RRTGTLESNY CSSNFVLAGT VITTITRGGS LHATVSIINI YKEGNLAIQQ
360 370 380 390 400
AGKNMSAKVV VVCKQCPLLR RGLNYIIMGQ VGEDGRGKIM PNSFIMMFKT
410
KNQKLLNALE NKQC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PKQ8 | A0A5F5PKQ8_HORSE | Procollagen C-endopeptidase enhance... | PCOLCE2 | 386 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000021960; ENSECAP00000018126; ENSECAG00000020485 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | F6UP14 |
ModBasei | Search... |
Proteomic databases
PaxDbi | F6UP14 |
PRIDEi | F6UP14 |
Genome annotation databases
Ensembli | ENSECAT00000021960; ENSECAP00000018126; ENSECAG00000020485 |
Organism-specific databases
VGNCi | VGNC:56838, PCOLCE2 |
Phylogenomic databases
GeneTreei | ENSGT00940000157649 |
HOGENOMi | CLU_034096_0_0_1 |
InParanoidi | F6UP14 |
OMAi | TEVCAQS |
TreeFami | TF316506 |
Gene expression databases
Bgeei | ENSECAG00000020485, Expressed in articular cartilage of joint and 19 other tissues |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd03576, NTR_PCOLCE, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035814, NTR_PCOLCE IPR035914, Sperma_CUB_dom_sf IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00042, CUB, 2 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6UP14_HORSE | |
Accessioni | F6UP14Primary (citable) accession number: F6UP14 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | April 7, 2021 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |